89 Result(s)

Article

Establishment and characterization of a novel multidrug-resistant pancreatic ductal adenocarcinoma cell line, PDAC-X1

Drug resistance remains a significant challenge in the treatment of pancreatic cancer. The development of drug-resistant cell lines is crucial to understanding the underlying mechanisms of resistance and devel...

Cheng Yu, Yuanhui Su, **n Miao, Changpeng Chai, Huan Tang, Lu Li, Jianfeng Yi… in BMC Cancer (2024)

Article

Molecular characterization and induced changes of histone acetyltransferases in the tick Haemaphysalis longicornis in response to cold stress

Epigenetic modifications of histones play important roles in the response of eukaryotic organisms to environmental stress. However, many histone acetyltransferases (HATs), which are responsible for histone ace...

Tingwei Pei, Miao Zhang, Ziwen Gao, Lu Li, Ziyan Bing, Jianglei Meng… in Parasites & Vectors (2024)

Article

Repetitive temporal interference stimulation improves jump performance but not the postural stability in young healthy males: a randomized controlled trial

Temporal interference (TI) stimulation, an innovative non-invasive brain stimulation technique, has the potential to activate neurons in deep brain regions. The objective of this study was to evaluate the effe...

Suwang Zheng, Tianli Fu, **long Yan… in Journal of NeuroEngineering and Rehabilita… (2024)

Article

Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke

Acute ischemic stroke is a common neurological disease with a significant financial burden but lacks effective drugs. Hypoxia-inducible factor (HIF) and prolyl hydroxylases (PHDs) participate in the pathophysi...

Jian **e, Yuan Zhang, Bin Li, Wen **, Yu Wang, Lu Li… in Journal of Translational Medicine (2024)

Article

Prevalence and progression of pneumonia in immunocompetent adults with varicella

Pneumonia is the most common complication of varicella infections. Although previous studies have tended to focus mainly on immunocompromised patients, varicella pneumonia can also occur in healthy adults. The...

Ran Cheng, Fei Lin, Zhonghua Deng, **g** Liang, **aoguang Li, Ming Lu… in Virology Journal (2024)

Article

Integrative Analysis of DNA Methylation and Gene Expression Data Identifies Potential Biomarkers and Functional Epigenetic Modules for SARS-CoV-2

To integrate gene expression and DNA methylation data and find the potential role of DNA methylation in the invasion and replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We first co...

Lu Li, Lingli Hu, Xueli Qiao, Ruo Mo, Guangya Liu, Lingyan Hu in Biochemical Genetics (2023)

Article

Using immunovascular characteristics to predict very early recurrence and prognosis of resectable intrahepatic cholangiocarcinoma

To predict the very early recurrence (VER) of patients with intrahepatic cholangiocarcinoma (ICC) based on TLSs and MVI status, and further perform prognosis stratifications.

Ying Xu, Zhuo Li, Yanzhao Zhou, Yi Yang, **gzhong Ouyang, Lu Li, Zhen Huang… in BMC Cancer (2023)

Article

Correction: Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression

Ying Liu, Yinghua Niu, Lu Li, Khalid A. Timani, Victor L. He… in Journal of NeuroVirology (2023)

Article

A novel metabolic subtype with S100A7 high expression represents poor prognosis and immuno-suppressive tumor microenvironment in bladder cancer

Bladder cancer (BLCA) represents a highly heterogeneous disease characterized by distinct histological, molecular, and clinical features, whose tumorigenesis and progression require aberrant metabolic reprogra...

Yun Cai, Yifei Cheng, Ziyu Wang, Lu Li, Zhengtao Qian, Wei **a, Weiwei Yu in BMC Cancer (2023)

Article

Initial analysis of the synergy of programmed cell death-1 (PD-1) inhibitor and concurrent chemoradiotherapy treatment for recurrent/metastatic head and neck squamous cell carcinoma patients

Programmed cell death-1 (PD-1) inhibitor was proven to be useful for the recurrent/metastatic head and neck squamous carcinoma (R/M HNSCC) patients. Though both PD-1 inhibitor alone and combination with chemot...

Lu Li, Lu Chen, Lu Yan, Yueqian Guo, Fang Li, Ming Fan, Mei Lan… in Radiation Oncology (2023)

Article

Psychological capital and alienation among patients with COVID-19 infection: the mediating role of social support

COVID-19 infection continues all over the world, causing serious physical and psychological impacts to patients. Patients with COVID-19 infection suffer from various negative emotional experiences such as anxi...

Chao Wu, Chun-yan He, Jia-ran Yan, Hong-li Zhang, Lu Li, Ci Tian… in Virology Journal (2023)

Article

Effects of non-invasive brain stimulation on motor function after spinal cord injury: a systematic review and meta-analysis

In recent years, non-invasive brain stimulation (NIBS) has been used for motor function recovery. However, the effects of NIBS in populations with spinal cord injury (SCI) remain unclear. This study aims to co...

Jian-Min Chen, **ao-Lu Li, Qin-He Pan… in Journal of NeuroEngineering and Rehabilita… (2023)

Article

LncNAP1L6 activates MMP pathway by stabilizing the m6A-modified NAP1L2 to promote malignant progression in prostate cancer

Malignant progression such as bone metastasis, which is associated with pathologic fractures, pain and reduced survival frequently occurs in prostate cancer (PCa) patients at advanced stages. Accumulating evid...

Yuxiao Zheng, Feng Qi, Lu Li, Bin Yu, Yifei Cheng, Minghui Ge… in Cancer Gene Therapy (2023)

Article

Phase I study of LZM005 in patients with HER2-positive metastatic breast cancer

The prognosis of human epidermal growth factor receptor 2 (HER2) positive metastatic breast cancer (MBC) remained unsatisfactory currently, more anti-HER2 agents are needed. Here we report a phase I study that...

Cong Xue, Haifeng Li, Herui Yao, Ying Lin, **n An, Meiting Chen… in npj Breast Cancer (2022)

Article

CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment

Anaplastic thyroid carcinoma (ATC) is an extremely malignant type of endocrine cancer frequently accompanied by extrathyroidal extension or metastasis through mechanisms that remain elusive. We screened for th...

Zongfu Pan, Tong Xu, Lisha Bao, ** Hu, Tiefeng **, **ming Chen… in Molecular Cancer (2022)

Article

Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia

Acute myeloid leukemia (AML) is a myeloid neoplasm makes up 7.6% of hematopoietic malignancies. Super-enhancers (SEs) represent a special group of enhancers, which have been reported in multiple cell types. In...

Fang Fang, Jun Lu, Xu Sang, Yan-Fang Tao… in Journal of Experimental & Clinical Cancer … (2022)