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Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Article
Open AccessIdentification of the central role of RNA polymerase mitochondrial for angiogenesis
Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA polymerase mitochondrial (POLRMT) serving as a key protein in regulating mitochondrial transcription and oxidative phospho...
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Article
Open AccessImmune escape of avian oncogenic Marek’s disease herpesvirus and antagonistic host immune responses
Marek’s disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek’s disease (MD), which is one of the most important immunosuppressive and rapid-onset neoplastic diseases in ...
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Article
Parameter optimization of the observation system for the South Yellow Sea strong shielding layer based on seismic illumination analysis
The seismic data of the Laoshan Uplift in the South Yellow Sea Basin reveal a low signal-to-noise ratio and low reflection signal energy in the deep Mesozoic–Paleozoic strata. The main reason is that the Mesoz...
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Article
The risk factors of early arterial stiffness in type 2 diabetes without diabetic macroangiopathy
Type 2 diabetes exposes the body to a state of high blood sugar for a long time and causes varying degrees of hardening of the arteries, making it more prone to cardiovascular emergencies.
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Article
Open AccessQuantitative systems pharmacology modeling of HER2-positive metastatic breast cancer for translational efficacy evaluation and combination assessment across therapeutic modalities
HER2-positive (HER2+) metastatic breast cancer (mBC) is highly aggressive and a major threat to human health. Despite the significant improvement in patients’ prognosis given the drug development efforts during t...
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Article
Open AccessAssociation of sudden sensorineural hearing loss with meteorological factors: a time series study in Hefei, China, and a literature review
Air pollution can cause disease and has become a major global environmental problem. It is currently believed that air pollution may be related to the progression of SSNHL. As a rapidly develo** city in rece...
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Article
Image restoration via combining a fractional order variational filter and a TGV penalty
In this paper, a novel variational model for the restoration of images contaminated with multiplicative noise (also known as speckle) is proposed. It combines a fractional-order total variational (FOTV) filter...
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Article
Metallic Sb-stabilized porous silicon with stable SEI and high electron/ion conductivity boosting lithium-ion storage performance
Silicon (Si) has mild discharge potential and high theoretical capacity, making it a highly desirable material for lithium-ion batteries (LIBs). Nevertheless, the excessive volume expansion, poor ion/electron ...
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Article
PRDX1 Interfering Peptide Disrupts Amino Acids 70–90 of PRDX1 to Inhibit the TLR4/NF-κB Signaling Pathway and Attenuate Neuroinflammation and Ischemic Brain Injury
Ischemic stroke ranks among the leading causes of death and disability in humans and is accompanied by motor and cognitive impairment. However, the precise mechanisms underlying injury after stroke and effecti...
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Article
Open AccessNLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis
Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown ...
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Article
Outcomes of Salvage Surgery Versus Non-Salvage Surgery for Initially Unresectable Hepatocellular Carcinoma After Conversion Therapy with Transcatheter Arterial Chemoembolization Combined with Lenvatinib Plus Anti-PD-1 Antibody: A Multicenter Retrospective Study
Combination treatment with transcatheter arterial chemoembolization (TACE), lenvatinib, and anti-programmed death-1 (anti-PD-1) antibodies (triple therapy) has a high rate of tumor response and converted resec...
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Article
Open AccessDesign and architecture of a slender and flexible underwater robot
This paper presents the design and analysis of a biomimetic underwater snake-like robot, addressing the main limitations of current underwater robotic systems in terms of maneuverability and adaptability in co...
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Article
Cactodera guizhouensis n. sp. (Nematoda: Heteroderinae), a new species of cyst-forming nematode parasitizing potato in Guizhou, China
A new cyst-forming nematode, Cactodera guizhouensis n. sp., isolated from the roots and surrounding soil of potato in Guizhou, China, is the first species of genus Cactodera found from the potato rhizosphere. The...
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Article
Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models
Autophagy impairment is a key factor in Alzheimer’s disease (AD) pathogenesis. TFEB (transcription factor EB) and TFE3 (transcription factor binding to IGHM enhancer 3) are nuclear transcription factors that r...
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Article
The level of CmFRQ is associated with the degeneration and rejuvenation of Cordyceps militaris fruiting body
Cordyceps militaris is a large fungus whose fruiting body is prone to degeneration. In the study of C. militaris FREQUENCY (CmFRQ), the negative regulator of C. militaris circadian clock, it was found that after ...
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Article
Clinical trajectories preceding incident dementia up to 15 years before diagnosis: a large prospective cohort study
Dementia has a long prodromal stage with various pathophysiological manifestations; however, the progression of pre-diagnostic changes remains unclear. We aimed to determine the evolutional trajectories of mul...
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Article
Corrosion behavior of as-cast Al0.75CoFeCr1.25Ni high entropy alloy in 0.5 mol/L NaOH solution
The corrosion behavior of an Al0.75CoFeCr1.25Ni high-entropy alloy (HEA) in 0.5 mol/L NaOH solution was investigated using a series of electrochemical and analytical techniques, including X-ray photoelectron spec...
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Article
Open AccessNanoparticle delivery of si-Notch1 modulates metabolic reprogramming to affect 5-FU resistance and cell pyroptosis in colorectal cancer
Nanocarrier delivery of small interfering RNAs (siRNAs) to silence cancer-associated genes is a promising method for cancer treatment. Here, we explored the role and mechanisms of PLAG NPs-delivered si-Notch1 ...
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Article
Characteristic, resource approaches and safety utilization assessment of non-ferrous metal smelting slags: A literature review
As an industrial byproduct of smelter operations, smelting slag has brought certain environmental issues including without taking safety precautions or using appropriate management. Through a thorough analysis...
