75 Result(s)
within
English
Physics
Biochemistry, general
Neurosciences
Yi** **
Chapter
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Chapter and Conference Paper
Uptake of the Anticancer Porphyrin Mixture Photofrin II by Human Fibroblasts From Low Density Lipoprotein, High Density Lipoprotein and Albumin
Porphyrin derivatives are increasingly used in the phototherapy of cancers. Previous works (1, 2) demonstrated that when injected intraveineously in man, porphyrins such as protoporphyrin are bound not only to...
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Chapter and Conference Paper
Photoradiation Therapy of Rodent Tumors
The evaluation of a new modality of cancer treatment requires quantitative measurements of tumor- as well as normal tissue response. Since photoradiation therapy (PDT) also involves injection of a photosensiti...
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Chapter and Conference Paper
Photolysis of the Photosensitizers Bithionol and Fentichlor
Antiseptic preparations containing bithionol (BT, 2,2′-thiobis(4,6-dichlorophenol)) and fentichlor (FT, 2,2′-thiobis(4-chlorophenol)) have been reported to cause contact photoallergy1,2, a delayed hypersensitivit...
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Chapter and Conference Paper
Biological Target Molecules and Cell Structures in Mammalian Cell Photosensitisation
Mammalian cells, except specialized pigmented cells such as erythrocytes, melanocytes or visual cells, in normal conditions contain few chromophores absorbing light in the range of the sunlight wavelengths and...
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Chapter and Conference Paper
Porphyrin-Protein Interaction
Several proteins are able to bind porphyrins, but because of their function few are interacting specifically. These few proteins are enzymes in the heme biosynthetic pathway and proteins like the so-called Z-p...
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Chapter and Conference Paper
Phthalocyanines as Sensitizers for Photodynamic Therapy of Cancer
Photodynamic therapy (PDT) of neoplasms using photosensitizers and red light, is currently undergoing clinical trials throughout the world.1 The sensitizer preparation used almost exclusively in PDT consists of a...
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Chapter and Conference Paper
Nuclear Damage in Mammalian Cell Photosensitisation
Photoreactions induced by sensitisers may have significant effects on cellular metabolism by alteration of transport activities and energetic metabolism, leading to derangements in cell capacity to perform mac...
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Chapter and Conference Paper
Sunlight, Melanogenesis, and Free Radicals in the Skin
Melanin, a biopolymer of quinone and hydroquinone monomer units, is found throughout the animal and plant kingdoms. It is largely responsible for pigmentation in animals and contains both concentrations of met...
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Chapter and Conference Paper
Zn-Phthalocyanine as a Possible Phototherapeutic Agent for Tumours
The use of phthalocyanines as photosensitizers in the photodynamic therapy (PDT) of tumours is raising the interest of several research and clinical groups because of the large potential advantages of these dy...
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Chapter and Conference Paper
Damage to DNA Repair in Murine L929 Fibroblasts Induced by the Photodynamic Action of HPD
Photodynamic therapy with HPD as sensitizer causes destruction of malignant tumors. In this context a detailed study of the photodynamic effects of HPD on various cellular parameters is in progress to elucidat...
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Chapter and Conference Paper
Melanin and Photoprotection
It has been reported that the more pigmented an individual is the lower the risk that he will be adversely affected by ultraviolet (UV) radiation. This means that pigmented people are at a lower risk to develo...
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Chapter and Conference Paper
In vivo Fluorescence from Mouse Skin: Spectral Evidence for the Presence of Chlorophyll Derivatives
The technique of fluorescence spectroscopy is a convenient and rapid physical method for the detection and monitoring of chemicals in vivo. It has recently been shown that such a technique can easily monitor the ...
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Chapter and Conference Paper
Alternative Syntheses of ‘DHE’ Analogues
The chemical nature of the tumour-localising component of HPD although thought to be a dihaematoporphyrin ester or ether (DHE) has not been fully established.
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Chapter and Conference Paper
Melanogenesis and Light Regulated Experimental Carcinogenesis
Experimental carcinogenesis by chemical carcinogens (7.12 DMBA and Safrole) can be modulated by light conditions, through pineal gland activity. Three sets of results on the effects induced by DMBA through lig...
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Chapter and Conference Paper
Fluorescence Diagnosis and Photodynamic Therapy — Evaluation of Sensitizers by Comparison of their Pharmacokinetics
Several substances are known to show a temporary difference between their concentrations in normal and tumorous tissue after systemic application. This difference is due to the different kinetics of metabolism...
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Chapter and Conference Paper
A Dose Response Study of Two Purpurins on the AY-27 Rat Bladder Tumor
We have previously reported on a morphologic study of the effect of various purpurins on tumors, in vivo, suggesting that purpurins may be good alternatives to hematoporphyrin derivative (HpD) for the photodyn...
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Chapter and Conference Paper
Skin and Related Photoreactions
Skin reactions to sunlight may be broadly classified as normal, the varying degrees of inflammation known as sunburn, suntan and over a long period, the more serious changes culminating in skin cancer, and abn...
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Chapter and Conference Paper
Bichromophoric Systems to Study the Base-Psoralen Photoreactions
The photosensitising properties of psoralens such as 1 and 2 have been generally related to their (2+2) photoaddition onto the pyrimidine bases of DNA. In recent years a number of results have been obtained regar...
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Chapter and Conference Paper
Potential Phototoxicity in the Photosensitive Patient
All patients given therapeutic doses of hematoporphyrin derivative (HpD) develop clinically significant skin photosensitivity that persists for several weeks to several months following injection. During this ...
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Chapter and Conference Paper
Psoralens: A Review
Furocoumarins (psoralens and isopsoralens) are natural products, occurring especially in the Umbelliferae, Rutaceae and Leguminosae (Musajo and Rodighiero 1972). They have also been isolated from microorganism...
