Enhancing Holistic Well-Being of Children and Youth
Insights from Singapore for Research, Policy and Practice in Education
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Open AccessHourly step recommendations to achieve daily goals for working and older adults
The widespread use of physical activity trackers enables the collection of high-resolution health data, such as hourly step counts, to evaluate health promotion programmes. We aim to investigate how participan...
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Mechanistic study on vasodilatory and antihypertensive effects of hesperetin: ex vivo and in vivo approaches
Hesperetin is one of the prominent flavonoids found in citrus fruit. Several research studies have reported that hesperetin can promote vasodilation in vascular tissue by increasing the level of nitric oxide a...
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Open AccessUpdate to: Assessing the efficacy of male Wolbachia-infected mosquito deployments to reduce dengue incidence in Singapore
This trial is a parallel, two-arm, non-blinded cluster randomised controlled trial that is under way in Singapore, with the aim of measuring the efficacy of male Wolbachia-infected Aedes aegypti deployments in re...
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Surgical management of tibial eminence avulsion fractures: a systematic review and meta-analysis
The ideal surgical management for tibial eminence avulsion fractures remains controversial with varying approach, methods of fixation and post-operative regimes reported throughout literature. The current syst...
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Open AccessPrecise mode control of laser-written waveguides for broadband, low-dispersion 3D integrated optics
Three-dimensional (3D) glass chips are promising waveguide platforms for building hybrid 3D photonic circuits due to their 3D topological capabilities, large transparent windows, and low coupling dispersion. A...
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A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells
The manufacturing of autologous chimaeric antigen receptor (CAR) T cells largely relies either on fed-batch and manual processes that often lack environmental monitoring and control or on bioreactors that cann...
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Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure
Successful approaches for eradication or cure of HIV-1 infection are likely to include immunological mechanisms, but remarkably little is known about how human immune responses can recognize and interact with ...
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The effects of acute social ostracism on subsequent snacking behavior and future body mass index in children
Ostracism may lead to increased food intake, yet it is unclear whether greater reactivity to ostracism contributes to higher body mass index (BMI). We investigated whether children who exhibited greater stress...
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Targeting TtVgR via siRNA Knockdown Elicits Ovarian Cell Death in the Tri-spine Horseshoe Crab
The vitellogenin present in the bloodstream undergoes internalization into develo** oocytes through the vitellogenin receptor (VgR), a process mediated by receptor-mediated endocytosis. VgR plays a crucial role...
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Open AccessChallenges of care coordination for complex patients among family medicine residents in a community ambulatory clinic: a qualitative study
Care coordination has been identified as one of five focuses of HealthierSG. Family medicine residents are expected to collaborate with other healthcare professionals for complex patients by the end of residen...
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The roles of social support, family support, co** strategies, and financial safety in posttraumatic growth among COVID-19 survivors in Kerala
The infection with coronavirus disease 2019 (COVID-19) and the pandemic have had a profound impact on people’s physical health and mental well-being. While studies have shown that frontline healthcare workers ...
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Actively tunable laser action in GeSn nanomechanical oscillators
Mechanical forces induced by high-speed oscillations provide an elegant way to dynamically alter the fundamental properties of materials such as refractive index, absorption coefficient and gain dynamics. Alth...
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Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c Mice
The protective efficacies of current licensed vaccines against COVID-19 have significantly reduced as a result of SARS-CoV-2 variants of concern (VOCs) which carried multiple mutations in the Spike (S) protein...
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Open AccessThe cross-sectional and prospective associations of parental practices and environmental factors with 24-hour movement behaviours among school-aged Asian children
Parental practices and neighbourhood environmental factors may influence children’s movement behaviours. We aimed to investigate the cross-sectional and prospective associations of parental practices and neigh...
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Open AccessNon-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review
Non-invasive, beat-to-beat variations in physiological indices provide an opportunity for more accessible assessment of autonomic dysfunction. The potential association between the changes in these parameters ...
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Open AccessExploring Attitudes Toward “Sugar Relationships” Across 87 Countries: A Global Perspective on Exchanges of Resources for Sex and Companionship
The current study investigates attitudes toward one form of sex for resources: the so-called sugar relationships, which often involve exchanges of resources for sex and/or companionship. The present study exam...
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Prevalence of true resistant hypertension in those referred for uncontrolled hypertension in Malaysia: A comparison using different definitions
Resistant hypertension is a well-recognised clinical challenge. However, the definition and epidemiology of true resistant hypertension (RH) are less understood, especially in Asia. This cross-sectional study ...
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Open AccessWhy more successful? An analysis of participants’ self-monitoring data in an online weight loss intervention
Self-monitoring is crucial for behavioral weight loss. However, few studies have examined the role of self-monitoring using mixed methods, which may hinder our understanding of its impact.
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Open AccessTrajectories of lifestyle patterns from 2 to 8 years of age and cardiometabolic risk in children: the GUSTO study
Tracking combinations of lifestyle behaviours during childhood (“lifestyle pattern trajectories”) can identify subgroups of children that might benefit from lifestyle interventions aiming to improve health out...
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