210 Result(s)
within
**-Lin Wang
Life Sciences
Microarrays
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Article
Open AccessSNPHunter: a bioinformatic software for single nucleotide polymorphism data acquisition and management
Single nucleotide polymorphisms (SNPs) provide an important tool in pinpointing susceptibility genes for complex diseases and in unveiling human molecular evolution. Selection and retrieval of an optimal SNP s...
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Open AccessMolecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)
Severe acute respiratory syndrome (SARS), a recent epidemic human disease, is caused by a novel coronavirus (SARS-CoV). First reported in Asia, SARS quickly spread worldwide through international travelling. A...
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Open AccessAnalysis of 10,000 ESTs from lymphocytes of the cynomolgus monkey to improve our understanding of its immune system
The cynomolgus monkey (Macaca fascicularis) is one of the most widely used surrogate animal models for an increasing number of human diseases and vaccines, especially immune-system-related ones. Towards a better ...
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Open AccessIdentification of rat lung-specific microRNAs by microRNA microarray: valuable discoveries for the facilitation of lung research
An important mechanism for gene regulation utilizes small non-coding RNAs called microRNAs (miRNAs). These small RNAs play important roles in tissue development, cell differentiation and proliferation, lipid a...
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Open AccessHeritable clustering and pathway discovery in breast cancer integrating epigenetic and phenotypic data
In order to recapitulate tumor progression pathways using epigenetic data, we developed novel clustering and pathway reconstruction algorithms, collectively referred to as heritable clustering. This approach g...
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Open AccessConiferEST: an integrated bioinformatics system for data reprocessing and mining of conifer expressed sequence tags (ESTs)
With the advent of low-cost, high-throughput sequencing, the amount of public domain Expressed Sequence Tag (EST) sequence data available for both model and non-model organism is growing exponentially. While t...
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Open AccessComplete sequence and organization of Antheraea pernyi nucleopolyhedrovirus, a dr-rich baculovirus
The completion and reporting of baculovirus genomes is extremely important as it advances our understanding of gene function and evolution. Due to the large number of viral genomes now sequenced it is very imp...
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Open AccessGlobal transcription profiling reveals differential responses to chronic nitrogen stress and putative nitrogen regulatory components in Arabidopsis
A large quantity of nitrogen (N) fertilizer is used for crop production to achieve high yields at a significant economic and environmental cost. Efforts have been directed to understanding the molecular basis ...
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Open AccessUnravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering
It becomes increasingly clear that our current taxonomy of clinical phenotypes is mixed with molecular heterogeneity. Of vital importance for refined clinical practice and improved intervention strategies is t...
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Open AccessAn optimized procedure greatly improves EST vector contamination removal
The enormous amount of sequence data available in the public domain database has been a gold mine for researchers exploring various themes in life sciences, and hence the quality of such data is of serious con...
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Open AccessArsenic-induced changes in the gene expression of lung epithelial L2 cells: implications in carcinogenesis
Arsenic is a carcinogen that is known to induce cell transformation and tumor formation. Although studies have been performed to examine the modulation of signaling molecules caused by arsenic exposure, the mo...
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Open AccesseasyExon – A Java-based GUI tool for processing and visualization of Affymetrix exon array data
Alternative RNA splicing greatly increases proteome diversity and thereby contribute to species- or tissue-specific functions. The possibility to study alternative splicing (AS) events on a genomic scale using...
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Open AccessA novel regulatory event-based gene set analysis method for exploring global functional changes in heterogeneous genomic data sets
Analyzing gene expression data by assessing the significance of pre-defined gene sets, rather than individual genes, has become a main approach in microarray data analysis and this has promisingly derive new b...
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Open AccessUsing random forest for reliable classification and cost-sensitive learning for medical diagnosis
Most machine-learning classifiers output label predictions for new instances without indicating how reliable the predictions are. The applicability of these classifiers is limited in critical domains where inc...
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Open AccessMost parsimonious haplotype allele sharing determination
The "common disease – common variant" hypothesis and genome-wide association studies have achieved numerous successes in the last three years, particularly in genetic map** in human diseases. Nevertheless, t...
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Open AccessModerate strength (0.23–0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells
Compelling evidence exists that magnetic fields modulate living systems. To date, however, rigorous studies have focused on identifying the molecular-level biosensor (e.g., radical ion pairs or membranes) or o...
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Open AccessPrediction of protein binding sites in protein structures using hidden Markov support vector machine
Predicting the binding sites between two interacting proteins provides important clues to the function of a protein. Recent research on protein binding site prediction has been mainly based on widely known mac...
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Open AccessDIGAP - a Database of Improved Gene Annotation for Phytopathogens
Bacterial plant pathogens are very harmful to their host plants, which can cause devastating agricultural losses in the world. With the development of microbial genome sequencing, many strains of phytopathogen...
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Open AccessExtracting consistent knowledge from highly inconsistent cancer gene data sources
Hundreds of genes that are causally implicated in oncogenesis have been found and collected in various databases. For efficient application of these abundant but diverse data sources, it is of fundamental impo...
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Open AccessEST analysis reveals putative genes involved in glycyrrhizin biosynthesis
Glycyrrhiza uralensis is one of the most popular medicinal plants in the world and is also widely used in the flavoring of food and tobacco. Due to limited genomic and transcriptomic data, the biosynthetic pathwa...
