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    Applications of Array-CGH for Lung Cancer

    This chapter summarizes the current knowledge on gene copy number changes found in lung tumors, and their application in the diagnosis, prognostication, and prediction of response to chemotherapy. Examples of ...

    Kenneth J. Craddock, Wan L. Lam, Ming-Sound Tsao in Array Comparative Genomic Hybridization (2013)

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    Copy Number Variations in the Human Genome and Strategies for Analysis

    The structure and sequence of the genome is immensely variable in the human population. Segmental copy number variants (CNVs) contribute to the extensive phenotypic diversity among humans and have been shown t...

    Emily A. Vucic, Kelsie L. Thu, Ariane C. Williams, Wan L. Lam… in Genetic Variation (2010)

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    Comparative Genomic Hybridization on BAC Arrays

    Alterations in genomic DNA are a key feature of many constitutional disorders and cancer. The discovery of the underlying regions of gene dosage has thus been essential in dissecting complex disease phenotypes...

    Bradley P. Coe, William W. Lockwood… in Microarray Analysis of the Physical Genome (2009)

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    Methylation Analysis by DNA Immunoprecipitation (MeDIP)

    Alteration in epigenetic regulation of gene expression is a common event in human cancer and developmental disease. CpG island hypermethylation and consequent gene silencing is observed for many genes involved...

    Emily A. Vucic, Ian M. Wilson… in Microarray Analysis of the Physical Genome (2009)