64 Result(s)
within
** Lu Li
Biomedicine, general
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Article
Open AccessEstablishment and characterization of a novel multidrug-resistant pancreatic ductal adenocarcinoma cell line, PDAC-X1
Drug resistance remains a significant challenge in the treatment of pancreatic cancer. The development of drug-resistant cell lines is crucial to understanding the underlying mechanisms of resistance and devel...
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Article
Open AccessCharacterizing human postprandial metabolic response using multiway data analysis
Analysis of time-resolved postprandial metabolomics data can improve our understanding of the human metabolism by revealing similarities and differences in postprandial responses of individuals. Traditional da...
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The unique spontaneous polarization property and application of ferroelectric materials in photocatalysis
The unique spontaneous polarization property of ferroelectric material makes it to be a special catalyst in photocatalysis. The spontaneous polarization property can induce the formation of built-in electric f...
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Open AccessInhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke
Acute ischemic stroke is a common neurological disease with a significant financial burden but lacks effective drugs. Hypoxia-inducible factor (HIF) and prolyl hydroxylases (PHDs) participate in the pathophysi...
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Article
Nitric oxide and ion channels mediate l-cysteine-induced inhibition of colonic smooth muscle contraction
Previous studies have suggested that l-cysteine regulates gut motility through hydrogen sulfide. However, the mechanisms involved in the l-cysteine-induced response have not been extensively studied. This study a...
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Article
Open AccessEffects of small-dose S-ketamine on anesthesia-induced atelectasis in patients undergoing general anesthesia accessed by lung ultrasound: study protocol for a randomized, double-blinded controlled trial
Atelectasis after anesthesia induction in most patients undergoing general anesthesia may lead to postoperative pulmonary complications (PPCs) and affect postoperative outcomes. However, there is still no exis...
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Article
Open AccessEffect of transvaginal Lactobacillus supplementation on reversing lower genital tract dysbiosis and improving perinatal outcomes in PCOS patients after IVF-FET: a study protocol for a multicenter randomized controlled trial
Significant lower genital tract (LGT) dysbiosis and an associated lower rate of clinical pregnancy after in vitro fertilization–frozen embryo transfer (IVF-FET) among polycystic ovary syndrome (PCOS) patients ...
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Article
Open AccessThe secreted peptide BATSP1 promotes thermogenesis in adipocytes
Although brown adipose tissue (BAT) has historically been viewed as a major site for energy dissipation through thermogenesis, its endocrine function has been increasingly recognized. However, the circulating ...
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Article
Batch fabrication of MoS2 devices directly on growth substrates by step engineering
Monolayer molybdenum disulfide (MoS2) has emerged as one of the most promising channel materials for next-generation nanoelectronics and optoelectronics owing to its atomic thickness, dangling-bond-free flat surf...
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Article
Open AccessUsing immunovascular characteristics to predict very early recurrence and prognosis of resectable intrahepatic cholangiocarcinoma
To predict the very early recurrence (VER) of patients with intrahepatic cholangiocarcinoma (ICC) based on TLSs and MVI status, and further perform prognosis stratifications.
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Article
Open AccessA novel metabolic subtype with S100A7 high expression represents poor prognosis and immuno-suppressive tumor microenvironment in bladder cancer
Bladder cancer (BLCA) represents a highly heterogeneous disease characterized by distinct histological, molecular, and clinical features, whose tumorigenesis and progression require aberrant metabolic reprogra...
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Article
Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization
Current evidence finds that circulating exosomal lncRNA focally amplified lncRNA on chromosome 1 (FAL1) promotes the progression of hepatocellular carcinoma (HCC). However, the underlying mechanism of serum ex...
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Article
ROS inhibition increases KDM6A-mediated NOX2 transcription and promotes macrophages oxidative stress and M1 polarization
Reactive oxygen species (ROS) play an essential role in macrophage polarization. However, the adverse effects of ROS reduction by influencing epigenetics are often ignored. In this study, lipopolysaccharide (L...
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Article
In situ formed synaptic Zn@LiZn host derived from ZnO nanofiber decorated Zn foam for dendrite-free lithium metal anode
Lithium metal is regarded as the most promising anode material for next generation high energy density lithium batteries due to its high theoretical capacity and lowest potential versus standard hydrogen elect...
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Article
CSNK1D-mediated phosphorylation of HNRNPA2B1 induces miR-25-3p/miR-93-5p maturation to promote prostate cancer cell proliferation and migration through m6A-dependent manner
It has been reported that heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) is highly expressed in prostate cancer (PCa) and associated with poor prognosis of patients with PCa. Nevertheless, the speci...
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Article
Moiré-superlattice MXenes enabled ultra-stable K-ion storage in neutral electrolyte
Ti3C2 MXene is an auspicious energy storage material due to its metallic conductivity and layered assembly. However, in the real working condition of electrochemical energy storage with long cycle charging—discha...
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Article
Open AccessLncNAP1L6 activates MMP pathway by stabilizing the m6A-modified NAP1L2 to promote malignant progression in prostate cancer
Malignant progression such as bone metastasis, which is associated with pathologic fractures, pain and reduced survival frequently occurs in prostate cancer (PCa) patients at advanced stages. Accumulating evid...
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Article
Bead-like cobalt-nitrogen co-doped carbon nanocage/carbon nanofiber composite: a high-performance oxygen reduction electrocatalyst for zinc-air batteries
Proper regulation of metal-nitrogen carbon (M-N-C) materials derived from zeolitic imidazolate frameworks (ZIFs) is essential to enhance the oxygen reduction reaction (ORR) performance. However, most of the re...
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Article
Open AccessPhase I study of LZM005 in patients with HER2-positive metastatic breast cancer
The prognosis of human epidermal growth factor receptor 2 (HER2) positive metastatic breast cancer (MBC) remained unsatisfactory currently, more anti-HER2 agents are needed. Here we report a phase I study that...
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Article
Open AccessRif1 interacts with non-canonical polycomb repressive complex PRC1.6 to regulate mouse embryonic stem cells fate potential
Mouse embryonic stem cells (mESCs) cycle in and out of a transient 2-cell (2C)-like totipotent state, driven by a complex genetic circuit involves both the coding and repetitive sections of the genome. While a...
