-
Chapter and Conference Paper
Tissue distribution and possible function of the subunits of the L-type calcium channels
L-type calcium channels are present in many tissues and are the major pathway for voltage activated calcium entry in heart and smooth muscle and are essential for EC-coupling in skeletal muscle. The transverse...
-
Chapter and Conference Paper
The Structure of the Skeletal and Nonskeletal Muscle Calcium Channel
A number of fundamental biological processes such as mobility, secretion, and neurotransmission are regulated by a change in the cytosolic calcium concentration. The cytosolic calcium concentration is raised f...
-
Chapter and Conference Paper
Site-Specific Phosphorylation of the Skeletal Muscle Receptor for Calcium-Channel Blockers by cAMP-Dependent Protein Kinase
Voltage-operated calcium channels are important factors in excitation-contraction coupling of cardiac and smooth muscle. The cardiac L-type calcium channel was the first channel known to be modified by hormone...
-
Chapter and Conference Paper
Reconstitution of Solubilized and Purified Dihydropyridine Receptor from Skeletal Muscle Microsomes as Two Single Calcium Channel Conductances with Different Functional Properties
Calcium entry through voltage-sensitive calcium channels (VSCC) is a vital link between membrane depolarization and cellular function (Hille 1984). In many excitable cells, the entry of Ca2+ ions can be inhibi...
-
Chapter and Conference Paper
Biochemistry and Physiology of Cardiac Calcium Channels
The voltage-dependent slow calcium channel allows the passive movement of calcium across the plasma membrane of a variety of excitable cells and regulates thereby directly or indirectly the cytosolic calcium c...