50 Result(s)
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Open AccessHeliorhodopsin-mediated light-modulation of ABC transporter
Heliorhodopsins (HeRs) have been hypothesized to have widespread functions. Recently, the functions for few HeRs have been revealed; however, the hypothetical functions remain largely unknown. Herein, we inves...
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Open AccessBenefits of statin therapy within a year after kidney transplantation
Cardiovascular disease remains a leading cause of morbidity and mortality after kidney transplantation (KT). Although statins reduce cardiovascular risk and have renal benefits in the general population, their...
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Open AccessEffect of statin use on head and neck cancer prognosis in a multicenter study using a Common Data Model
Few studies have found an association between statin use and head and neck cancer (HNC) outcomes. We examined the effect of statin use on HNC recurrence using the converted Observational Medical Outcome Partne...
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Open AccessHigh pretransplant FGF23 level is associated with persistent vitamin D insufficiency and poor graft survival in kidney transplant patients
Vitamin D3 (25[OH]D3) insufficiency and fibroblast growth factor 23 (FGF23) elevation are usually attenuated after kidney transplantation (KT). However, elevated FGF23 may be associated with poor graft outcomes a...
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Open AccessThe ultra-thin, minimally invasive surface electrode array NeuroWeb for probing neural activity
Electrophysiological recording technologies can provide valuable insights into the functioning of the central and peripheral nervous systems. Surface electrode arrays made of soft materials or implantable mult...
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Open AccessMachine learning approaches that use clinical, laboratory, and electrocardiogram data enhance the prediction of obstructive coronary artery disease
Pretest probability (PTP) for assessing obstructive coronary artery disease (ObCAD) was updated to reduce overestimation. However, standard laboratory findings and electrocardiogram (ECG) raw data as first-lin...
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Open AccessEnhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease
Ca2+ overload-induced mitochondrial dysfunction is considered as a major contributing factor in the pathogenesis of alcohol-associated liver disease (ALD). However, the initiating factors that drive mitochondrial...
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Open AccessCTCF controls three-dimensional enhancer network underlying the inflammatory response of bone marrow-derived dendritic cells
Dendritic cells are antigen-presenting cells orchestrating innate and adaptive immunity. The crucial role of transcription factors and histone modifications in the transcriptional regulation of dendritic cells...
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Open AccessMachine learning model for predicting ciprofloxacin resistance and presence of ESBL in patients with UTI in the ED
Increasing antimicrobial resistance in uropathogens is a clinical challenge to emergency physicians as antibiotics should be selected before an infecting pathogen or its antibiotic resistance profile is confir...
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Open AccessImpact of iron status on kidney outcomes in kidney transplant recipients
Iron plays an important role in hemodynamics and the immunity, independent of anemia. Since dynamic changes occur in iron storage after kidney transplantation (KT), we investigated the association between iron...
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Open AccessRegulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1
Aminoacyl-tRNA synthetases (ARSs) have evolved to acquire various additional domains. These domains allow ARSs to communicate with other cellular proteins in order to promote non-translational functions. Verte...
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Open AccessRobust Co alloy design for Co interconnects using a self-forming barrier layer
With recent rapid increases in Cu resistivity, RC delay has become an important issue again. Co, which has a low electron mean free path, is being studied as beyond Cu metal and is expected to minimize this incre...
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Open AccessEtiologies of altered level of consciousness in the emergency room
Altered levels of consciousness (ALCs) is a challenging issue; however, data describing its etiology and frequency are lacking. This study aimed to clarify and classify the etiologies of ALCs in the emergency ...
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Open AccessAge-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individual...
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Open AccessOral microbiome associated with lymph node metastasis in oral squamous cell carcinoma
Oral microbiota can alter cancer susceptibility and progression by modulating metabolism and inflammation. We assessed the association between the oral microbiome and lymph node (LN) metastasis in oral squamou...
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Open AccessA novel mineralocorticoid receptor antagonist, 7,3',4'-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids
Excess glucocorticoids (GCs) with either endogenous or exogenous origins deteriorate skin barrier function. GCs bind to mineralocorticoid and GC receptors (MRs and GRs) in normal human epidermal keratinocytes ...
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Open AccessEnhanced light extraction efficiency and viewing angle characteristics of microcavity OLEDs by using a diffusion layer
The viewing angle characteristics and light extraction efficiency of organic light-emitting diodes (OLEDs) with a micro-cavity structure were enhanced. This was accomplished by inserting a diffusion layer comp...
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Open AccessColor-tuning of natural variants of heliorhodopsin
Microbial rhodopsins are distributed through many microorganisms. Heliorhodopsins are newly discovered but have an unclear function. They have seven transmembrane helices similar to type-I and type-II rhodopsi...
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Open AccessImpact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes
Recently, waist to hip ratio (WHR) has been reported to be a better indicator of predicting cardiovascular outcomes than body mass index (BMI). We evaluated the effects of pre or post-transplant changes of WHR...
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Open AccessPlatycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells
The root of Platycodon grandiflorum (PG) has long been used as a traditional herbal medicine in Asian country. Platycondin D (PD), triterpenoid saponin that is a main constituent of PG, exhibits various biologica...
