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Current Topics Regarding the Function of the Medial Temporal Lobe Memory System
The first clear insight that the medial temporal lobe of the human brain was in fact a system of anatomically connected structures that were...
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Post-traumatic Epilepsy and Neuropsychiatric Comorbidities
Post-traumatic epilepsy (PTE) is a form of acquired epilepsy that arises from traumatic brain injury (TBI). It presents a complex relationship with...
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A Nasty, Brutish, and Short History of Amphibian Bioacoustics
From prehistoric times, humans have certainly been aware of the existence of sounds of frogs and toads. The significance of sounds for mating was...
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Surface Glutamate Receptor Nanoscale Organization with Super-Resolution Microscopy (dSTORM)
Glutamate receptors mediate the majority of excitatory transmission in the central nervous system. Recent developments in super-resolution...
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Synaptic Integration at Neuron-OPC Synapses
The synapses between neurons and oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS) have similar ultrastructures as...
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Quantitative Analysis of Single Glutamatergic Vesicles in the Brain
Amperometry is an electrochemical method that can provide quantitative as well as kinetic information on neurotransmitter release from single...
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Electrophysiological Recordings of Oligodendroglia in Adult Mouse Brain Slices
Communication between neurons and oligodendrocyte lineage cells has attracted a great interest since multiple discoveries revealed its important...
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Chemogenetic Approaches to Study Astrocytes at Glutamatergic Synapses
Chemogenetic modulation, via the use of designer receptors exclusively activated by designer drugs (DREADDs), is an established in vivo approach that...
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Magnetic Resonance Spectroscopy (MRS) in Alzheimer’s Disease
MRS is a noninvasive technique to measure different metabolites in the brain. Changes in the levels of certain metabolites can be used as surrogate...
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Mass Spectrometry-Based Metabolomics Multi-platform for Alzheimer’s Disease Research
The integration of complementary analytical platforms is nowadays the most common strategy for comprehensive metabolomics analysis of complex...
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Analysis of Resting-State Functional Magnetic Resonance Imaging in Alzheimer’s Disease
Alzheimer’s disease (AD) has been characterized by widespread network disconnection among brain regions, widely overlap** with the hallmarks of the...
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Pharmacodynamics: Mechanism of Drug Action
Pharmacodynamics is the study of mechanisms behind drug actions. It helps us understand the behaviour of drugs inside a body and the way body reacts...
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Drugs Affecting Gastrointestinal Functions
The digestive system in humans is the mechanism that the body uses to carry out digestion. Food is ingested by the digestive system, which is...
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Drugs Acting on Autonomic Nervous System
The autonomic nervous system is largely distributed throughout the body and controls the autonomic and visceral functions, which occur without...
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Impact of Artificial Intelligence on the Treatment of Spinal Cord Injury
The role of artificial intelligence (AI) in healthcare and healthcare administration has been under increasing focus as providers search for more...
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Intelligenzleistungen bei nichtmenschlichen Tieren
Welche Einsicht haben Tiere in ihr Handeln, haben sie ein mit den Menschen vergleichbares bewusstes Erleben ihrer Umwelt? Die Erforschung von...
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Drugs Acting on Renal and Cardiovascular Function
Cardiovascular medications play a crucial role in medical practice by influencing the functionality of the heart and blood vessels. These medications...
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Behavioral Assays Dissecting NMDA Receptor Function in Zebrafish
Zebrafish are a powerful system to study brain development and to dissect the activity of complex circuits. One advantage is that they display...
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Single-Molecule FRET Analyses of NMDA Receptors
Single-molecule fluorescence resonance energy transfer (smFRET) enables the real-time observation of conformational changes in a single protein...
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Characterizing Functional Contributions of Specific GluN2 Subunits to Individual Postsynaptic NMDAR Responses Using Biophysical Parameters
The NMDAR is a heterotetramer composed of two GluN1 subunits and two GluN2 and/or GluN3 subunits, with the GluN2 subunits exhibiting significant...