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Chapter and Conference Paper
Non-fucosylated Therapeutic Antibodies: The Next Generation of Therapeutic Antibodies
Therapeutic antibody IgG1 has two N-linked oligosaccharide chains bound to the Fc region. The oligosaccharides are of the complex biantennary type, composed of a trimannosyl core structure with the presence or ab...
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Chapter and Conference Paper
Thermodynamic and kinetic effects of human IgG1 defucosylation on IgG1-FcγRIIIa interaction
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Chapter and Conference Paper
Generation of an industrially ideal host cell line for producing completely-defucosylated antibody with enhanced antibody-dependent cellular cytotoxicity (ADCC)