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    Chapter

    Principles of Checkpoint Inhibition in Malignant Lymphoma

    Malignancies manipulate the physiologic immune system through various immune checkpoint pathways to antagonize T cell activation and provide themselves an immune escape advantage. Targeting these inhibitory si...

    Kitsada Wudhikarn, Stephen M. Ansell (2022)

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    Chapter

    Tumor Microenvironment in T-Cell Lymphomas

    T-cell lymphomas (TCL) are uncommon non-Hodgkin lymphomas that often have an aggressive clinical course. Patients typically have limited treatment options upon relapse and a dismal prognosis after progression ...

    N. Nora Bennani, Stephen M. Ansell in T-Cell and NK-Cell Lymphomas (2019)

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    Chapter

    Waldenstrom Macroglobulinemia: Genomic Aberrations and Treatment

    Waldenström macroglobulinemia (WM) is a rare, indolent, and monoclonal immunoglobulin M-associated lymphoplasmacytic disorder with unique clinicopathologic characteristics. Over the past decade, remarkable pro...

    Prashant Kapoor, Stephen M. Ansell, Esteban Braggio in Plasma Cell Dyscrasias (2016)

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    Chapter

    Tip** the Scales of Survival: The Role of BLyS in B-Cell Malignancies

    Some of the genetic changes that lead to B-cell transformation, such as chromosomal rearrangements, have been discovered, but many of the other contributing mechanistic details underlying transformation events...

    Anne J. Novak, Stephen M. Ansell in BLyS Ligands and Receptors (2010)