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Article
The association between dietary selenium intake and Hashimoto’s thyroiditis among US adults: National Health and Nutrition Examination Survey (NHANES), 2007–2012
Selenium has been shown to influence the pathological processes and physiological functions of thyroid. Although growing evidence has shown that selenium can improve the treatment of Hashimoto’s thyroiditis (H...
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Article
Open AccessTargeting IL-2: an unexpected effect in treating immunological diseases
Regulatory T cells (Treg) play a crucial role in maintaining immune homeostasis since Treg dysfunction in both animals and humans is associated with multi-organ autoimmune and inflammatory disease. While IL-2 ...
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Article
Open AccessSRGN-TGFβ2 regulatory loop confers invasion and metastasis in triple-negative breast cancer
Patients with triple-negative breast cancers (TNBC) are at a high risk for a recurrent or metastatic disease, and the molecular mechanisms associated with this risk are unclear. Proteoglycan serglycin (SRGN) p...
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Article
Cip2a promotes cell cycle progression in triple-negative breast cancer cells by regulating the expression and nuclear export of p27Kip1
Triple-negative breast cancer (TNBC) is very aggressive and currently has no specific therapeutic targets; as a consequence, TNBC exhibits poor clinical outcome. In this study, we showed that cancerous inhibit...
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Article
Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation
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Article
TRM6/61 connects PKCα with translational control through tRNAiMet stabilization: impact on tumorigenesis
Accumulating evidence suggests that changes of the protein synthesis machinery alter translation of specific mRNAs and participate in malignant transformation. Here we show that protein kinase C α (PKCα) inter...
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Article
High expression of EDAG and its significance in AML
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Article
Gene transfer of pro-IL-18 and IL-1β converting enzyme cDNA induces potent antitumor effects in L1210 cells
We report in a murine model of acute lymphoid leukemia L1210 the potent antitumor efficiency of a combinatorial delivery of pro-IL-18 gene modified L1210 (Lp18) and IL-1β converting enzyme (ICE) gene modified L12...