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Chapter
The management of bladder cancer — a case history
Bladder cancer is a common disease, accounting worldwide for approximately 3.5% of all new cancers. It manifests a wide spectrum of disease, ranging from a solitary, papillary, non-invasive lesion, through to ...
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Chapter
The Development of Resistance to Methotrexate in a Human Leukaemia (AML) Growing in Nude Mice
The line was derived by s. c. implantation of 2.4 x 106 leukaemic cells. The resultant solid tumour was shown to be sensitive to methotrexate at its third passage. Development of the resistant line commenced at p...
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Chapter
JM8 Development and Clinical Projects
Since its introduction in the early 1970’s cisplatin has become established as one of the major cytotoxic drugs used in the treatment of cancer. Of particular note are its application in combination therapy to...
