206 Result(s)

Article

The Effect of Neonatal Administration of Sex Hormones on Ribonucleic Acid Metabolism in the Liver of Male and Female Rats

Fifteen minutes after the intraperitoneal injection of ³²P labelled phosphate, normal adult male rats show a higher incorporation of isotope into their liver nuclear RNA than do females. A single injection of tes...

Yee-Chu Toh in British Journal of Cancer (1971)

Article

Repair of O⁶-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B₁

Pretreatment of rats by the repeated administration of certain alkylating carcinogens has been shown to stimulate the removal of O6-alkylguanine from hepatic DNA. Prolonged feeding with the aromatic amide 2-ac...

Y H Chu, A W Craig, P J O'Connor in British Journal of Cancer (1981)

Article

Nutrient intakes in relation to cancer incidence in Hawaii

A representative sample of 4657 adults greater than or equal to 45 years of age from the 5 main ethnic groups in Hawaii (Caucasians, Japanese, Chinese, Filipinos and Hawaiians) were interviewed during 1977-197...

L N Kolonel, J H Hankin, J Lee, S Y Chu, A M Nomura, M W Hinds in British Journal of Cancer (1981)

Article

The association of condylomata acuminata and squamous carcinoma of the vulva

J R Daling, J Chu, N S Weiss, L Emel, H K Tamini in British Journal of Cancer (1984)

Article

Multiple primary tumours in women with vulvar neoplasms: a case-control study

We sought to determine whether women with in situ or invasive squamous cell vulvar cancer were more likely than other women to have had a previous or concurrent tumour at other anogenital sites. One hundred an...

KJ Sherman, JR Daling, J Chu, B McKnight, NS Weiss in British Journal of Cancer (1988)

Article

Flavone acetic acid (FAA) with recombinant interleukin-2 (rIL-2) in advanced malignant melanoma. III: Cytokine studies

Twelve patients undergoing IL-2 and flavone acetic acid (FAA) combination immunotherapy for advanced melanoma were studied throughout treatment for the induction of measurable levels of bioactive TNF, GM-CSF a...

C Haworth, SM O'Reilly, E Chu, GJS Rustin, M Feldmann in British Journal of Cancer (1993)

Article

Acidic pH enhances the invasive behavior of human melanoma cells

As a consequence of poor perfusion and elevated acid production, the extracellular pH (pH^ex) of tumors is generally acidic. Despite this, most in vitro experiments are still performed at the relatively alkaline p...

Raul Martínez-Zaguilán, Elisabeth A. Seftor… in Clinical & Experimental Metastasis (1996)

Article

Role of intermediate filaments in migration, invasion and metastasis

The expression of intermediate filament proteins is remarkably tissue-specific which suggests that the intermediate filament (IF) type(s) present in cells is somehow related to their biological function. Howev...

Mary J. C. Hendrix, Elisabeth A. Seftor, Yi-Wen Chu… in Cancer and Metastasis Reviews (1996)

Article

All-trans retinoic acid decreases susceptibility of a gastric cancer cell line to lymphokine-activated killer cytotoxicity

All-trans retinoic acid (RA) was previously shown to regulate the growth of gastric cancer cells derived from the cell line SC-M1. This study was designed to investigate the effect of RA on the sensitivity of ...

TY Chao, SY Jiang, RY Shyu, MY Yeh, TM Chu in British Journal of Cancer (1997)

Article

Proteolysis of extracellular matrix by invadopodiafacilitates human breast cancer cell invasion and ismediated by matrix metalloproteinases

Breast cancer cell lines vary in invasive behavior and one highly invasive cell line (MDA-MB-231)proteolytically degrades extracellular matrix with invadopodia (Thompson et al. 1992, J Cell Physiol, 150,534-44...

Thomas Kelly, Yan Yan, Rebecca L Osborne… in Clinical & Experimental Metastasis (1998)

Article

Differential diagnostic significance of the paucity of HLA- I antigens on metastatic breast carcinoma cells in effusions

Distinction between benign reactive mesothelial cells and metastatic breast adenocarcinoma cells in effusions from patients with a known prior history of breast cancer is not the easiest task in diagnostic pat...

Edina Magyarosy, W John Martin, Elizabeth W Chu… in Pathology & Oncology Research (1999)

Article

Small cell carcinoma of the gallbladder: Report of two cases

Two Taiwanese patients with gallbladder small cell carcinoma are reported. One is a 79 year-old male, the other, a 86 year-old female. They both presented with the symptom/signs of acute cholecystitis and unde...

Shih-Sung Chuang, Ching-Nan Lin, Chien-Hui Chu… in Pathology & Oncology Research (1999)

Article

Comparison between `in vivo' and `in vitro' methods for evaluating tumor angiogenesis using cervical carcinoma as a model

The role of angiogenesis in tumorigenesis is widely accepted. Therefore, it is mandatory to develop a clinically useful method for assessing tumor angiogenesis. This study was designed to compare the `in vivo' an...

Wen-Fang Cheng, Chien-Nan Lee, Chi-An Chen, Jan-Show Chu, Cheng-Che S. Kung… in Angiogenesis (1999)

Article

Prospects for Targeting Protein Kinase C Isozymes in the Therapy of Drug-resistant Cancer – An Evolving Story

The seminal discovery in 1988 that selective protein kinase C (PKC) activators induce multidrug resistance (MDR) in human cancer cells spawned several years of intensive investigations; these studies were prim...

Catherine A. O'Brian, Nancy E. Ward, Jubilee R. Stewart… in Cancer and Metastasis Reviews (2001)

Article

Lineage-specific Mechanism of Drug and Radiation Resistance in Melanoma Mediated by Tyrosinase-related Protein 2

A major obstacle in the clinical management of malignant melanoma is its intrinsic resistance to chemotherapy and radiation therapy. Consequently, most patients with melanoma often do not respond to convention...

Brian J. Pak, Wendy Chu, Shi Jiang Lu, Robert S. Kerbel… in Cancer and Metastasis Reviews (2001)

Article

Translational Regulation as a Novel Mechanism for the Development of Cellular Drug Resistance

Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for ...

John C. Schmitz, Jun Liu, **ukun Lin, Tian-min Chen… in Cancer and Metastasis Reviews (2001)

Article

The greater impact of menopause on ER– than ER+ breast cancer incidence: a possible explanation (United States)

Objective: Analysis of 3359 Danish breast cancer cases indicated that menopause exerted a greater protective effect on estrogen- receptor negative (ER–) breast cancer than on estrogen- receptor positive (ER+) br...

Robert E. Tarone, Kenneth C. Chu in Cancer Causes & Control (2002)