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Article
Open AccessChildhood adversity and suicidal ideation in older Korean adults: unraveling the mediating mechanisms of mental health, physical health, and social relationships
Suicide rates in older adults are much higher than those in younger age groups. Given the rapid increase in the proportion of older adults in Korea and the high suicide rate of this age group, it is worth inve...
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Traditional Korean diet high in one-carbon nutrients increases global DNA methylation: implication for epigenetic diet
DNA methylation is a major epigenetic phenomenon through which diet affects health and disease. This study aimed to determine the epigenetic influence of the traditional Korean diet (K-diet) on global DNA meth...
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Article
Open AccessResponse surface methodology mediated optimization of phytosulfokine and plant growth regulators for enhanced protoplast division, callus induction, and somatic embryogenesis in Angelica Gigas Nakai
Angelica Gigas (Purple parsnip) is an important medicinal plant that is cultivated and utilized in Korea, Japan, and China. It contains bioactive substances especially coumarins with anti-inflammatory, anti-plate...
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Article
Open AccessFlow-Driven Deformation in Granular Porous Media: Dimensionless Analysis
Fluid injection can induce mechanical deformation in granular porous media due to the elevation of internal pore fluid pressure. This gains more significance when more than two immiscible fluids are involved, ...
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Article
Open AccessGenetic characterization of a locus responsible for low pungency using EMS-induced mutants in Capsicum annuum L.
The pepper mutants (‘221-2-1a’ and ‘1559-1-2h’) with very low pungency were genetically characterized. The Pun4 locus, responsible for the reduced pungency of the mutant fruits, was localized to a 208 Mb region o...
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Open AccessAuthor Correction: Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress
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Article
Open AccessCancer cell-specific and pro-apoptotic SMAC peptide-doxorubicin conjugated prodrug encapsulated aposomes for synergistic cancer immunotherapy
Immunogenic cell death (ICD) is a crucial approach to turn immunosuppressive tumor microenvironment (ITM) into immune-responsive milieu and improve the response rate of immune checkpoint blockade (ICB) therapy...
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Article
Pullout behavior of tree root-inspired anchors: development of root architecture models and centrifuge tests
Construction and installation of foundation and anchorage elements often require large amounts of material and energy, which can lead to negative environmental and economic impacts. In contrast, even with mate...
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Article
Open AccessUnraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses
The role of the serine/glycine metabolic pathway (SGP) has recently been demonstrated in tumors; however, the pathological relevance of the SGP in thyroid cancer remains unexplored. Here, we perform metabolomi...
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Article
Aminoethoxyvinylglycine and 1-methylcyclopropene treatments affect fruit quality and ethylene production in ‘Geum Hwang’ peach
This study evaluated the effect of preharvest aminoethoxyvinylglycine (AVG) and postharvest 1-methylcyclopropene (1-MCP) treatments on ethylene production in association with fruit quality changes during ‘Geum...
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Article
Open AccessEffect of sugammadex on postoperative complications in patients with severe burn who underwent surgery: a retrospective study
This retrospective study investigated the association of sugammadex with postoperative pulmonary complication risk between 2013 and 2021 in patients with severe burn of five hospitals. Postoperative pulmonary ...
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Article
Therapeutic effect of intraperitoneal dexamethasone on noise-induced permanent threshold shift in mice model
The purpose of the study was to which investigate whether dexamethasone, which has anti-inflammatory and immune response suppression roles, could treat noise-induced hearing loss caused by damage to hair cells...
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Article
Evaluation of the therapeutic efficacy of human skin equivalents manufactured through droplet-based bioprinting/nebulization technology
In the field of dermatology, many studies have been conducted on artificial skin to develop alternative animal testing methods for therapeutic agents for skin sensitization or skin regeneration. Recent advance...
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Article
Open AccessEvaluation of the reasons for preferring root canal treatment in mature permanent teeth potentially indicated for pulp preservation: a clinical case/photo-based questionnaire study
With advances in pulp preservation procedures (PPP), indications for PPP extend to exposed pulp with symptoms in teeth with carious lesions. Scenario/text-based questionnaire studies report a high preference f...
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Article
Open AccessLoss-of-function gs3 allele decreases methane emissions and increases grain yield in rice
Rice paddies are a major source of methane emissions. To meet the food demand of the growing population and to cope with global warming, reducing greenhouse gases and enhancing yields are critical. Here we dem...
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Article
Open AccessAcceleration of wheat breeding: enhancing efficiency and practical application of the speed breeding system
Crop breeding should be accelerated to address global warming and climate change. Wheat (Triticum aestivum L.) is a major food crop. Speed breeding (SB) and speed vernalization (SV) techniques for spring and wint...
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Article
Exploring horticultural traits and disease resistance in Capsicum baccatum through segmental introgression lines
Segmental introgression and advanced backcross lines were developed and validated as important tools for improving agronomically important traits in pepper, offering improved sensitivity in detecting quantitat...
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Article
Open AccessSerum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancer
In this study, we aimed to investigate the feasibility of serum Krebs von den Lungen-6 (KL-6) as a potential biomarker for treatment-related ILD (TR-ILD) in lung cancer. We recruited patients with lung cancer ...
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Article
Long-term outcomes of a phase II study of neoadjuvant imatinib in large gastrointestinal stromal tumors of the stomach
Neoadjuvant treatment is recommended for large GISTs due to their friability and risk of extensive operations; however, studies on the indications and long-term results of this approach are lacking.
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Article
Open AccessLactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice
Mounting evidence suggests that probiotics are beneficial for treating Alzheimer’s disease (AD). However, the mechanisms by which specific probiotics modify AD pathophysiology are not clearly understood. In th...
