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Computational Modeling and Simulation of the Fibrotic Human Atria
Patient-specific modeling of atrial electrical activity enables the execution of simulations that can provide mechanistic insights and provide novel...
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EEG/fNIRS
Electroencephalogram (EEG) and the functional near-infrared spectroscopy (fNIRS) are non-invasive methods to investigate the brain activity in real...
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Targeted Analysis of Glycerophospholipids and Mono-, Di-, or Tri-Acylglycerides in Liver Cancer
The metabolic rearrangements of hepatic metabolism associated with liver cancer are still incompletely understood. There is an ongoing need to...
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Kinetic Modeling of Hepatic Metabolism and Simulation of Treatment Effects
Mathematical modeling is a promising strategy to fill the experimentally unapproachable knowledge gaps about the relative contribution of various...
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Diethylnitrosamine-Induced Liver Tumorigenesis in Mice Under High-Hat High-Sucrose Diet: Stepwise High-Resolution Ultrasound Imaging and Histopathological Correlations
The hepatotoxic N-nitroso compound diethylnitrosamine (DEN) administered intraperitoneally (i.p.) induces liver neoplasms in rodents that...
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Protocols for Myosin and Actin-Myosin Assays Using Rapid, Stopped-Flow Kinetics
Fast transient kinetics using stopped-flow fluorimetry is now a powerful method for defining the ATPaseATPase cycle of myosinMyosins and its...
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Methods for the Assessment of Multisensory Processing: Behavioral and Neuropsychological Approaches
Since birth, we learn about the perceptual and social world through our senses. Learning to appropriately bind multisensory information is key to...
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Psychophysiology of Sleep
Sleep is a complex behavior, neurophysiological, psychological, and neurochemical phenomenon, which shows striking phylogenetic and ontogenetic...
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The GENTIL Method for Isolation of Human Adult Cardiomyocytes from Cryopreserved Tissue for Proteomic Analyses
Heart failure is a serious clinical and economic health care problem, and its clinical progression is linked to pathological cardiac remodeling. Due...
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Biomarker Identification in Liver Cancers Using Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) Imaging: An Approach for Spatially Resolved Metabolomics
Liver cancers are characterized by interindividual and intratumoral heterogeneity, which makes early diagnosis and the development of therapies...
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Diethylnitrosamine Induction of Hepatocarcinogenesis in Mice
Diethylnitrosamine (DEN) is a chemical hepatocarcinogenic agent that triggers a large array of oncogenic mutations after a single injection....
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Echocardiography to Assess Cardiac Structure and Function in Genetic Cardiomyopathies
Rodents are the most common experimental models used in cardiovascular research including studies of genetic cardiomyopathies. Genetic...
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Measuring the Contractile Kinetics of Isolated Myofibrils from Human-Induced Pluripotent Stem Cell Derived Cardiomyocyte (hiPSC-CM) Models of Cardiomyopathy
Isolated myofibrils provide biomechanical data at the contractile organelle level that are independent of cellular calcium handling and signaling...
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Flow Cytometry Assessment of Lymphocyte Populations Infiltrating Liver Tumors
Tissue-resident and recruited immune cells are essential mediators of natural and therapy-induced immunosurveillance of liver neoplasia. This idea...
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qEEG Methods to Probe Abnormal Brain Rhythms Related to Quiet Vigilance in Patients with Dementia Due to Alzheimer’s, Parkinson’s, and Lewy Body Diseases
Here, we discuss relevant literature findings on abnormal resting-state scalp-recorded electroencephalographic (rsEEG) rhythms in old patients with...
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Hydrodynamic Transfection of Hepatocytes for the Study of Hepatocellular Carcinogenesis
Hydrodynamic tail vein injection (HTVi), also called hydrodynamic gene transfer (HGT), is attracting increasing interest for modeling hepatic...
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Computational Modeling of Cardiac Electrophysiology
Mathematical modeling and simulation are well-established and powerful tools to integrate experimental data of individual components of cardiac...
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Pain-Related Evoked Potentials
Laser-evoked brain potentials (LEPs) are brain responses elicited by the brief activation of heat-sensitive skin nociceptors and their spinothalamic...
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Oncogene-Driven Induction of Orthotopic Cholangiocarcinoma in Mice
Cholangiocarcinoma (CCA) is a malignancy affecting the epithelial cells that line the bile ducts. This cancer shows a poor prognosis and current...
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A Mouse Model of Hepatocellular Carcinoma Induced by Streptozotocin and High-Fat Diet
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the second most common cause of cancer-related death. HCC is associated to...