30 Result(s)
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Chapter and Conference Paper
Renoprotektive Effekte der Zelltherapie mit Progenitorzellen beim renalen Ischämie-Reperfusionsschaden: Die Notwendigkeit der Dekompressionstherapie
Purpose: Cell therapy represents a promising therapeutic approach in kidney transplantation. This study examines the precise potentials and limits of cell therapy in renal ischemia-reperf...
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Chapter and Conference Paper
Überexpression des Regenerationsfaktors Augmenter of Liver Regeneration (ALR) in humanen Gewebeproben von Fettlebern
Neoadjuvant therapy in the treatment of liver metastases often causes fatty degeneration of the liver. So far it is unclear if liver resections in patients with a fatty liver lower the ability for regeneration...
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Chapter and Conference Paper
Sox9-assozierte Überexpression des IFIT3 Gens unterstützt Pankreastumorprogression durch Aktivierung »Pseudoentzündlicher« Signaltransduktionwege
Inflammation plays an important role in tumour initiation and progression. Here we report the role of the transcription factor Sox9 for regulation of IFIT3, an inflammation-related and tumour-promoting protein...
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Chapter and Conference Paper
Der leberspezifische Wachstumsfaktor Augmenter of liver regeneration wirkt anti-inflammatorisch über STAT3/SOCS3 Inhibition in humanen Hepatozyten
Liver withholds the unique capacity to regenerate completely after 70 % resection. For restoring liver mass, an interplay between growth factors and cytokines is involved. Augmenter of liver regeneration (ALR)...
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Chapter and Conference Paper
Prädiktive Biomarker für chemotherapeutische und molekulare Therapiestrategien beim primären kolorektalen Karzinom und resektablen Lebermetastasen
To date, there are many options to treat colorectal cancers including chemotherapeutic and antibody strategies. However, there are no stratification available to identify the best treatment for the individual ...
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Chapter and Conference Paper
Targeted stem cell based RANTES/TK suicide gene-therapy in a murine pancreatic cancer tumour model
Introduction: The influence of tumour associated stromal cells on tumour growth and on the potential to metastasize is already issue of current research [1,2,3]. In preclinical studies of a breas...
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Chapter and Conference Paper
The hepatotrophic growth factor Augmenter of liver regeneration (ALR) is protective against metabolic damage via the PI3K/AKT pathway
The liver is a highly metabolic organ with a great potential of regeneration. Beside mitogenic signals via hepatotrophic growth factors like EGF (epidermal growth factor), HGF (hepatocyte growth factor) and AL...
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Chapter and Conference Paper
Tumor stem cell targeted therapy with mTOR inhibitor RAD001 and hedgehog signalling inhibitor Cyclopamine reverts chemoresistance towards 5-Fluorouracil in human pancreatic carcinoma cells
Background: In the present study, we aimed to identify and to eliminate putative cancer stem cells (CSC) within different human pancreatic cancer cell lines as well as within 5-Fluorouracil-resis...
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Chapter and Conference Paper
The role of Endothelial Cell-Selective Adhesion Molecule (ESAM) for leukocyte migration and vascular permeability during hepatic ischemia-reperfusion
Background: The endothelial receptors that control leukocyte transmigration in the postischemic liver are not identified. This study was designed to investigate the role of endothelial cell selec...
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Chapter and Conference Paper
Selection of efficient drugs for the therapy of gastrointestinal cancers using the multicellular spheroid model
Advanced gastrointestinal tumors have a poor prognosis and are largely unresponsive to currently available chemotherapeutic drugs. The development of more effective therapies would be aided by better preclinic...
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Chapter and Conference Paper
Improvement of translational and clinical research introducing quality management
Health care is facing efficiency (quality) problems while costs are exploding. Quality management (QM) therefore becomes a major strategic challenge. Thus, the international QM system ISO9001:2000 was introduc...
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Chapter and Conference Paper
Overexpression of the gene IFIT3 enhances tumor growth, angiogenesis, metastasing and chemoresistance of the pancreas carcinoma cells
Background: Pancreas carcinoma belongs to one of the most dangerous tumor disease. Therefore it is very important to understand mechanism leading to change of the low angiogenic and low metastati...
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Chapter and Conference Paper
A phase I/II clinical trial in patients with locally advanced and/or metastatic pancreatic cancer using a combination of low dose chemotherapy and RAD 001
Background: We like to prove with this study concept whether intrinsically resistant locally advanced and/or metastatic pancreatic cancer can be treated with a combination of antiangiogenic thera...
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Chapter and Conference Paper
Einsatz muriner mesenchymaler Stammzellen zur Expression spenderspezifischer MHC Klasse I Moleküle zur spenderspezifischen Immunsuppression in der allogenen Organtransplantation
Transplantation tolerance is one of the most important issues in organ transplantation. It has previously been shown in murine animal models that pre-treatment of organ recipients with soluble MHC class I (MHC...
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Chapter and Conference Paper
Einfluss der Immunsuppression auf die Mikrozirkulation: Erste Ergebnisse einer prospektiven Studie an gesunden Probanden und Patienten nach Nierentransplantation
Introduction: Modern immunosuppressives have markedly improved graft survival after solid organ transplantation. However, these substances are associated with negative effects on transplant funct...
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Chapter and Conference Paper
Rekombinantes humanes Augmenter of liver regeneration (rhALR) verbessert die Leberregeneration nach Leberresektion an der Ratte
Background: Augmenter of liver regeneration (ALR) is an endogenous protein, which shows increased expression after liver resection but that also acts as a liver specific growth factor. In vitro s...
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Chapter and Conference Paper
Prädiktion des Therapieansprechens beim kolorektalen Karzinom im multizellulären Sphäroidmodell: Sphero-PCT-Studie
Background: Despite significant advances in conventional therapeutic approaches, the five-year overall survival rate of CRC patients with an intended curative resection (R0) is less than 50 %. Th...
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Chapter and Conference Paper
Tumorstammzell-gerichtete Therapie mit Rapamycin und Cyclopamin sensitiviert chemotherapieresistente Pankreaskarzinome gegenüber 5-Fluorouracil
Background: The contribution of cancer stem cells (CSC) to pancreatic cancer has not been established yet. Furthermore, the presence of cancer stem cells in chemotherapy-resistant pancreatic canc...
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Chapter and Conference Paper
Assoziation der MICA/MICB-Allele mit der Progression kolorektaler Karzinome
Introduction: The major histocompatibility complex class I related A (MICA) and MICB molecules are ligands of NKG2D receptors on gamma/delta natural killer cells and CD8aß T cells and mediate hos...
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Chapter and Conference Paper
Ex vivo Therapie maligner Pleuraergüsse beim metastasierten Mammakarzinom mit dem bispezifischen anti EpCAM/CD3 Antikörper MT110
Aim: Despite therapy, approximately half of patients with metastatic breast cancer develop a malignant pleural effusion (MPE) associated with short survival. Hence, new treatment strategi...
