389 Result(s)

Article

Correction: Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis

Chao Lu, Pengyun Qiao, Ruihai Fu, Yadi Wang, Jiayi Lu, ** Ling… in Cell Death & Disease (2024)

Article

Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity

Aging and obesity pose significant threats to public health and are major contributors to muscle atrophy. The trends in muscle fiber types under these conditions and the transcriptional differences between dif...

Feng-Min Zhang, Hao-Fan Wu, Ke-Fan Wang, Ding-Ye Yu… in Cell Death & Disease (2024)

Article

Dexmedetomidine improves the circulatory dysfunction of the glymphatic system induced by sevoflurane through the PI3K/AKT/ΔFosB/AQP4 pathway in young mice

Multiple sevoflurane exposures may damage the develo** brain. The neuroprotective function of dexmedetomidine has been widely confirmed in animal experiments and human studies. However, the effect of dexmede...

Shuying Wang, **ao** Yu, Lili Cheng, Weishu Ren, Gehua Wen, Xue Wu… in Cell Death & Disease (2024)

Article

Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization

Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...

Chunming Xu, Jie Wu, Jiye Ye, Yuancheng Si, **shi Zhang, Bowen Wu… in Cell Death & Disease (2024)

Article

Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway

Heat exposure is an environmental stressor that has been associated with cognitive impairment. However, the neural mechanisms that underlie this phenomenon have yet to be extensively investigated. The Morris w...

Hongxia Li, Wenlan Pan, Chenqi Li, Mengyu Cai, Wen**g Shi… in Cell Death Discovery (2024)

Article

An oncogenic role of lncRNA SNHG1 promotes ATG7 expression and autophagy involving tumor progression and sunitinib resistance of Renal Cell Carcinoma

Renal cell carcinoma (RCC) is a malignant tumor with high incidence in adult kidney. Long non-coding RNAs (lncRNAs) have recently been recognized as important regulators in the development of RCC. However, whe...

Pei Tian, **xing Wei, **g Li, Junkai Ren, Chaohong He in Cell Death Discovery (2024)

Article

NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1

Ovarian endometriosis is a common gynecological disease, and one of its most significant symptoms is infertility. In patients with endometriosis, defects in endometrial decidualization lead to impaired endomet...

Mengxue Wang, Fangyuan Sun, Shucai Zhang… in Cellular and Molecular Life Sciences (2024)

Article

Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancer

Single cell RNA sequencing (scRNA-seq), a powerful tool for studying the tumor microenvironment (TME), does not preserve/provide spatial information on tissue morphology and cellular interactions. To understan...

**g **ao, **nyang Yu, Fanlin Meng, Yuncong Zhang, Wenbin Zhou… in Cell Death & Disease (2024)

Article

The epigenetic regulators EP300/CREBBP represent promising therapeutic targets in MLL-rearranged acute myeloid leukemia

Acute myeloid leukemia (AML) with mixed-lineage leukemia (MLL) gene rearrangements (MLL-r) is an aggressive subtype of blood cancer with dismal prognosis, underscoring the urgent need for novel therapeutic strate...

Wenqi Wu, Yanan Jiang, Donghui **ng, Yixin Zhai, Huimeng Sun… in Cell Death Discovery (2024)

Article

The crosstalk between mitochondrial quality control and metal-dependent cell death

Mitochondria are the centers of energy and material metabolism, and they also serve as the storage and dispatch hubs of metal ions. Damage to mitochondrial structure and function can cause abnormal levels and ...

Qi-yuan Zhou, Chao Ren, **g-yan Li, Lu Wang, Yu Duan, Ren-qi Yao… in Cell Death & Disease (2024)

Article

FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression

FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, the functions and the molecular mechanisms regulated by FBXO32 in lung a...

Jie Wu, Ting Wen, Antonio Marzio, Dingli Song, Sisi Chen… in Cell Death & Disease (2024)

Article

STING agonist diABZI enhances the cytotoxicity of T cell towards cancer cells

Antigen-specific T cell receptor-engineered T cell (TCR-T) based immunotherapy has proven to be an effective method to combat cancer. In recent years, cross-talk between the innate and adaptive immune systems ...

Ling Wang, Zhaoduan Liang, Yunzhuo Guo, Jean de Dieu Habimana… in Cell Death & Disease (2024)

Article

CRL4^DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes

The DNA methylation is gradually acquired during oogenesis, a process sustained by successful follicle development. However, the functional roles of methyl-CpG-binding protein 2 (MeCP2), an epigenetic regulato...

Peipei Ren, **aomei Tong, Junjian Li, Huifang Jiang… in Cellular and Molecular Life Sciences (2024)

Article

NCAPD3 exerts tumor-promoting effects in prostatic cancer via dual impact on miR-30a-5p by STAT3-MALAT1 and MYC

Non-SMC condensin II complex subunit D3 (NCAPD3) is a subunit of the non-structural maintenance of chromosomes condensin II complex, which involves chromosome condensation and segregation during mitosis. NCAPD...

Yi Zhang, Yingying Shao, Jia Ren, Yuanyuan Fang, Bolin Yang… in Cell Death Discovery (2024)

Article

METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging

Senile osteoporosis is mainly caused by osteoblasts attenuation, which results in reduced bone mass and disrupted bone remodeling. Numerous studies have focused on the regulatory role of m6A modification in os...

Yaobin Wang, Yi Chen, Hefang **ao, Zhongcheng Liu, Xuening Liu… in Cell Death Discovery (2024)

Article

Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells

Acute pancreatitis (AP) continues to pose a major challenge as targeted therapeutic interventions are absent. Mitochondrial dysfunction and inflammasome-dependent pyroptosis are involved in the pathogenic mech...

Wuming Liu, Yifan Ren, Tao Wang, Mengzhou Wang, Yujia Xu, Jia Zhang… in Cell Death Discovery (2024)

Article

RIPK1 inhibitor ameliorates pulmonary injury by modulating the function of neutrophils and vascular endothelial cells

Acute lung injury (ALI) is an acute and progressive hypoxic respiratory failure that could progress to acute respiratory distress syndrome (ARDS) with a high mortality rate, thus immediate medical attention an...

Tao Yang, Cai-gui **ang, **ao-han Wang, Qing-qing Li, Shu-yue Lei… in Cell Death Discovery (2024)

Article

Mitochondria-associated endoplasmic reticulum membrane (MAM): a dark horse for diabetic cardiomyopathy treatment

Diabetic cardiomyopathy (DCM), an important complication of diabetes mellitus (DM), is one of the most serious chronic heart diseases and has become a major cause of heart failure worldwide. At present, the pa...

Yong Liu, **-Ling Huo, Kaidi Ren, Shaokang Pan, Hengdao Liu… in Cell Death Discovery (2024)

Article

Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model

Epigenetic dysregulation that leads to alterations in gene expression and is suggested to be one of the key pathophysiological factors of Parkinson’s disease (PD). Here, we found that α-synuclein preformed fib...

Zhixiong Zhang, Rui Wang, Hui Zhou, Dan Wu… in Cellular and Molecular Life Sciences (2024)

Article

Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice

Sarcopenia, a progressive and prevalent neuromuscular disorder, is characterized by age-related muscle wasting and weakening. Despite its widespread occurrence, the molecular underpinnings of this disease rema...

Jie Chen, Hong Chen, **a Dong, Tiankun Hui, Min Yan, Dongyan Ren… in Cell Death & Disease (2024)