2,577 Result(s)
within
Conference Paper
**e **an
Virology
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Chapter and Conference Paper
Discussion/Chapter 19
Dr. Wecker reemphasized the point made earlier that by the time the viral agent has reached the central nervous system (CNS), the immunologic response was unlikely to cope with the infection. In line with this...
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Chapter and Conference Paper
Conclusions: Outlook on Future Research
A great variety of slow or persistent virus infections have been discussed, and each of these infections has its own fascination for us. We must, however, come to grips with the central problems that we face. ...
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Chapter and Conference Paper
Discussion/Chapter 20
Dr. zur Hausen began by asking whether there were any epidemiologic criteria by which multiple sclerosis (MS), or any other disease, could be considered either an infectious disease or not. Dr. MacMahon respon...
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Chapter and Conference Paper
Borna Disease: Patterns of Infection
Cultivation of borna virus in vitro (5, 8, 9, 10, 11) and infectivity titration through immunofluorescence (12) made extensive laboratory studies with this agent possible. Borna virus has a wide host rangein vivo
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Chapter and Conference Paper
Progressive Multifocal Leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating disease apparently resulting from the selective destruction of oligodendrocytes by papovaviruses. The pathology and pathogenesis of ...
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Chapter and Conference Paper
Comment/Chapter 6
Dr. Johnson raised some interesting points. The first is in regard to the cause of progressive multifocal leukoencephalopathy (PML). Are all three of the papova-viruses etiologically involved? If so, how many ...
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Chapter and Conference Paper
Comment/Chapter 7
Dr. Katz’s discussion is a very concise and lucid exposition on the value of a genome rescue on the resolution of the etiology of a disease. Using this approach, we have (uncovered a potential candidate for in...
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Chapter and Conference Paper
Discussion/Chapter 9
Dr. Johnson commented on the progressive encephalitis of rubella. It resembles subacute sclerosing panencephalitis (SSPE) in the prolonged “incubation period” of some 12 years and the clinical picture of intel...
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Chapter and Conference Paper
Scrapie: Pathogenesis in Inbred Mice: An Assessment of Host Control and Response Involving Many Strains of Agent
Scrapie is a fatal progressive degenerative disorder of the central nervous system that occurs as a natural infection in sheep and goats. It is transmissible experimentally to various species, including mice, ...
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Chapter and Conference Paper
Comment/Chapter 8
It is worth illustrating a morphologic technique for the study of cells in productive and resistant infections. We have used surface replica technique, which provides a simple means for looking at the outer su...
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Chapter and Conference Paper
Multiple Sclerosis: A Case for Viral Etiology
Multiple sclerosis (MS) is currently a leading candidate among human diseases for consideration as a slow virus infection (SVI). Although un-equivocal data that would permit us to define MS as a viral disease ...
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Chapter and Conference Paper
Discussion/Chapters 1–2
Dr. Dickinson pointed out that his classification of the various scrapie agents was more agent-oriented than animal-oriented. Therefore, in his presentation, it was one strain of scrapie that produced more pla...
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Chapter and Conference Paper
Characterization of the Virus Antibody Activity of Oligoclonal IgG Produced in the Central Nervous System of Patients with Multiple Sclerosis
There is at present no convincing direct evidence of a virus in the central nervous system (CNS) of multiple sclerosis (MS) patients. As mentioned by others, the evidence for such a virus is indirect, that is,...
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Chapter and Conference Paper
Sheep Progressive Pneumonia Viruses
Sheep throughout the world are susceptible to a viral progressive interstitial pneumonia. Recently, agents responsible for this disorder have been the object of much scientific scrutiny. On the one hand, they ...
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Chapter and Conference Paper
Demyelination in Experimental Allergic Encephalomyelitis and Multiple Sclerosis
Experimental allergic encephalomyelitis (EAE) can be produced by the very simple technique of a single intradermal injection of normal central nervous system (CNS) tissue with FreuncTs complete adjuvants, kill...
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Chapter and Conference Paper
Comment/Chapters 13–15
The virologic and genetic concepts may actually obscure the principal issue, i.e., the identification of the cause or causes of multiple sclerosis (MS). Epidemiologic data strongly suggest that some environmen...
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Chapter and Conference Paper
Comment/Chapter 3
Dr. Harter demonstrated for us the structure of visna virus. I would like to elaborate this subject by pointing out the difference in size between the budding virus and the complete virus (Fig. 3A.1). The buds...
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Chapter and Conference Paper
Cell-Mediated Immunity in Multiple Sclerosis
There is little doubt that immunologic processes play an important role in the pathogenesis of multiple sclerosis (MS). Here we shall review certain aspects of cell-mediated immunity (CMI) in MS, as it may be ...
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Chapter and Conference Paper
Temperature-Sensitive Viruses: Possible Role in Chronic and Inapparent Infections
For the last 5 years my colleagues and I have been working on cell culture models of persistent viral infections. Currently, our hypothesis concerns the establishment and maintenance of certain persistent infe...
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Chapter and Conference Paper
Borna, the Disease—A Summary of Our Present Knowledge
Borna, a viral disease of horses and sheep, has been known for more than 150 years. The clinical picture was first described in 1813 as “Hitzige Kopfkrankheit der Pferde,” and the name borna derives from a town i...
