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Damage to DNA Repair in Murine L929 Fibroblasts Induced by the Photodynamic Action of HPD

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Photosensitisation

Part of the book series: NATO ASI Series ((ASIH,volume 15))

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Abstract

Photodynamic therapy with HPD as sensitizer causes destruction of malignant tumors. In this context a detailed study of the photodynamic effects of HPD on various cellular parameters is in progress to elucidate the ultimate cause of cell death in photodynamic therapy. It has been shown that membrane transport systems and enzymes can be inhibited (1–3). In addition, damage to DNA has also been described (4–8). In this contribution we report the photodynamic effects of HPD on the repair kinetics of DNA damage induced by X-rays, UV-light and the methylating agent methyl methanesulphonate in murine L929 fibroblasts.

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Authors and Affiliations

  1. Department of Medical Biochemistry, University of Leiden, P.O.Box 9503, 2300 RA, Leiden, The Netherlands

    J. P. J. Boegheim, T. M. A. R. Dubbelman & J. Van Steveninck

  2. Sylvius Laboratories, University of Leiden, P.O.Box 9503, 2300 RA, Leiden, The Netherlands

    J. P. J. Boegheim, T. M. A. R. Dubbelman & J. Van Steveninck

Authors
  1. J. P. J. Boegheim
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  2. T. M. A. R. Dubbelman
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  3. J. Van Steveninck
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Editor information

Editors and Affiliations

  1. Laboratoire de Biophysique, INSERM U 201, CNRS UA 481, Rue Buffon, 75005, Paris, France

    Giuliana Moreno

  2. Muséum National d’Histoire Naturelle 61, Rue Buffon, 75005, Paris, France

    Giuliana Moreno

  3. Department of Chemistry and Chemical Engineering, Royal Military College of Canada Kingston, K7K 5LO, Ontario, Canada

    Roy Henry Pottier

  4. Department of Chemistry, Paisley College, PA1 2BE, Paisley, Scottland,UK

    Terence George Truscott

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© 1988 Springer- Verlag Berlin Heidelberg

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Boegheim, J.P.J., Dubbelman, T.M.A.R., Van Steveninck, J. (1988). Damage to DNA Repair in Murine L929 Fibroblasts Induced by the Photodynamic Action of HPD. In: Moreno, G., Pottier, R.H., Truscott, T.G. (eds) Photosensitisation. NATO ASI Series, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73151-8_28

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  • DOI: https://doi.org/10.1007/978-3-642-73151-8_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73153-2

  • Online ISBN: 978-3-642-73151-8

  • eBook Packages: Springer Book Archive

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