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Protocol
Generation of Human iPSC-Derived Retinal Organoids for Assessment of AAV-Mediated Gene Delivery
Human retinal organoids derived from induced pluripotent stem cells (iPSCs) serve as a promising preclinical model for testing the safety and efficacy of viral gene therapy. Retinal organoids recapitulate the ...
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Protocol
Skin Biopsy and Patient-Specific Stem Cell Lines
The generation of patient-specific induced pluripotent stem (iPS) cells permits the development of next-generation patient-specific systems biology models reflecting personalized genomics profiles to better un...
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Protocol
Statistical Models for Genetic Map** in Polyploids: Challenges and Opportunities
Statistical methods for genetic map** have well been developed for diploid species but are lagging in the more complex polyploids. The genetic map** of polyploids, where genome number is higher than two, i...
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Protocol
Functional Map** of Developmental Processes: Theory, Applications, and Prospects
Functional map** is a statistical tool for map** quantitative trait loci (QTLs) that control the developmental pattern and process of a complex trait. Functional map** has two significant advantages beyo...
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Protocol
Systems Biology Approach to Imaging of Neural Stem Cells
Over the past decade, the advances in human brain magnetic resonance imaging (MRI) have significantly improved our ability to gain insightful information about the structure and function of the brain. One of t...
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Protocol
Computing Genetic Imprinting Expressed by Haplotypes
Different expression of maternally and paternally inherited alleles at certain genes is called genetic imprinting. Despite its great importance in trait formation, development, and evolution, it remains unclea...
