323 Result(s)

Article

Apoptosis: The importance of being eaten

In vivo, cells undergoing apoptosis are usually recognised and swiftly ingested by macrophages or neighbouring cells acting as semi-professional phagocytes. This review debates evidence that the contents of apopt...

Yi Ren, John Savill in Cell Death & Differentiation (1998)

Article

Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4⁺CD25⁺ regulatory T cells

CD4⁺CD25⁺ regulatory T cells (Treg) are potent immunosuppressive cells active in controlling normal pathological immune responses. The mechanisms of this suppression have been investigated under various condition...

X Ren, F Ye, Z Jiang, Y Chu, S **ong, Y Wang in Cell Death & Differentiation (2007)

Article

Three-dimensional domain swap** as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease

Proteolytic processing of viral polyproteins is indispensible for the lifecycle of coronaviruses. The main protease (M^pro) of SARS-CoV is an attractive target for anti-SARS drug development as it is essential for...

Shengnan Zhang, Nan Zhong, Fei Xue, Xue Kang, **aobai Ren, Jiaxuan Chen… in Protein & Cell (2010)

Article

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

Interferon regulatory factor-1 (IRF-1) is a transcription factor that acts as a tumor suppressor and causes apoptosis in cancer cells. We evaluated IRF-1-induced apoptosis in gastric cancer cell lines. We esta...

J Gao, M Senthil, B Ren, J Yan, Q **ng, J Yu, L Zhang… in Cell Death & Differentiation (2010)

Article

The next-generation sequencing technology and application

As one of the key technologies in biomedical research, DNA sequencing has not only improved its productivity with an exponential growth rate but also been applied to new areas of application over the past few ...

**aoguang Zhou, Lufeng Ren, Qingshu Meng, Yuntao Li, Yude Yu, Jun Yu in Protein & Cell (2010)

Article

Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases

Omi, also known as high temperature requirement factor A2 (HtrA2), is a serine protease that was originally identified as a proapoptotic protein. Like Smac/Diablo, it antagonizes inhibitor of apoptosis protein...

B Li, Q Hu, H Wang, N Man, H Ren, L Wen, N Nukina, E Fei… in Cell Death & Differentiation (2010)

Article

Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner

Angiogenesis, a process by which the preexisting blood vasculature gives rise to new capillary vessels, is associated with a variety of physiologic and pathologic conditions. However, the molecular mechanism u...

Dengwen Li, Songbo **e, Yuan Ren, Lihong Huo, **min Gao, Dandan Cui… in Protein & Cell (2011)

Article

Animal models for the atherosclerosis research: a review

Atherosclerosis is a leading cause of death worldwide, and its mechanisms are still unclear. However, various animal models have significantly advanced our understanding of the mechanisms involved in atheroscl...

Li **angdong, Liu Yuanwu, Zhang Hua, Ren Liming, Li Qiuyan, Li Ning in Protein & Cell (2011)

Article

Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid

Local synthesis of interferon within B16 tumors mediates anti-tumor effects. Based on reports that stem cells are recruited to tumors, and because systemic administration of interferon causes dose-limiting und...

Christopher D Krause, Lara S Izotova, Gwangwen Ren… in Stem Cell Research & Therapy (2011)

Article

Erratum: Klotho suppresses RIG-I-mediated senescence-associated inammation

Nat. Cell Biol. 13, 254–262 (2011); published online 20 February 2011; corrected after print 16 March 2011 In the version of this article initially published online and in print, the middle graph in Figure 3b ...

Feng Liu, Su Wu, Hongwei Ren, Jun Gu in Nature Cell Biology (2011)

Article

Structural insight into substrate specificity of human intestinal maltase-glucoamylase

Human maltase-glucoamylase (MGAM) hydrolyzes linear alpha-1,4-linked oligosaccharide substrates, playing a crucial role in the production of glucose in the human lumen and acting as an efficient drug target fo...

Limei Ren, **aohong Qin, **aofang Cao, Lele Wang, Fang Bai, Gang Bai… in Protein & Cell (2011)

Article

MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer

Apoptosis has a vital role in maintaining tissue homeostasis, and dysregulation of the apoptotic pathway is now widely recognized as a key step in tumourigenesis. Increasingly, evidence has demonstrated that m...

H Zhang, Y Li, Q Huang, X Ren, H Hu, H Sheng, M Lai in Cell Death & Differentiation (2011)

Article

Crystal structures of d-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars

d-Psicose 3-epimerase (DPEase) is demonstrated to be useful in the bioproduction of d-psicose, a rare hexose sugar, from d-fructose, found plenty in nature. Clostridium cellulolyticum H10 has recently been identi...

Hsiu-Chien Chan, Yueming Zhu, Yumei Hu, Tzu-** Ko, Chun-Hsiang Huang… in Protein & Cell (2012)

Article

New insight into the oncogenic mechanism of the retroviral oncoprotein Tax

Human T cell leukemia virus type 1 (HTLV-1), an etiological factor that causes adult T cell leukemia and lymphoma (ATL), infects over 20 million people worldwide. About 1 million of HTLV-1-infected patients de...

Hua Cheng, Tong Ren, Shao-cong Sun in Protein & Cell (2012)

Article

Mesenchymal stem cells: a double-edged sword in regulating immune responses

Mesenchymal stem cells (MSCs) have been employed successfully to treat various immune disorders in animal models and clinical settings. Our previous studies have shown that MSCs can become highly immunosuppres...

W Li, G Ren, Y Huang, J Su, Y Han, J Li, X Chen, K Cao… in Cell Death & Differentiation (2012)

Article

The newly emerged SARS-Like coronavirus HCoV-EMC also has an “Achilles’ heel”: current effective inhibitor targeting a 3C-like protease

Zhilin Ren, Liming Yan, Ning Zhang, Yu Guo, Cheng Yang, Zhiyong Lou… in Protein & Cell (2013)

Article

Genome-wide association studies on prostate cancer: the end or the beginning?

Prostate cancer (PCa) is the second most frequently diagnosed malignancy in men. Genome-wide association studies (GWAS) has been highly successful in discovering susceptibility loci for prostate cancer. Curren...

Rui Chen, Shancheng Ren, Yinghao Sun in Protein & Cell (2013)

Article

A novel subset of helper T cells promotes immune responses by secreting GM-CSF

Helper T cells are crucial for maintaining proper immune responses. Yet, they have an undefined relationship with one of the most potent immune stimulatory cytokines, granulocyte macrophage-colony-stimulating ...

J Zhang, A I Roberts, C Liu, G Ren, G Xu, L Zhang… in Cell Death & Differentiation (2013)

Article

Endothelial progenitor cells in cardiovascular diseases: from biomarker to therapeutic agent

Regenerative medicine techniques to recover cardiac and vascular function are being increasingly investigated as management strategies for cardiovascular diseases. Circulating endothelial progenitor cells (EPC...

Hui-Bin Liu, Yuan-Feng Gong, Chang-Jiang Yu… in Regenerative Medicine Research (2013)

Article

Direct reprogramming of porcine fibroblasts to neural progenitor cells

**u-Ling Xu, Ji-** Yang, Li-Na Fu, Ruo-Tong Ren, Fei Yi… in Protein & Cell (2014)