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Open AccessThe maternal drug exposure birth cohort (DEBC) in China
Drug exposure during pregnancy lacks global fetal safety data. The maternal drug exposure birth cohort (DEBC) study, a prospective longitudinal investigation, aims to explore the correlation of maternal drug e...
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Article
Open AccessLanthanide-regulating Ru-O covalency optimizes acidic oxygen evolution electrocatalysis
Precisely modulating the Ru-O covalency in RuOx for enhanced stability in proton exchange membrane water electrolysis is highly desired. However, transition metals with d-valence electrons, which were doped into ...
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Article
Open AccessAssociation between Life’s Essential 8 and cataract among US adults
Currently, a comprehensive assessment of the relationship between ideal cardiovascular health (CVH) indicators and cataract risk is lacking. Life’s Essential 8 (LE8) is the latest concept proposed by the Ameri...
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Open AccessAn individualized protein-based prognostic model to stratify pediatric patients with papillary thyroid carcinoma
Pediatric papillary thyroid carcinomas (PPTCs) exhibit high inter-tumor heterogeneity and currently lack widely adopted recurrence risk stratification criteria. Hence, we propose a machine learning-based objec...
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Article
Open AccessA novel multidrug-resistant cell line from a Chinese patient with pancreatic ductal adenocarcinoma
Chemotherapy resistance poses clinical challenges in pancreatic cancer treatment. Develo** cell lines resistant to chemotherapy is crucial for investigating drug resistance mechanisms and identifying alterna...
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Open AccessAn IoT-based low-cost architecture for smart libraries using SDN
In the evolving landscape of smart libraries, this research pioneers an IoT-based low-cost architecture utilizing Software-Defined Networking (SDN). The increasing demand for more efficient and economical solu...
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Article
Open AccessNADPH oxidase 2 mediates cardiac sympathetic denervation and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced cardiomyopathy
Doxorubicin has been used extensively as a potent anticancer agent, but its clinical use is limited by its cardiotoxicity. However, the underlying mechanisms remain to be fully elucidated. In this study, we te...
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Open AccessInfluence of thermal maturity on carbazole distributions in coal source rocks during compaction pyrolysis experiments
Carbazole compounds are widely used in determining the direction of petroleum migration, but the effect of thermal maturity on carbazoles is still ambiguity. In this paper, using compaction pyrolysis simulatio...
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Article
Open AccessElectron/infrared-phonon coupling in ABC trilayer graphene
Stacking order plays a crucial role in determining the crystal symmetry and has significant impacts on electronic, optical, magnetic, and topological properties. Electron-phonon coupling, which is central to a...
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Open AccessEpitaxy of wafer-scale single-crystal MoS2 monolayer via buffer layer control
Monolayer molybdenum disulfide (MoS2), an emergent two-dimensional (2D) semiconductor, holds great promise for transcending the fundamental limits of silicon electronics and continue the downscaling of field-effe...
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Article
Open AccessChromosome-level genome assembly of the Asian spongy moths Lymantria dispar asiatica
The Asian spongy moth, Lymantria dispar asiatica, is one of the most devastating forestry defoliators. The absence of a high-quality genome limited the understanding of its adaptive evolution. Here, we conducted ...
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Open AccessComparison of the diagnostic efficacy of mathematical models in distinguishing ultrasound imaging of breast nodules
This study compared the diagnostic efficiency of benign and malignant breast nodules using ultrasonographic characteristics coupled with several machine-learning models, including logistic regression (Logistic...
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Open AccessSingle-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer
Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and immunological characteristics that remain unclear. Here, we perform transcriptomic analysis for 111,038 single cells from tumor ti...
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Open AccessComparison of the Jcerity endoscoper airway and the endotracheal tube in endoscopic esophageal variceal ligation: a prospective randomized controlled trial
Various airway techniques have been used in endoscopic esophageal variceal ligation (EVL). In this respect, Jcerity endoscoper airway (JEA) is a novel laryngeal mask airway that is designed for use in gastroin...
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Article
Open AccessScreening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA’s role in regulating miR-999
MicroRNAs (miRNA) load onto AGO proteins to target mRNAs for translational repression or degradation. However, miRNA degradation can be triggered when extensively base-paired with target RNAs, which induces co...
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Open AccessBeta variant COVID-19 protein booster vaccine elicits durable cross-neutralization against SARS-CoV-2 variants in non-human primates
The rapid spread of the SARS-CoV-2 Omicron subvariants, despite the implementation of booster vaccination, has raised questions about the durability of protection conferred by current vaccines. Vaccine booster...
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Open AccessFTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke
Vascular repair is considered a key restorative measure to improve long-term outcomes after ischemic stroke. N6-methyladenosine (m6A), the most prevalent internal modification in eukaryotic mRNAs, functionally me...
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Article
Open AccessSpatially resolved proteomics via tissue expansion
Spatially resolved proteomics is an emerging approach for map** proteome heterogeneity of biological samples, however, it remains technically challenging due to the complexity of the tissue microsampling tec...
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Open AccessEfficacy of three different budesonide treatments in Chinese preschool children with recurrent wheezing
To explore and compare the clinical control of three atomized inhalation budesonide (BUD) regimens for Chinese preschool children with recurrent wheezing using Test for Respiratory and Asthma Control (TRACK) s...
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Open AccessPublisher Correction: Clinical characteristics and immune profile alterations in vaccinated individuals with breakthrough Delta SARS-CoV-2 infections