164 Result(s)
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Article
New Frontiers on Intracellular cGAS Activation: Molecular Mechanisms, Cellular Signaling, and Therapeutic Strategies
Cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a pivotal role in the innate immune system. As the primary DNA sensor in cells, cGAS binds to dsDNA in the cytoplasm and forms cGAS-DNA liquid-liquid phase separati...
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Research on the Microstructure and Properties of Stellite6/WC Composite Coatings via Laser Cladding
This study applied a stellite6/WC composite coating, renowned for its wear and corrosion resistance, onto Q960 high-strength steel through laser cladding technology. The study aimed to investigate the influenc...
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Article
Integrative Analysis of the Microbiome and Metabolome of Broiler Intestine: Insights into the Mechanisms of Probiotic Action as an Antibiotic Substitute
Antibiotic substitutes have become a research focus due to restrictions on antibiotic usage. Among the antibiotic substitutes on the market, probiotics have been extensively researched and used. However, the m...
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Effect of Variable Rate Non-isothermal Aging on the Microstructure and Properties of Al-Zn-Mg-Cu Alloy
The effect of variable rate nonisothermal aging (VR-NIA) on the properties and microstructure of Al-Zn-Mg-Cu alloy was studied through testing, such as hardness, friction and wear, intergranular corrosion (IGC...
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Article
Tracking endogenous proteins based on RNA editing-mediated genetic code expansion
Protein labeling approaches are important to study proteins in living cells, and genome editing tools make it possible to tag endogenous proteins to address the concerns associated with overexpression. Here we...
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Article
Two New Antibacterial Isoindolin-1-Ones from Sun-Cured Tobacco and Their Potential Application in Antiseptic Cigarette Tip** Paper
Two new isoindolin-1-ones (1 and 2), were isolated from the stems of Nicotiana tabacum (a cultivar of sun-cured tobacco with high resistance to black shank diseases, which originated from Huize local sun-cured to...
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Article
Fabrication of a dual mimetic enzyme sensor based on gold nanoparticles modified with Cu(II)-coordinated methanobactin for gallic acid detection
Gallic acid (GA) is a bioactive functional ingredient widely used in pharmacology and food. For GA detection, the accuracy and selectivity can be improved from the enzyme based electrochemical sensor. However,...
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Article
Intracellular redox potential-driven live-cell synthesis of CdSe quantum dots in Staphylococcus aureus
Biosynthesized semiconductor quantum dots (QDs) have bright fluorescence, adjustable particle sizes, and environmental friendliness, endowing them with convenience and potential for biological applications. Du...
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Article
Automated synthesis of oxygen-producing catalysts from Martian meteorites by a robotic AI chemist
Living on Mars requires the ability to synthesize chemicals that are essential for survival, such as oxygen, from local Martian resources. However, this is a challenging task. Here we demonstrate a robotic art...
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Article
Transformation of reactive oxygen species caused by assembly of excitation modules into supramolecular organic frameworks for photocatalysis
The efficient control of singlet oxygen (1O2) and superoxide radical ( \({\rm O}_{2}^{\cdot-}\) ...
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Article
Oral Administration of the Antimicrobial Peptide Mastoparan X Alleviates Enterohemorrhagic Escherichia coli–Induced Intestinal Inflammation and Regulates the Gut Microbiota
The gut microbiota plays an important role in intestinal immune system development and in driving inflammation. Antibiotic administration for therapeutic purposes causes an imbalance in the gut microbiota. Ant...
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Article
Super high-speed self-powered photodetector based on solution-processed transparent p-type amorphous phosphorous-doped SnO film
It is challenging to simply prepare high-performance optoelectronic p-type oxide semiconductors because their strong hole localization makes it difficult to generate mobile hole carriers. In this study, amorph...
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Article
Anti-Stenotrophomonas maltophilia Mechanism of Rose Essential Oil: A Metabolomic Study
Stenotrophomonas maltophilia (S. maltophilia) is a spoilage microorganism widely distributed in vegetables, dairy products, and various environments and can cause serious foodborne illnesses. Renowned for its env...
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Dipyridyl Azo Compound 4,4′-Azopyridine as a Potential Coating Material for Toilet Sanitizer
Good toilet hygiene can reduce the risk of pathogenic transmission. During flushing, pathogenic bacteria can be spread by the water droplets, especially in the toilet seat. Escherichia coli (E. coli) is one of th...
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Article
A Novel Magnetization-Modified Attapulgite as an Excellent Adsorbent for Tetracycline in Water
The massive use of antibiotics has led to contamination of water resources, and concerns have been raised about how to treat antibiotic residues in water. In this study, a novel magnetic attapulgite composite ...
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Article
Bio-based Copolyesters from p-Hydroxybenzaldehyde: Synthesis, Characterization and Thermo-Mechanical Properties
Petroleum-based polyesters are widely used in daily life. However, their reliance on petroleum resources and non-biodegradability have raised concerns. Due to the advantages of being renewable, degradable, and...
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Article
A blood-brain barrier crossing peptide
The development of non-invasive brain-targeting delivery approaches is very important for the treatment of diseases related to the central nervous system (CNS), and receptor-mediated transcytosis (RMT) holds a...
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Article
Reduced graphene oxide-mediated magnetoelectric effect drives neural differentiation of mesenchymal stem cells
Neurodegenerative illnesses are among the most difficult conditions to treat in humans. As mesenchymal stem cells (MSCs) are easily acquired for autologous stem cell transplantation, MSC treatment is regarded ...
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Article
Evaluation of antioxidant and anti-obesity potential of Sargassum extracts
Sargassum are brown algae belonging to the class Phaeophyceae. Brown algae are rich in nutrients and widely used in food. Most previous experiments have focused on the functional evaluation of organic solvent ext...
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Dye-encapsulated metal–organic framework composites for highly sensitive and selective sensing of oxytetracycline based on ratiometric fluorescence
Herein, we reported a class of well-fluorescence-stabilized rare-earth-free ratiometric fluorescent probe for highly sensitive visual detection of oxytetracycline (OTC), which was fabricated by encapsulation o...
