20 Result(s)
within
**-Sup Shin
Neurosciences
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Article
Altruism and social rewards
Scheggia et al.1 have established a behavioral paradigm to explore preferences for ‘altruistic’ or ‘selfish’ choice behavior in mice. The results suggest that altruistic behavior develops through reinforcement le...
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Neurocognitive profile in children with arachnoid cysts before and after surgical intervention
Treatment indications for arachnoid cysts are not clear. Some surgeons take improvement in neurocognitive function into account as a surgical indication for arachnoid cysts. However, only a few studies have ev...
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Open Access26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3
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Open AccessThe thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture
The transition from wakefulness to a nonrapid eye movement (NREM) sleep state at the onset of sleep involves a transition from low-voltage, high-frequency irregular electroencephalography (EEG) waveforms to la...
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Open Access25th Annual Computational Neuroscience Meeting: CNS-2016
A1 Functional advantages of cell-type heterogeneity in neural circuits
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T-type Ca2+ channels facilitate NO-formation, vasodilatation and NO-mediated modulation of blood pressure
Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxid...
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Open AccessThe role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
We aimed to determine whether early parenting is associated with externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder (ADHD) and whether such an association is aff...
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No association of the norepinephrine transporter gene (SLC6A2) and cognitive and behavioural phenotypes of patients with autism spectrum disorder
We examined the association between the norepinephrine transporter (SLC6A2) gene and autism spectrum disorder (ASD) in a Korean population. In addition, we investigated which phenotypes of ASD are best attribute...
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Open AccessExtrasynaptic GABAA receptors in mediodorsal thalamic nucleus modulate fear extinction learning
The gamma-amino-butyric acid (GABA) system is a critical mediator of fear extinction process. GABA can induce “phasic” or “tonic” inhibition in neurons through synaptic or extrasynaptic GABAA receptors, respectiv...
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T-type Ca2+ channels in absence epilepsy
Absence epilepsy accompanies the paroxysmal oscillations in the thalamocortical circuit referred as spike and wave discharges (SWDs). Low-threshold burst firing mediated by T-type Ca2+ channels highly expressed i...
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Open AccessAssociation between the GRM7 rs3792452 polymorphism and attention deficit hyperacitiveity disorder in a Korean sample
The purpose of this study was to investigate the association between the ionotropic and glutamate receptors, N-methyl D-asparate 2A (GRIN2A) and 2B (GRIN2B), and the metabotropic glutamate receptor mGluR7 (GRM...
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Open AccessPossible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder
Dysregulation of noradrenergic system may play important roles in pathophysiology of attention-deficit/hyperactivity disorder (ADHD). We examined the relationship between polymorphisms in the norepinephrine tr...
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Bidirectional modulation of fear extinction by mediodorsal thalamic firing in mice
The mediodorsal thalamus links the medial prefrontal cortex and the amygdala in associative learning process in primates. Using mouse models, this study finds that the dual firing modes of mediodorsal thalamus...
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GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice
ADHD is characterized by hyperactivity and deficits in learning and memory. Now, Eunjoon Kim and colleagues report that a polymorphism in the gene that encodes the adaptor protein GIT1 is linked to ADHD in hum...
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Open AccessPossible association of norepinephrine transporter -3081(A/T) polymorphism with methylphenidate response in attention deficit hyperactivity disorder
Attention-deficit/hyperactivity disorder (ADHD) is a heritable disorder characterized by symptoms of inattention and/or hyperactivity/impulsivity. Methylphenidate (MPH) has been shown to block the norepinephri...
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Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC
Primates can develop a conditioned fear response by witnessing other primates being subjected to adverse stimuli. Jeon et al. report that mice are capable of this form of observational fear conditioning and that ...
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Null Mutation of α1D Ca2+ Channel Gene Results in Deafness but No Vestibular Defect in Mice
Multiple Ca2+ channels confer diverse functions to hair cells of the auditory and vestibular organs in the mammalian inner ear. We used gene-targeting technology to generate α1D Ca2+ channel-deficient mice to det...
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Translation of clock rhythmicity into neural firing in suprachiasmatic nucleus requires mGluR–PLCβ4 signaling
Phospholipase C β4 (PLCβ4) is expressed in the suprachiasmatic nucleus (SCN), as well as in tissues in the circadian entrainment pathway, including the retina and the lateral geniculate nucleus in the mouse1,2. U...
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Regional cerebral perfusion abnormalities in attention deficit/hyperactivity disorder
Objective: A voxel based investigation of cerebral blood flow was conducted to identify brain function differences in the resting state between children with Attention Deficit Hyperactivity Disorder (ADHD) and n...
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PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex
During development of the cerebral cortex, the invasion of thalamic axons and subsequent differentiation of cortical neurons are tightly coordinated. Here we provide evidence that glutamate neurotransmission t...
