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Article
Engineering miniature IscB nickase for robust base editing with broad targeting range
IscB has a similar domain organization to Cas9, but the small size of IscB is better suited for delivery by adeno-associated virus. To improve the low editing efficiency of OgeuIscB (IscB from human gut metage...
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Article
Open AccessZero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering
Mutations in amino acid sequences can provoke changes in protein function. Accurate and unsupervised prediction of mutation effects is critical in biotechnology and biomedicine, but remains a fundamental chall...
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Article
A deep learning model for translating CT to ventilation imaging: analysis of accuracy and impact on functional avoidance radiotherapy planning
Radiotherapy planning incorporating functional lung images has the potential to reduce pulmonary toxicity. Free-breathing 4DCT-derived ventilation image (CTVI) may help quantify lung function. This study intro...
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Article
Effects of offset design on the accuracy of bracket placement with a guided bonding device
This study aimed to evaluate the effects of offset design on the accuracy of bracket placement for computer-aided design and computer-aided manufacturing (CAD/CAM)-guided bonding devices (GBDs) in vitro.
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Article
Factors associated with the development of exudation in treatment-naive eyes with nonexudative macular neovascularization
To identify the predictive factors for development of exudation in patients with treatment-naïve nonexudative macular neovascularization (MNV).
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Article
Open AccessAplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3...
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Article
Dysregulation of the Gut Microbiota Contributes to Sevoflurane-Induced Cognitive Dysfunction in Aged Mice by Activating the NLRP3 Inflammasome
Postoperative cognitive dysfunction (POCD), a common complication in elderly patients after surgery, seriously affects patients’ quality of life. Long-term or repeated inhalation of sevoflurane can cause neuro...
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Article
Open AccessAuthor Correction: Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status
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Article
Open AccessDepletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status
Hepatocellular carcinoma (HCC) is characterized by high incidence and fatality rates worldwide. In our exploration of prognostic factors in HCC, the 26s proteasome subunit, non-ATPase 1 (PSMD1) protein emerged...
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Article
Open AccessA Response to: Letter to the Editor Regarding “Cost-Effectiveness Analysis of Pharmacokinetic-Guided Prophylaxis Versus Standard Prophylaxis in Adults with Severe Hemophilia A in China”
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Article
Vaccine Development for Severe Fever with Thrombocytopenia Syndrome Virus in Dogs
Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening viral zoonosis. The causative agent of this disease is the Dabie bandavirus, which is usually known as the SFTS virus (SFTSV). Although the...
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Article
Open AccessThe CompactLight Design Study
CompactLight is a Design Study funded by the European Union under the Horizon 2020 research and innovation funding programme, with Grant Agreement No. 777431. CompactLight was conducted by an International Col...
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Article
Open AccessMelt-quenched glass formation of a family of metal-carboxylate frameworks
Metal-organic framework (MOF) glasses are an emerging class of glasses which complement traditional inorganic, organic and metallic counterparts due to their hybrid nature. Although a few zeolitic imidazolate ...
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Article
Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n
Nondestructive and noninvasive neutron assays are essential applications of neutron techniques. Neutron resonance transmission analysis (NRTA) is a powerful nondestructive method for investigating the elementa...
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Article
Rethinking extent of resection of contrast-enhancing and non-enhancing tumor: different survival impacts on adult-type diffuse gliomas in 2021 World Health Organization classification
Extent of resection (EOR) of contrast-enhancing (CE) and non-enhancing (NE) tumors may have different impacts on survival according to types of adult-type diffuse gliomas in the molecular era. This study aimed...
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Article
Open AccessErratum: Towards a muon collider
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Article
Open AccessMetabolomic profiling of exosomes reveals age-related changes in ovarian follicular fluid
Female fertility declines with increased maternal age, and this decline is even more rapid after the age of 35 years. Follicular fluid (FF) is a crucial microenvironment that plays a significant role in the de...
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Article
Auto-suppression of Tet dioxygenases protects the mouse oocyte genome from oxidative demethylation
DNA cytosine methylation plays a vital role in repressing retrotransposons, and such derepression is linked with developmental failure, tumorigenesis and aging. DNA methylation patterns are formed by precisely...
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Chapter and Conference Paper
Cementing Practice of Easy-Leaking Formations Under Complex Geological Conditions
Jizhong buried-hill reservoir and Menggulin conglomerate heavy oil reservoir in Huabei Oilfield contain abundant residual oil and gas resources. In order to use the reserves as much as possible, CO2 injection gra...
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Article
An optimization method of trochoidal radius for trochoidal milling hole based on the adaptive feed rate scheduling
The machining time is mainly related to the tool path and the corresponding feed speed, while the trochoidal tool path depends on the trochoidal step and trochoidal radius. The material removal rate is periodi...
