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    Chapter and Conference Paper

    Use of Hydrocyclone as an Efficient Tool for Cell Retention in Perfusion Cultures

    A new specially designed hydrocyclone was successfully applied as cell separation system in 6-L and 30-L continuously perfused bioreactors. Cell concentration reached up to 10 million per mL and viability rema...

    E.A. Elsayed, G.-W. Piehl, J. Nothnagel… in Animal Cell Technology Meets Genomics (2005)

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    Chapter

    Induction Kinetics of Apoptosis in Mammalian Cell Cultures

    The morphological and biochemical features of cell death in three production cell lines and one human carcinoma cell line were characterised in order to investigate the kinetics of apoptosis induction, apoptot...

    M. Linz, A.-P. Zeng, W.-D. Deckwer in Animal Cell Technology: Products from Cell… (2002)

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    Chapter

    The Use of Hydrocyclones for Mammalian Cell Retention in Perfusion Bioreactors

    A new type of hydrocyclone was designed and used in continuous mammalian cell cultivation processes. The apparatus gave cell separation efficiencies as high as 99%. Due to the fact that a 5-L-bioreactor was us...

    A. Jockwer, Prof Ricardo A. Medronho… in Animal Cell Technology: From Target to Mar… (2001)

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    Chapter

    Separation of Mammalian Cells Using a Specially Designed Rotating Disc Filter

    Through continuous fresh nutrient supply and metabolite removal, combined with cell retendon in the bioreactor, perfusion cultures allow high cell concentrations and product titres to be achieved at relatively...

    Ms Leda R. Castilho, F. Birger Anspach… in Animal Cell Technology: From Target to Mar… (2001)

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    Chapter

    A New Approach for Development of Structured Growth Models

    Mathematical modelling and simulation are widely applied for getting a deeper understanding of biotechnological processes and having a closer look into reactors and microorganisms. Models were developed for si...

    K.-H. Bellgardt, N. Hopf, R. Luttmann… in Computer Applications in Fermentation Tech… (1989)

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    Chapter

    Gas/Liquid Mass Transfer Parameters (εG, kLa, a) for Non-Newtonian Two-Phase Flow in a Bubble Column

    Gas/liquid mass transfer at non-Newtonian flow occurring, e.g., in aerobic fermentation is studied using highly viscous pseudoplastic solutions of sodium carboxymethylcellulose (CMC) as a model medium. Aeratio...

    A. Schumpe, K. Nguyen-tien, W.-D. Deckwer in Mass Transfer with Chemical Reaction in Mu… (1983)

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    Chapter

    Influence of Nonuniform Catalyst Distribution on the Performance of the Bubble Column Slurry Reactor

    With regard to an effective use of catalyst it is necessary to realize a uniform distribution over the entire reactor. There are a number of experimental studies reported in the literature (1–5) which show tha...

    Y. Serpemen, W.-D. Deckwer in Mass Transfer with Chemical Reaction in Multiphase Systems (1983)

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    Chapter

    Physical Transport Phenomena in Biological Tower Reactors

    It is well known that the performance of biological processes may be influenced significantly by physical transport phenomena. In general, physical transport processes concern the transfer of mass, momentum an...

    W.-D. Deckwer in Mass Transfer with Chemical Reaction in Multiphase Systems (1983)

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    Chapter

    Some Aspectcs of Gas Absorption Mechanism in Slurry Reactors

    Slurry reactors are popular in industry where the solids either take part in the reaction or act as catalyst.Many aspects of these reactors, particularly for catalytic systems, have been discussed at length in...

    Erdogan Alper, W.-D. Deckwer in Mass Transfer with Chemical Reaction in Multiphase Systems (1983)