127 Result(s)
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Chapter
Wen-**g **ng
Biomedicine
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Ring Chromosome 19
Ring chromosome 19 (RC19) is a rare genetic abnormality with variable clinical manifestations, ranging from normalcy to developmental and intellectual disabilities. However, there is no specific and recognizab...
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Decentralized Neural Circuits of Multisensory Information Integration in the Brain
The brain combines multisensory inputs together to obtain a complete and reliable description of the world. Recent experiments suggest that several interconnected multisensory brain areas are simultaneously in...
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PABPC1: A Novel Emerging Target for Cancer Prognostics and Anti-cancer Therapeutics
Cancer is a diverse group of diseases predominantly characterized by uncontrolled cellular proliferation. Tumour cells can invade healthy tissues and, in severe cases, metastasize, leading to an overall declin...
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Personalized Immuno-Oncology with Immunodeficiency Mouse Models
In the past decades, cancer therapies are evolved from a non-specific approach to a precise and accurate therapy. Precision (or personalized) cancer therapy, in which a patient’s own tumor information is used ...
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Insoluble Cellular Prion Protein and Other Neurodegeneration-Related Protein Aggregates in the Brain of Asymptomatic Individuals
The pathological detergent-insoluble prion protein (PrPSc) is derived from its normal detergent-soluble cellular form (PrPC) through a structural transition from α-helixes into β-sheets, which is associated with ...
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Seeding Activity of Skin Misfolded Proteins as a Biomarker in Prion and Prion-Like Diseases
Prion disease (PrD) and other prion-like diseases, including but not limited to Alzheimer’s disease (AD) and Parkinson’s disease (PD), are characterized by the accumulation and deposition of misfolded proteins...
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Surface Modification of Tissue Engineering Scaffolds
Scaffolds in tissue engineering provide a substrate for cells to grow on, in order to form functional, organised tissue. The ideal scaffold thus possesses mechanical properties to cope with physiological loads...
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Glycoform-Selective Prions in Sporadic and Genetic Variably Protease-Sensitive Prionopathies
Unlike other human prion diseases, including the most common Creutzfeldt–Jakob disease (CJD), variably protease-sensitive prionopathy (VPSPr) is characterized by the deposition of a unique glycoform-selective ...
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Learning from Zebrafish Hematopoiesis
Hematopoiesis is a complex process that tightly regulates the generation, proliferation, differentiation, and maintenance of hematopoietic cells. Disruptions in hematopoiesis can lead to various diseases affec...
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Protective Role of Cellular Prion Protein in Tissues Ischemic/Reperfusion Injury
Normal cellular prion protein (PrPC) is well documented to be the precursor of the infectious pathogenic prion protein that plays a critical role in the pathogenesis of prion diseases, a group of fatal transmissi...
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Multivariate Curve Resolution for Analysis of Heterogeneous System in Toxicogenomics
The utilization of genetic data to investigate toxicological problems has become an imperative approach. Toxicogenomics (TGx), as a specialty branch created by the merger of Genomics and Toxicology, has genera...
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Neurobiological Mechanism of Acupuncture Analgesia in Chronic Somatic Pain
Acupuncture reduces pain by activating specific areas called acupoints on the patient’s body. When these acupoints are fully activated, sensations of soreness, numbness, fullness, or heaviness called De qi or ...
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Analgesic Effects of Acupuncture on Orofacial Pain
Orofacial pain includes trigeminal neuralgia, headache, migraine, painful temporomandibular dysfunction, toothache, and other oral and facial pain. Orofacial pain is one of the most severe types of pain, and i...
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Advances in Development of mRNA-Based Therapeutics
Recently, mRNA-based therapeutics have been greatly boosted since the development of novel technologies of both mRNA synthesis and delivery system. Promising results were showed in both preclinical and clinica...
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Acupuncture and Alzheimer’s Disease
Alzheimer’s disease (AD) is the main cause of dementia and one of the most common kinds of neurodegenerative diseases. However, its etiology and pathophysiology remain unclear and effective treatments for it a...
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Treatment of Cheyne-Stokes Respiration in Heart Failure with Adaptive Servo-Ventilation: An Integrative Model
The SERVE-HF (Treatment of Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients with Heart Failure) multicenter trial found a small but significant increase in all-cause and cardiovascular...
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High Level of Inflammation
In low concentration, fluoride is considered a necessary compound for human health. Long-term exposure to excessive content of fluoride is the reason for a disease called fluorosis. In more than 25 countries a...
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Plant Natural Products for Mitigation of Antibiotic Resistance
The emergence of antibiotic resistance and in particular multi drug resistance is of great threat to human health worldwide. Amid the ongoing efforts to search for novel antibacterial agents as alternatives to...
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Cognitive-Enhancing Substances and the Develo** Brain: Risks and Benefits
Growing competitiveness in education and workplaces has led to increased interest in cognitive-enhancing substances. Abuse of prescription drugs purported to offer nootropic potential is increasing, and new br...
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Inwardly Rectifying K+ Channel 4.1 Regulates Renal K+ Excretion in the Aldosterone-Sensitive Distal Nephron
The inwardly rectifying potassium channel 4.1 (Kir4.1, KCNJ10) in the aldosterone-sensitive distal nephron (ASDN) plays a key role in the regulation of Na+ and K+ transport by sensing the dietary K+ and Na+ intak...
