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  1. No Access

    Chapter and Conference Paper

    Der Arylhydrocarbon Rezeptor als neue Zielscheibe zur Behandlung des Pankreaskarzinoms

    The arylhydrocarbon receptor (AhR) was initially identified as a member of the adaptive metabolic and toxic response pathway to polycyclic aromatic hydrocarbons and to halogenated dibenzo-p-dioxins and dibenzo...

    Dr. med. J. Kleeff, H. Friess, A. Koliopanos, S. Safe… in Chirurgisches Forum 2002 (2002)

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    Chapter and Conference Paper

    Cellular and Molecular Biology of Aryl Hydrocarbon (Ah) Receptor — Mediated Gene Expression

    2,3,7,8- Tetr achlorodibenzo-p-dioxin (TCDD) and related compounds elicit diverse toxic and biochemical responses in laboratory animals and mammalian cells in culture. TCDD induces CYP1A1 gene expression and resu...

    S. Safe, V. Krishnan in Toxicology in Transition (1995)

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    Chapter and Conference Paper

    PCDDs and PCDFs: Sources and Environmental Impact

    Polychlorinated dibenzo-p-dioxins (PCDDs or polyCDDs) and polychlorinated dibenzofurans (PCDFs or polyCDFs) are members of the family of halogenated aromatic chemicals which includes the polychlorinated biphenyls...

    S. Safe, O. Hutzinger in Polychlorinated Dibenzo-p-dioxins and -fur… (1990)

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    Chapter and Conference Paper

    Polychlorinated Biphenyls: Environmental Occurrence and Analysis

    Polychlorinated biphenyls (PCBs) are complex mixtures which have been identified in every component of the global ecosystem. This chapter discusses the distribution of PCBs in the environment and points out re...

    S. Safe, L. Safe, M. Mullin in Polychlorinated Biphenyls (PCBs): Mammalia… (1987)

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    Chapter and Conference Paper

    Mammalian Biologic and Toxic Effects of PCBs

    This review outlines the mammalian toxicology of PCBs and several classes of related halogenated aromatic hydrocarbons that are persistent environmental contaminants. PCBs comprise 209 chlorinated derivatives ...

    A. Parkinson, S. Safe in Polychlorinated Biphenyls (PCBs): Mammalia… (1987)

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    Chapter and Conference Paper

    PCBs and Human Health

    Humans have been exposed to polychlorinated biphenyl (PCB) mixtures via 3 major pathways. Several thousand workers engaged in the manufacture and application of PCBs have been exposed to relatively high levels...

    S. Safe in Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology (1987)