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  1. No Access

    Article

    Impact of Presarcopenic Dysphagia on 1-Year Mortality After Videofluoroscopic Swallowing Study in Patients with Cancer

    Sarcopenic dysphagia is the term for swallowing difficulty associated with loss of mass, strength, and physical performance, which leads to increased pharyngeal residues. Unlike sarcopenia, presarcopenia is ch...

    Toshiyuki Moriyama, Akiko Hachisuka, Yasuyuki Matsusihima, Mizuki Tokunaga in Dysphagia (2024)

  2. Article

    Open Access

    Long-term outcomes of neoadjuvant trastuzumab emtansine + pertuzumab (T-DM1 + P) and docetaxel + carboplatin + trastuzumab + pertuzumab (TCbHP) for HER2-positive primary breast cancer: results of the randomized phase 2 JBCRG20 study (Neo-peaks)

    The randomized phase 2 Neo-peaks study examined usefulness of neoadjuvant trastuzumab emtansine + pertuzumab (T-DM1 + P) following docetaxel + carboplatin + trastuzumab + pertuzumab (TCbHP) as compared with th...

    Toshimi Takano, Norikazu Masuda, Mitsuya Ito in Breast Cancer Research and Treatment (2024)

  3. Article

    Open Access

    Nonlinear association between PD-L1 expression levels and the risk of postoperative recurrence in non-small cell lung cancer

    Accurate prediction of postoperative recurrence is important for optimizing the treatment strategies for non-small cell lung cancer (NSCLC). Previous studies identified the PD-L1 expression in NSCLC as a risk ...

    Kensuke Kojima, Hironobu Samejima, Takafumi Iguchi in Scientific Reports (2024)

  4. Article

    Open Access

    Correction: The Japanese Breast Cancer Society Clinical Practice Guidelines for Breast Cancer, 2022 Edition: changes from the 2018 edition and general statements on breast cancer treatment

    Yutaka Yamamoto, Chikako Yamauchi, Tatsuya Toyama, Shigenori Nagai in Breast Cancer (2024)

  5. Article

    Open Access

    Urine oxygenation predicts COVID-19 risk

    Since February, 2023, the omicron variant has accounted for essentially all new coronavirus infections in Japan. If future infections involve mutant strains with the same level of infectivity and virulence as ...

    Eisei Noiri, Daisuke Katagiri, Yusuke Asai in Clinical and Experimental Nephrology (2024)

  6. No Access

    Article

    Circulating Exosomal MicroRNA Signature Predicts Peritoneal Metastasis in Patients with Advanced Gastric Cancer

    Despite a radical operation, about half of gastric cancer (GC) patients with advanced GC experience peritoneal metastasis (PM), and the patients with PM have a poor prognosis. However, because staging laparosc...

    Yuma Wada MD, PhD, Masaaki Nishi MD, PhD in Annals of Surgical Oncology (2024)

  7. Article

    Open Access

    A newly identified gene Ahed plays essential roles in murine haematopoiesis

    The development of haematopoiesis involves the coordinated action of numerous genes, some of which are implicated in haematological malignancies. However, the biological function of many genes remains elusive ...

    Ritsuko Nakai, Takafumi Yokota, Masahiro Tokunaga, Mikiro Takaishi in Nature Communications (2024)

  8. Article

    Open Access

    Partial cardiopulmonary bypass through left thoracotomy for coarctation repair in children

    A left thoracotomy approach is anatomically appropriate for childhood aortic coarctation; however, the pediatric femoral arteriovenous diameters are too small for cardiopulmonary bypass cannulation. We aimed t...

    Kunihiko Joo, Yoshie Ochiai, Yuma Motomatsu in Journal of Cardiothoracic Surgery (2024)

  9. No Access

    Article

    Prognostic impact of the combination of p16INK4a, p21 and Immunoscore in rectal cancer

    The association between p16INK4a and p21, a marker of cellular senescence, and the Immunoscore, an immunological prognostic indicator, in rectal cancer patients undergoing curative surgery were investigated.

    Toshihiro Nakao, Mitsuo Shimada in International Journal of Clinical Oncology (2024)

  10. Article

    Open Access

    Trastuzumab deruxtecan versus treatment of physician’s choice in previously treated Asian patients with HER2-low unresectable/metastatic breast cancer: subgroup analysis of the DESTINY-Breast04 study

    In the global phase 3 DESTINY-Breast04 study (NCT03734029), the anti-human epidermal growth factor 2 (HER2) antibody–drug conjugate trastuzumab deruxtecan (T-DXd) demonstrated a statistically significant impro...

    Toshinari Yamashita, Joo Hyuk Sohn, Eriko Tokunaga, Naoki Niikura in Breast Cancer (2024)

  11. Article

    Open Access

    Trends in Anti-Influenza Drug Prescription and Adverse Drug Reaction Reporting After the Lifting of Oseltamivir Prescribing Restrictions in Pediatric Outpatients: An Ecological Study Using the MDV Analyzer® And the Japanese Adverse Drug Event Report Database

    Abnormal behavior after oseltamivir administration has been reported in the media; in 2007, the package insert for oseltamivir phosphate was revised to restrict its administration to individuals aged over 10 y...

    Misaki Tokunaga, Daisuke Kikuchi, Aoi Noda, Sachiko Oikawa in Drugs - Real World Outcomes (2024)

  12. No Access

    Article

    Prognostic Significance of Sarcopenia and Systemic Inflammatory Markers in Biliary Tract Cancer: A Retrospective Cohort Study

    To evaluate the prognostic significance of sarcopenia and systemic inflammatory markers in patients with surgically resected biliary tract cancer (BTC).

    Masashi Utsumi, Masaru Inagaki, Koji Kitada in Journal of Gastrointestinal Cancer (2024)

  13. No Access

    Article

    High versus low chloride load in adult hyperglycemic emergencies with acute kidney injury: a multicenter retrospective cohort study

    Hyperglycemic emergencies frequently lead to acute kidney injury (AKI) and require treatment with large amount of intravenous fluids. However, the effects of chloride loading on this population have not yet be...

    Kyosuke Takahashi, Norimichi Uenishi, Masamitsu Sanui in Internal and Emergency Medicine (2024)

  14. Article

    Open Access

    Blue light irradiation inhibits the M2 polarization of the cancer-associated macrophages in colon cancer

    Recent studies have shown that blue light-emitting diode (LED) light has anti-tumor effects, suggesting the possibility of using visible light in cancer therapy. However, the effects of blue light irradiation ...

    Toshiaki Yoshimoto, Masaaki Nishi, Shohei Okikawa, Kozo Yoshikawa in BMC Cancer (2024)

  15. Article

    Open Access

    Photoinduced dynamics during electronic transfer from narrow to wide bandgap layers in one-dimensional heterostructured materials

    Electron transfer is a fundamental energy conversion process widely present in synthetic, industrial, and natural systems. Understanding the electron transfer process is important to exploit the uniqueness of ...

    Yuri Saida, Thomas Gauthier, Hiroo Suzuki, Satoshi Ohmura in Nature Communications (2024)

  16. Article

    Open Access

    Layer-Wise External Attention by Well-Localized Attention Map for Efficient Deep Anomaly Detection

    The external attention mechanism offers a promising approach to enhance image anomaly detection (Hayakawa et al., in: IMPROVE, pp. 100-–110, 2023). Nevertheless, the effectiveness of this method is contingent ...

    Keiichi Nakanishi, Ryo Shiroma, Tokihisa Hayakawa, Ryoya Katafuchi in SN Computer Science (2024)

  17. Article

    Open Access

    Dynamic movement of the Golgi unit and its glycosylation enzyme zones

    Knowledge on the distribution and dynamics of glycosylation enzymes in the Golgi is essential for better understanding this modification. Here, using a combination of CRISPR/Cas9 knockin technology and super-r...

    Akihiro Harada, Masataka Kunii, Kazuo Kurokawa, Takuya Sumi in Nature Communications (2024)

  18. Article

    Open Access

    Higher order exchange driven noncoplanar magnetic state and large anomalous Hall effects in electron doped kagome magnet Mn3Sn

    Owing to geometrical frustration in the kagome lattice, Mn3Sn displays a 120° in-plane triangular antiferromagnetic order, a manifestation of exchange interaction within the Heisenberg model. Here, we show the fo...

    Charanpreet Singh, Sk Jamaluddin, Subhadip Pradhan, Ashis K. Nandy in npj Quantum Materials (2024)

  19. No Access

    Article

    All-to-All Data Exchange Method for MANET in Congestion Environment

    Mobile Ad-hoc Network (MANET) are expected to be a means of communication for disaster victim support systems and information distribution systems at event sites where it is challenging to use existing infrast...

    Jumpei Tokunaga, Hiroyuki Ebara in The Review of Socionetwork Strategies (2024)

  20. Article

    Open Access

    Japanese tort-case dataset for rationale-supported legal judgment prediction

    This paper presents the first dataset for Japanese Legal Judgment Prediction (LJP), the Japanese Tort-case Dataset (JTD), which features two tasks: tort prediction and its rationale extraction. The rationale e...

    Hiroaki Yamada, Takenobu Tokunaga, Ryutaro Ohara in Artificial Intelligence and Law (2024)

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