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  1. No Access

    Protocol

    Delivery of Herpes Simplex Virus-Based Vectors to the Nervous System

    Gene transfer to the nervous system is an attractive option to treat a wide variety of neurological insults (1–3). The expression of trophic factor and/or antiapoptotic genes may be beneficial in halting the slow...

    James R. Goss, Atsushi Natsume, Darren Wolfe… in Gene Delivery to Mammalian Cells (2004)

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    Protocol

    Gene Transfer to Glial Tumors Using Herpes Simplex Virus

    Glial tumors occur as intraaxial masses in the brain and are uniformly fatal due to lack of effective therapy. Resection combined with radiation and chemotherapy fails to eradicate malignant cells infiltrating...

    Ajay Niranjan, Darren Wolfe, Wendy Fellows… in Gene Delivery to Mammalian Cells (2004)

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    Protocol

    Delivery of Herpes Simplex Virus-Based Vectors to Stem Cells

    In contrast to traditional drugs that generally act by altering existing gene product function, gene therapy aims to target the root cause of the disease by altering the genetic makeup of the cell to treat the...

    Darren Wolfe, James B. Wechuck, David M. Krisky… in Gene Delivery to Mammalian Cells (2004)

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    Protocol

    Delivery Using Herpes Simplex Virus

    The human herpesviruses represent excellent candidate viruses for several types of gene vector applications. As a class, they are large DNA viruses with the potential to accommodate large or multiple transgene...

    William F. Goins, Darren Wolfe, David M. Krisky… in Gene Delivery to Mammalian Cells (2004)