142 Result(s)

Article

Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway

Heat exposure is an environmental stressor that has been associated with cognitive impairment. However, the neural mechanisms that underlie this phenomenon have yet to be extensively investigated. The Morris w...

Hongxia Li, Wenlan Pan, Chenqi Li, Mengyu Cai, Wen**g Shi… in Cell Death Discovery (2024)

Article

An oncogenic role of lncRNA SNHG1 promotes ATG7 expression and autophagy involving tumor progression and sunitinib resistance of Renal Cell Carcinoma

Renal cell carcinoma (RCC) is a malignant tumor with high incidence in adult kidney. Long non-coding RNAs (lncRNAs) have recently been recognized as important regulators in the development of RCC. However, whe...

Pei Tian, **xing Wei, **g Li, Junkai Ren, Chaohong He in Cell Death Discovery (2024)

Article

The epigenetic regulators EP300/CREBBP represent promising therapeutic targets in MLL-rearranged acute myeloid leukemia

Acute myeloid leukemia (AML) with mixed-lineage leukemia (MLL) gene rearrangements (MLL-r) is an aggressive subtype of blood cancer with dismal prognosis, underscoring the urgent need for novel therapeutic strate...

Wenqi Wu, Yanan Jiang, Donghui **ng, Yixin Zhai, Huimeng Sun… in Cell Death Discovery (2024)

Article

NCAPD3 exerts tumor-promoting effects in prostatic cancer via dual impact on miR-30a-5p by STAT3-MALAT1 and MYC

Non-SMC condensin II complex subunit D3 (NCAPD3) is a subunit of the non-structural maintenance of chromosomes condensin II complex, which involves chromosome condensation and segregation during mitosis. NCAPD...

Yi Zhang, Yingying Shao, Jia Ren, Yuanyuan Fang, Bolin Yang… in Cell Death Discovery (2024)

Article

METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging

Senile osteoporosis is mainly caused by osteoblasts attenuation, which results in reduced bone mass and disrupted bone remodeling. Numerous studies have focused on the regulatory role of m6A modification in os...

Yaobin Wang, Yi Chen, Hefang **ao, Zhongcheng Liu, Xuening Liu… in Cell Death Discovery (2024)

Article

Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells

Acute pancreatitis (AP) continues to pose a major challenge as targeted therapeutic interventions are absent. Mitochondrial dysfunction and inflammasome-dependent pyroptosis are involved in the pathogenic mech...

Wuming Liu, Yifan Ren, Tao Wang, Mengzhou Wang, Yujia Xu, Jia Zhang… in Cell Death Discovery (2024)

Article

RIPK1 inhibitor ameliorates pulmonary injury by modulating the function of neutrophils and vascular endothelial cells

Acute lung injury (ALI) is an acute and progressive hypoxic respiratory failure that could progress to acute respiratory distress syndrome (ARDS) with a high mortality rate, thus immediate medical attention an...

Tao Yang, Cai-gui **ang, **ao-han Wang, Qing-qing Li, Shu-yue Lei… in Cell Death Discovery (2024)

Article

Mitochondria-associated endoplasmic reticulum membrane (MAM): a dark horse for diabetic cardiomyopathy treatment

Diabetic cardiomyopathy (DCM), an important complication of diabetes mellitus (DM), is one of the most serious chronic heart diseases and has become a major cause of heart failure worldwide. At present, the pa...

Yong Liu, **-Ling Huo, Kaidi Ren, Shaokang Pan, Hengdao Liu… in Cell Death Discovery (2024)

Article

Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers

The limited differentiation ability of adipose-derived stem cells (ADSCs) limits their application in stem cell therapy and regenerative medicine. Here, we explore the molecular mechanism by which miR-204-5p r...

Zhimin Wang, Meiyu Bi, **aoshu Zhe, **ao Wang, Bai Dai, **aoyu Han… in Cell Death Discovery (2024)

Article

Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets

Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age, leading to continuous heart failure, even in people without a prio...

Yi Luan, **aofan Zhu, Yuxue Jiao, Hui Liu, Zhen Huang, **yan Pei… in Cell Death Discovery (2024)

Article

Increased thrombospondin-1 levels contribute to epileptic susceptibility in neonatal hyperthermia without seizures via altered synaptogenesis

Childhood febrile seizures (FS) represent one of the most common types of seizures and may lead to severe neurological damage and an increased risk of epilepsy. However, most children with fevers do not show c...

Yujie Zhai, Yao Cheng, Yi Yuan, **anfeng Meng, Yang Li, Yan Wang… in Cell Death Discovery (2024)

Article

CHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma

Currently, there is still a lack of novel and effective drug targets to improve the prognosis of hepatocellular carcinoma (HCC). Additionally, the role of CHEK2 in HCC has not been reported yet. The eQTLgen da...

Yuyan Chen, Zhengyi Zhu, **ngyu Wu, Hui Li, Wenxian Guan… in Cell Death Discovery (2024)

Article

Targeting PAK4 reverses cisplatin resistance in NSCLC by modulating ER stress

Chemoresistance poses a significant impediment to effective treatments for non-small-cell lung cancer (NSCLC). P21-activated kinase 4 (PAK4) has been implicated in NSCLC progression by invasion and migration. ...

Shixin Liu, **shan Yang, Lu Wang, **aofang Zou, Dongdong Zhang… in Cell Death Discovery (2024)

Article

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulation

Glaucoma is a highly heritable disease, and myocilin was the first identified causal and most common pathogenic gene in glaucoma. Serine-to-proline mutation at position 341 of myocilin (MYOC^S341P) is associated w...

Xue**g Yan, Shen Wu, Qian Liu, Ying Cheng, Yufei Teng, Tianmin Ren… in Cell Death Discovery (2024)

Article

Upregulation of Hsp27 via further inhibition of histone H2A ubiquitination confers protection against myocardial ischemia/reperfusion injury by promoting glycolysis and enhancing mitochondrial function

Research suggests that ischemic glycolysis improves myocardial tolerance to anoxia and low-flow ischemia. The rate of glycolysis during ischemia reflects the severity of the injury caused by ischemia and subse...

Pilong Shi, Jiawei Wu, Minghui Li, Yonggang Cao, Jiabi Wu, ** Ren… in Cell Death Discovery (2023)

Article

Correction: In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma

Li Li, Tao **ng, Yiran Chen, Weiran Xu, Bo Fan, Gaoda Ju, **g Zhao… in Cell Death Discovery (2023)

Article

A novel microtubule inhibitor promotes tumor ferroptosis by attenuating SLC7A11/GPX4 signaling

MP-HJ-1b is a novel microtubule inhibitor that we designed and reported previously. Ferroptosis is a newly identified type of nonapoptotic cell death induced by ferrous catalysis and lipid peroxidation. Here, ...

Nannan Ning, Ziqi Shang, Zhi** Liu, Zhizhou **a, Yang Li… in Cell Death Discovery (2023)

Article

STIM1 in tumor cell death: angel or devil?

Stromal interaction molecule 1 (STIM1) is involved in mediating the store-operated Ca²⁺ entry (SOCE), driving the influx of the intracellular second messenger calcium ion (Ca²⁺), which is closely associated with ...

Ran Ren, Yongsheng Li in Cell Death Discovery (2023)

Article

Decoding the metastatic potential and optimal postoperative adjuvant therapy of melanoma based on metastasis score

Metastasis is a formidable challenge in the prognosis of melanoma. Accurately predicting the metastatic potential of non-metastatic melanoma (NMM) and determining effective postoperative adjuvant treatments fo...

Kangjie Shen, Wenyu Song, Hongye Wang, Lu Wang, Yang Yang… in Cell Death Discovery (2023)

Article

KCNAB2 overexpression inhibits human non-small-cell lung cancer cell growth in vitro and in vivo

Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases. NSCLC patients often have poor prognosis demanding urgent identification of novel biomarkers and potential therapeuti...

Feng Cheng, Yu-fei Tang, Yang Cao, Shi-qing Peng, **ao-ren Zhu… in Cell Death Discovery (2023)