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25,141 Result(s)
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Article
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer’s Disease
Neuroinflammation and endothelial cell apoptosis are prominent features of blood–brain barrier (BBB) disruption, which have been described in Alzheimer’s disease (AD) and can predict cognitive decline. Recent ...
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Efficacy and safety of dabigatran and rivaroxaban in atrial fibrillation patients with impaired liver function: a multicenter retrospective cohort study
The efficacy and safety of direct oral anticoagulants (DOACs) in atrial fibrillation (AF) patients with impaired liver function (ILF) have not been sufficiently studied. The aim of this study was to evaluate t...
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Thermally modulated photoelectronic synaptic behavior in HfS2/VO2 heterostructure
Neuromorphic computing is known for its efficient computational speed, low latency, and reduced power consumption, which is considered a pivotal technology to overcome the von Neumann bottleneck. Artificial sy...
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TiO2-Fe2TiO5 heterostructure hollow spheres enable high-performance lithium-sulfur batteries via interfacial engineering
The shuttle effect of lithium polysulfides between sulfur cathode and lithium anode is a notorious problem in the commercial application of lithium-sulfur batteries. Herein, heterostructured TiO2-Fe2TiO5 hollow s...
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Microstructure and room temperature fracture toughness of Nb–Si-based alloys with Sr addition
Nb–Si-based alloys show great potential to surpass the widely used Ni-based superalloys. The element Sr is widely applied in aluminum and magnesium alloys, but reports about the effects of Sr on Nb–Si-based al...
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Pharmacokinetics of nirmatrelvir/ritonavir and the drug-drug interaction with calcineurin inhibitor in renal transplant recipients
To describe the pharmacokinetic (PK) characteristics of nirmatrelvir/ritonavir in renal transplant recipients and explore the potential factors that related to the PK variance of nirmatrelvir/ritonavir and its...
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Investigating the brain functional abnormalities underlying pain hypervigilance in chronic neck and shoulder pain: a resting-state fMRI study
To investigate pain hypervigilance in individuals suffering from chronic neck and shoulder pain (CNSP) and its underlying brain mechanism.
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Open AccessPedigree analysis exploring the inconsistency between diverse phenotypes and testing criteria for germline TP53 mutations in Chinese women with breast cancer
In the present study, we addressed the inconsistency between the testing criteria and diverse phenotypes for germline TP53 mutation in patients with breast cancer in the Chinese population.
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Article
Robust Heterogeneous Model Fitting for Multi-source Image Correspondences
Traditional feature detection and description methods, such as scale-invariant feature transform, are susceptible to nonlinear radiation distortions (NRDs) and geometric distortions (GDs), which in turn genera...
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Article
Oxidation resistant low-alloyed Ti alloys with good ductility
Oxidation resistance enhancement of pure Ti often comes at the cost of reduced ductility, which is frequently the problem through alloying with sole Al, Si, W, Mo and B. To overcome the short coming of single ...
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Article
Metabolic engineering of Saccharomyces cerevisiae for high-level production of (+)-ambrein from glucose
(+)-Ambrein is the primary component of ambergris, a rare product found in sperm whales (Physeter microcephalus). Microbial production using sustainable resources is a promising way to replace animal extraction a...
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Elimination of cracks in stainless steel casings via 3D printed sand molds with an internal topology structure
The important supporting component in a gas turbine is the casing, which has the characteristics of large size, complex structure, and thin wall. In the context of existing 3DP sand casting processes, casting ...
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Article
Laser additive manufacturing of titanium alloys: process, materials and post-processing
Laser additive manufacturing (LAM) of titanium (Ti) alloys has emerged as a transformative technology with vast potential across multiple industries. To recap the state of the art, Ti alloys processed by two e...
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Open AccessEnhanced electrocatalytic biomass oxidation at low voltage by Ni2+-O-Pd interfaces
Challenges in direct catalytic oxidation of biomass-derived aldehyde and alcohol into acid with high activity and selectivity hinder the widespread biomass application. Herein, we demonstrate that a Pd/Ni(OH)2 ca...
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Open AccessIdentification of candidate single-nucleotide polymorphisms (SNPs) and genes associated with sugarcane leaf scald disease
Leaf scald, caused by Xanthomonas albilineans, is a severe disease affecting sugarcane worldwide. One of the most practical ways to control it is by develo** resistant sugarcane cultivars. It is essential to id...
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Open AccessExploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors
Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter overexpression in tumors contributes to resi...
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Open AccessSilicon photocathode functionalized with osmium complex catalyst for selective catalytic conversion of CO2 to methane
Solar-driven CO2 reduction to yield high-value chemicals presents an appealing avenue for combating climate change, yet achieving selective production of specific products remains a significant challenge. We show...
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Article
Vortex-Inspired Hydrodynamic Drafting Spinning Platform for Large-Scale Preparation of Hydrogel Fibers
Hydrogel fibers have gained considerable attention, but their large-scale production and industrial application are currently constrained. The key lies in precise diameter control and industrial manufacturing ...
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Article
Evaluation of NLLoc positioning method and seismogenic structure analysis of Luanzhou MS 4.3 earthquake
NLLoc is a nonlinear search positioning method. In this study, we use simulated arrival time data to quantitatively evaluate the NLLoc method from three aspects: arrival time picking accuracy, station distribu...
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Open AccessMulticenter study on clinical outcomes and poor prognostic factors in patients with Klebsiella pneumoniae bacteremia receiving cefoperazone/sulbactam treatment
Infections caused by Klebsiella pneumoniae are common and result in high mortality rates. In vitro studies demonstrated the potency of cefoperazone/sulbactam (CPZ/SUL) against Klebsiella pneumoniae. However, the ...