180 Result(s)
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Article
Early Therapeutic Drug Monitoring Optimizes Teicoplanin Use in Febrile Neutropenic Patients with Hematological Malignancies
A target trough concentration (Cmin) of teicoplanin ≥ 15–20 mg/L between the fourth and sixth day has been suggested for severe infections or management of febrile neutropenia (FN). Owing to no reports discussing...
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Article
A prediction model of elderly hip fracture mortality including preoperative red cell distribution width constructed based on the random survival forest (RSF) and Cox risk ratio regression
An independent correlation between pre-RDW and 1-year mortality after surgery in elderly hip fracture can be used to predict mortality in elderly hip fracture patients and has predictive significance in anemia...
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Open AccessClinical characteristics and risk factors associated with bone erosion in patients with tophi
If a large amount of urate crystals is deposited in a joint cavity for an extended period of time, bone erosion will occur and gradually cause skeletal muscle necrosis and joint deformity. The aim of this stud...
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Article
Open AccessVaccination and the risk of systemic lupus erythematosus: a meta-analysis of observational studies
This meta-analysis aims to explore the potential link between vaccines and systemic lupus erythematosus (SLE).
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Article
Phenotype of Takayasu-like vasculitis and cardiopathy in patients with Blau syndrome
We aimed to determine the prevalence of cardiovascular involvement in our Blau syndrome (BS) cohort and provide detailed analysis of their cardiovascular manifestations and outcome. We also tried to find out t...
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Article
Intrathecal injection of methotrexate and dexamethasone for vasculitis granuloma of the fourth ventricle: a case report and literature review
Granulomatosis with polyangiitis (GPA) is a pauci-immune small vessel vasculitis characterised by neutrophil-mediated vasculitis and granuloma. The presence of intracranial parenchymal space-occupying lesions ...
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Article
Open AccessEffectiveness of opportunistic osteoporosis screening on chest CT using the DCNN model
To develop and evaluate a deep learning model based on chest CT that achieves favorable performance on opportunistic osteoporosis screening using the lumbar 1 + lumbar 2 vertebral bodies fusion feature images,...
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Article
Open AccessEstablishment and pathophysiological evaluation of a novel model of acute compartment syndrome in rats
Researches have used intra-compartmental infusion and ballon tourniquest to create high intra-compartmental pressure in animal models of Acute Compartment Syndrome (ACS). However, due to the large differences ...
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Open AccessFemoral neck system versus multiple cannulated screws for the fixation of Pauwels classification type II femoral neck fractures in older female patients with low bone mass
Femoral neck fractures in older adult patients are a major concern and often necessitate surgical intervention. This study compared the clinical outcomes of 2 surgical techniques: the femoral neck system (FNS)...
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Article
Open AccessTopical Chinese patent medicines for chronic musculoskeletal pain: systematic review and trial sequential analysis
Chronic musculoskeletal pain (CMP) is defined as persistent or recurrent pain that occurs in the joints, musculo-soft tissue, spine or bones for more than three months and is not completely curable. Although t...
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Open AccessFructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)
To identify the role of gluconeogenesis in chondrocytes in osteoarthritis (OA).
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Article
Open AccessUpregulating miR-181b promotes ferroptosis in osteoarthritic chondrocytes by inhibiting SLC7A11
Osteoarthritis (OA) is a common disease with a complex pathology. This study aimed to investigate the correlation between the aberrant upregulation of miR-181b and ferroptosis in chondrocytes during the progre...
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Article
Open AccessPotential regulatory role of the Nrf2/HMGB1/TLR4/NF-κB signaling pathway in lupus nephritis
Systemic lupus erythematosus is an autoimmune disease that involves multiple organ systems. One of its major complications, lupus nephritis (LN), is associated with a high mortality rate, and children-onset LN...
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Article
Open AccessBrown Sequard syndrome in a patient with Klippel-Feil syndrome following minor trauma: a case report and literature review
There are some cases of Klippel-Feil syndrome with spinal cord injury in clinical work. However, there is no literature report on Brown-Sequard syndrome after trauma. We report a case of Brown-Sequard syndrome...
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Open AccessEfficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study
Low urine pH, which may be mediated by metabolic syndrome (MetS), is common in gout. Tart cherries are shown to improve MetS symptoms and possess anti-inflammatory properties. However, the efficacy of tart che...
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Article
Open AccessLarge-Scale, Multicenter, Prospective Registry Study of Ripretinib in Advanced GIST: A Real-World Study from China
Tyrosine-kinase inhibitors (TKIs) have become the standard treatment for patients with advanced gastrointestinal stromal tumor (GIST); however, secondary mutations can still drive disease progression. Studies ...
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Open AccessComprehensive analysis on subchondral bone marrow lesions of human osteoarthritis by integrating bulk and single-cell transcriptomes
This study aims to demonstrate the cellular composition and underlying mechanisms in subchondral bone marrow lesions (BMLs) of knee osteoarthritis (OA).
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Article
Open AccessThe correlation of two bone turnover markers with bone mineral density: a population-based cross-sectional study
Exploring the correlation between bone turnover marks (BTMs) with lumbar BMD in middle-aged populations.
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Open AccessComparison of the different monosodium urate crystals in the preparation process and pro-inflammation
The deposition of monosodium urate (MSU) crystals within synovial joints and tissues is the initiating factor for gout arthritis. Thus, MSU crystals are a vital tool for studying gout’s molecular mechanism in ...
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Open AccessAssociation between weight-adjusted-waist index and the prevalence of rheumatoid arthritis and osteoarthritis: a population-based study
The weight-adjusted-waist Index (WWI), an innovative metric for assessing obesity, exhibits superior efficacy in appraising lean muscle and adipose tissue mass relative to both the Body Mass Index (BMI) and Wa...
