162 Result(s)
within
Life Sciences
Animal Genetics and Genomics
Microarrays
**-Lin Wang
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Article
Open AccessMolecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)
Severe acute respiratory syndrome (SARS), a recent epidemic human disease, is caused by a novel coronavirus (SARS-CoV). First reported in Asia, SARS quickly spread worldwide through international travelling. A...
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Open AccessAnalysis of 10,000 ESTs from lymphocytes of the cynomolgus monkey to improve our understanding of its immune system
The cynomolgus monkey (Macaca fascicularis) is one of the most widely used surrogate animal models for an increasing number of human diseases and vaccines, especially immune-system-related ones. Towards a better ...
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Open AccessIdentification of rat lung-specific microRNAs by microRNA microarray: valuable discoveries for the facilitation of lung research
An important mechanism for gene regulation utilizes small non-coding RNAs called microRNAs (miRNAs). These small RNAs play important roles in tissue development, cell differentiation and proliferation, lipid a...
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Open AccessConiferEST: an integrated bioinformatics system for data reprocessing and mining of conifer expressed sequence tags (ESTs)
With the advent of low-cost, high-throughput sequencing, the amount of public domain Expressed Sequence Tag (EST) sequence data available for both model and non-model organism is growing exponentially. While t...
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Open AccessComplete sequence and organization of Antheraea pernyi nucleopolyhedrovirus, a dr-rich baculovirus
The completion and reporting of baculovirus genomes is extremely important as it advances our understanding of gene function and evolution. Due to the large number of viral genomes now sequenced it is very imp...
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Open AccessGlobal transcription profiling reveals differential responses to chronic nitrogen stress and putative nitrogen regulatory components in Arabidopsis
A large quantity of nitrogen (N) fertilizer is used for crop production to achieve high yields at a significant economic and environmental cost. Efforts have been directed to understanding the molecular basis ...
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Open AccessUnravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering
It becomes increasingly clear that our current taxonomy of clinical phenotypes is mixed with molecular heterogeneity. Of vital importance for refined clinical practice and improved intervention strategies is t...
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Open AccessAn optimized procedure greatly improves EST vector contamination removal
The enormous amount of sequence data available in the public domain database has been a gold mine for researchers exploring various themes in life sciences, and hence the quality of such data is of serious con...
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Open AccessArsenic-induced changes in the gene expression of lung epithelial L2 cells: implications in carcinogenesis
Arsenic is a carcinogen that is known to induce cell transformation and tumor formation. Although studies have been performed to examine the modulation of signaling molecules caused by arsenic exposure, the mo...
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Open AccessA novel regulatory event-based gene set analysis method for exploring global functional changes in heterogeneous genomic data sets
Analyzing gene expression data by assessing the significance of pre-defined gene sets, rather than individual genes, has become a main approach in microarray data analysis and this has promisingly derive new b...
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Open AccessModerate strength (0.23–0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells
Compelling evidence exists that magnetic fields modulate living systems. To date, however, rigorous studies have focused on identifying the molecular-level biosensor (e.g., radical ion pairs or membranes) or o...
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Open AccessDIGAP - a Database of Improved Gene Annotation for Phytopathogens
Bacterial plant pathogens are very harmful to their host plants, which can cause devastating agricultural losses in the world. With the development of microbial genome sequencing, many strains of phytopathogen...
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Open AccessEST analysis reveals putative genes involved in glycyrrhizin biosynthesis
Glycyrrhiza uralensis is one of the most popular medicinal plants in the world and is also widely used in the flavoring of food and tobacco. Due to limited genomic and transcriptomic data, the biosynthetic pathwa...
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Open AccessInferring linkage disequilibrium from non-random samples†
Linkage disequilibrium (LD) plays a fundamental role in population genetics and in the current surge of studies to screen for subtle genetic variants affecting complex traits. Methods widely implemented in LD ...
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Open AccessA draft physical map of a D-genome cotton species (Gossypium raimondii)
Genetically anchored physical maps of large eukaryotic genomes have proven useful both for their intrinsic merit and as an adjunct to genome sequencing. Cultivated tetraploid cottons, Gossypium hirsutum and G. ba...
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Open AccessA molecular inversion probe assay for detecting alternative splicing
A sensitive, high-throughput method for monitoring pre-mRNA splicing on a genomic scale is needed to understand the spectrum of alternatively spliced mRNA in human cells.
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Open AccessTissue-specific gene expression templates for accurate molecular characterization of the normal physiological states of multiple human tissues with implication in development and cancer studies
To elucidate the molecular complications in many complex diseases, we argue for the priority to construct a model representing the normal physiological state of a cell/tissue.
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Open AccessTranscriptome analysis and comparison reveal divergence between two invasive whitefly cryptic species
Invasive species are valuable model systems for examining the evolutionary processes and molecular mechanisms associated with their specific characteristics by comparison with closely related species. Over the...
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Open AccessA physical map of Brassica oleracea shows complexity of chromosomal changes following recursive paleopolyploidizations
Evolution of the Brassica species has been recursively affected by polyploidy events, and comparison to their relative, Arabidopsis thaliana, provides means to explore their genomic complexity.
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Open AccessDifferentially expressed profiles in the larval testes of Wolbachia infected and uninfected Drosophila
Wolbachia are endosymbiotic bacteria that are frequently found in arthropods and nematodes. These maternally inherited bacteria manipulate host reproduction by several mechanisms including cytoplasmic incompatibi...
