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Chapter
Toxicology and Risk Assessment of POPs
Polyhalogenated industrial compounds and combustion by-products including the polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) have been identified in almost every component o...
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Chapter and Conference Paper
Der Arylhydrocarbon Rezeptor als neue Zielscheibe zur Behandlung des Pankreaskarzinoms
The arylhydrocarbon receptor (AhR) was initially identified as a member of the adaptive metabolic and toxic response pathway to polycyclic aromatic hydrocarbons and to halogenated dibenzo-p-dioxins and dibenzo...
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Chapter and Conference Paper
Cellular and Molecular Biology of Aryl Hydrocarbon (Ah) Receptor — Mediated Gene Expression
2,3,7,8- Tetr achlorodibenzo-p-dioxin (TCDD) and related compounds elicit diverse toxic and biochemical responses in laboratory animals and mammalian cells in culture. TCDD induces CYP1A1 gene expression and resu...
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Chapter and Conference Paper
PCDDs and PCDFs: Sources and Environmental Impact
Polychlorinated dibenzo-p-dioxins (PCDDs or polyCDDs) and polychlorinated dibenzofurans (PCDFs or polyCDFs) are members of the family of halogenated aromatic chemicals which includes the polychlorinated biphenyls...
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Chapter
Polychlorinated Biphenyls — Human Health Effects
Commercial polychlorinated biphenyls (PCBs) are formulations prepared by the chlorination of biphenyl.1–4 The chlorine content of the products are directly dependent on the relative amount of Cl2 used in the reac...
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Chapter and Conference Paper
Polychlorinated Biphenyls: Environmental Occurrence and Analysis
Polychlorinated biphenyls (PCBs) are complex mixtures which have been identified in every component of the global ecosystem. This chapter discusses the distribution of PCBs in the environment and points out re...
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Chapter and Conference Paper
Mammalian Biologic and Toxic Effects of PCBs
This review outlines the mammalian toxicology of PCBs and several classes of related halogenated aromatic hydrocarbons that are persistent environmental contaminants. PCBs comprise 209 chlorinated derivatives ...
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Chapter and Conference Paper
PCBs and Human Health
Humans have been exposed to polychlorinated biphenyl (PCB) mixtures via 3 major pathways. Several thousand workers engaged in the manufacture and application of PCBs have been exposed to relatively high levels...
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Chapter
Helenalin: Mechanism of Toxic Action
Several range plants, including Hymenoxys odorata (bitterweed) and Helenium microencephalum DC (smallhead sneezeweed) contain toxic principles believed to be the etiologic agents responsible for severe losses of ...
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Chapter
Other Industrial Pollutants and Natural Toxins
Tris(l,3-dichloro-2-propyl)phosphate(I) and tris(2,3-dibromopropyl)-phospate(II) are industrial flame retardants which have been used to impregnate fabrics. The carcinogenicity of II resulted in its ...
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Chapter
PCDDs and Related Compounds: Metabolism and Biochemistry
Polychlorinated dibenzo-p-dioxins and related halogenated aromatic compounds are a group of chemicals which exhibit similar physical and environmental properties and elicit a number of common toxic and biologi...
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Chapter
Further Characterization and Applications of the 4-Chlorobiphenyl Hydroxylase Assay
Studies of the metabolism-mediated covalent binding of halobiphenyls to cellular macromolecules revealed that the in vitro metabolism of 4-chlorobiphenyl (4-CBP) by hepatic microsomes is greatly enhanced by in vi...
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Chapter
Halogenated Biphenyl Metabolism
The metabolism of xenobiotics occurs predominantly in the liver and is generally effected in two related phases. Phase I biotransformation includes oxidation, reduction and hydrolysis which either introduces o...
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Chapter
Ion Kinetic Energy Spectroscopy: A New Mass Spectrometric Method for the Unambiguous Identification of Isomeric Chlorophenols
Ion kinetic energy (IKE) spectroscopy is a technique which records the ionic decompositions which occur in the first field-free region of the mass spectrometer prior to the electric sector1,2. These ions can be r...
