125 Result(s)

Article

Correction: MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma

Qin Tang, Wan Li, **ang** Zheng, Liwen Ren… in Signal Transduction and Targeted Therapy (2024)

Article

The DNA damage-independent ATM signalling maintains CBP/DOT1L axis in MLL rearranged acute myeloid leukaemia

The long-term maintenance of leukaemia stem cells (LSCs) is responsible for the high degree of malignancy in MLL (mixed-lineage leukaemia) rearranged acute myeloid leukaemia (AML). The DNA damage response (DDR) a...

Guangming Wang, Wenjun Zhang, Jie Ren, Yu Zeng, **uyong Dang, … in Oncogene (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Retraction Note: Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer

X. Q. Zheng, J. P. Guo, H. Yang, M. Kanai, L. L. He, Y. Y. Li, J. M. Koomen… in Oncogene (2024)

Article

Correction: M⁷G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma

Mingyu He, Yang Wang, Jiajie **e, Jiaying Pu, Zhihua Shen, Ao Wang, Tao Li… in Oncogene (2024)

Article

Tissue factor overexpression promotes resistance to KRAS-G12C inhibition in non-small cell lung cancer

The recently approved KRAS^G12C mutation-specific inhibitors sotorasib and adagrasib (KRAS^G12C-I) represent a promising therapy for KRAS^G12C-driven non-small cell lung cancer (NSCLC). However, many eligible patien...

Yu Zhang, Liang Liu, **peng Pei, Zhiqiang Ren, Yan Deng, Ker Yu in Oncogene (2024)

Article

New insights into the correlations between circulating tumor cells and target organ metastasis

Organ-specific metastasis is the primary cause of cancer patient death. The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic f...

Qinru Zhan, Bixia Liu, **aohua Situ, Yuting Luo… in Signal Transduction and Targeted Therapy (2023)

Article

Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy

Despite the remarkable success of immune checkpoint inhibitors (ICIs), primary resistance to ICIs causes only subsets of patients to achieve durable responses due to the complex tumor microenvironment (TME). O...

Daoyuan **e, Yaomei Tian, Die Hu, Yuanda Wang… in Signal Transduction and Targeted Therapy (2023)

Article

Control of CD4⁺ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase

CD4⁺ T cells, particularly IL-17-secreting helper CD4⁺ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8⁺ ...

Hao-Yun Peng, Liqing Wang, Jugal Kishore Das… in Signal Transduction and Targeted Therapy (2023)

Article

Ras homolog family member J (RHOJ): a key regulator of chemoresistance associated with epithelial-mesenchymal transition

Sijia Liu, Jiang Ren, Long Zhang in Signal Transduction and Targeted Therapy (2023)

Article

Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study

Sorafenib therapy improves overall survival (OS) in patients with FLT3 internal tandem duplication (ITD) acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation. We explored ...

Ruoyang Shao, Yu Zhang, **** He, Fen Huang… in Signal Transduction and Targeted Therapy (2023)

Article

FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation

FBXO28 is a member of F-box proteins that are the substrate receptors of SCF (SKP1, CULLIN1, F-box protein) ubiquitin ligase complexes. Despite the implications of its role in cancer, the function of FBXO28 in...

**nran Qiao, **gyu Lin, Jiajia Shen, Yang Chen, Liyun Zheng, Hangjiang Ren… in Oncogene (2023)

Article

VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs tha...

Chunsik Lee, Rongyuan Chen, Guangli Sun… in Signal Transduction and Targeted Therapy (2023)

Article

Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer

The therapeutic efficacy of metformin in prostate cancer (PCa) appears uncertain based on various clinical trials. Metformin treatment failure may be attributed to the high frequency of transcriptional dysregu...

Jianheng Ye, Shanghua Cai, Yuanfa Feng… in Signal Transduction and Targeted Therapy (2023)

Article

Envonalkib versus crizotinib for treatment-naive ALK-positive non-small cell lung cancer: a randomized, multicenter, open-label, phase III trial

Anaplastic lymphoma kinase (ALK) rearrangements are present in about 5–6% of non-small cell lung cancer (NSCLC) cases and associated with increased risks of central nervous system (CNS) involvement. Envonalkib...

Yunpeng Yang, Jie Min, Nong Yang, Qitao Yu… in Signal Transduction and Targeted Therapy (2023)

Article

Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCII^hi neutrophils

Breast cancer can metastasize to various organs, including the lungs. The immune microenvironment of the organs to be metastasized plays a crucial role in the metastasis of breast cancer. Infection with pathog...

Teng Ma, Yu Tang, Taolin Wang, Yang Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

** Ren, Yingxia Hu, Lei Peng, Luojia Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Spinal cord injury: molecular mechanisms and therapeutic interventions

Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties of neural regeneration ...

**ao Hu, Wei Xu, Yilong Ren, Zhaojie Wang… in Signal Transduction and Targeted Therapy (2023)

Article

De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity

Oncogenic stress induces DNA damage repair (DDR) that permits escape from mitotic catastrophe and allows early precursor lesions during the evolution of cancer. SAMHD1, a dNTPase protecting cells from viral in...

**gwei Liu, Tingting Zhou, **ang Dong, Qiqiang Guo, Lixia Zheng, **aoxun Wang… in Oncogene (2023)

Article

Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma

Tumor thrombus of bone sarcomas represents a unique reservoir for various types of cancer and immune cells, however, the investigation of tumor thrombus at a single-cell level is very limited. And it is still ...

Tao Ji, Qianyu Shi, Song Mei, Jiuhui Xu, Haijie Liang, Lu **e, Tingting Ren… in Oncogenesis (2023)