334 Result(s)
within
English
Biomedicine
Pharmacology/Toxicology
Qi** Li
Chapter
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Chapter
Biochemical Actions of Fibroblast Kinin-Forming Protease
Both a neutral (1) and acid (2,3) protease capable of forming kinins from a variety of mammalian substrates have been isolated and purified from the transplanted rodent Murphy-Sturm lymphosarcoma (MSLS). The M...
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Pharmacokinetics and Metabolism of Anticancer Drugs
The design of cancer chemotherapeutic agents would already have evolved from empiricism to rationalism if a unique structural feature exists that specifically confers anticancer activity on a chemical substanc...
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Transforming Activity of Viruses after Dye—Light Inactivation
The phenomenon of photodynamie inactivation was first reported by Raab (1) at the beginning of this century (he observed that paramecia lived while suspended in acridine orange solution and kept in the dark, b...
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Chromium and Vanadate Supplementation of Obese and Lean Mice
Chromium (Cr) is essential for normal carbohydrate and lipid metabolism in both animals and humans. Severe chromium deficiency in experimental animals may contribute to insulin resistance, impaired glucose tol...
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Acute Ganglioside Effects Limit CNS Injury
There are many reports that ganglioside treatment of animals following CNS injury results in facilitated recovery. One mechanism by which gangliosides promote recovery may be their acute effect (“protection”) ...
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Structural Analysis of a Rat Renal Kallikrein Gene
A renal kallikrein gene has been isolated, sequenced and characterized from a rat genomic library using a kallikrein cDNA probe. The kallikrein gene is 4160 bases in length and consists of 5 exons and 4 intron...
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Serotonin and Ethanol Preference
This chapter brings together evidence indicating the involvement of serotonin (5-HT) in ethanol preference using data mainly obtained from selectively bred alcohol-preferring and alcohol-nonpreferring lines of...
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Immunological Methods for the Detection of Polycyclic Aromatic Hydrocarbon-DNA and Protein Adducts
Sensitive immunological methods are now available for the detection and quantitation of carcinogen-DNA and protein adducts. Both monoclonal and polyclonal antibodies have been developed against DNA modified by...
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Mutagenicity, Carcinogenicity, and Human Cancer Risk from Indoor Exposure to Coal and Wood Combustion in Xuan Wei, China
The residents in Xuan Wei County, China, have been exposed to high levels of combustion emissions from smoky and smokeless coal and wood combustion under unvented conditions in homes. An unusually high lung ca...
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Kinetics and Mechanism of Methanol and Formaldehyde Interconversion and Formaldehyde Oxidation Catalyzed by Liver Alcohol Dehydrogenase
Liver alcohol dehydrogenase (LADH) is a well-characterized protein. Both its primary and tertiary structures are known, as are some of the catalytic mechanisms, isozyme differences, evolutionary divergences an...
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Platelet-Activating Factor (PAF) Receptor in Brain and Signal Transduction in Neurons
Specific, reversible and saturable binding sites for [3H]-PAF were observed in gerbil brain. Scatchard analysis revealed the existence of two apparent classes of binding sites with Kd1=3.7 nM and Kd2=20.4 nM. The...
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Potential Breast Tumor Imaging Agents: Fluorotamoxifen and Derivatives
This study is aimed at develo** a ligand to be used for imaging estrogen receptor positive breast tumors by Positron Emission Tomography (PET). We describe the synthesis of fluorotamoxifen analogs with the f...
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A Polymorphism in the Rat Liver Mitochondrial ALDH2 Gene is Associated with Alcohol Drinking Behavior
Liver mitochondrial aldehyde dehydrogenase (ALDH2) has a low Km for acetaldehyde and plays a major role in acetaldehyde oxidation in vivo following alcohol consumption. In humans, a single base pair mutation prod...
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Abstracts
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Molecular and Genetic Approaches to Understanding Alcohol-Seeking Behavior
In alcoholism research, two fundamental and related questions are: “why do people drink?” and“why do some people drink too much despite having experienced negative consequences?” Drinking normally occurs in a ...
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Aplysia Californica Contains A Novel 12-Lipoxygenase which Generates Biologically Active Products From Arachidonic Acid
Physiologic stimulation of identified neurons in ganglia of the marine mollusk, Aplysia californica,leads to the generation of arachidonic acid metabolites. Using various preparations of Aplysianervous tissue, we...
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Plant Proteins with Antiviral Activity Against Human Immunodeficiency Virus
Human Immunodeficiency Virus (HIV), the etiological agent of acquired immunodeficiency syndrome (AIDS), is a member of the lentiviruses, a subfamily of retroviruses. Unlike other retro-oncoviruses, HIV is not ...
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Enzymes For Synthesis of 10-Formyltetrahydrofolate in Plants: Characterization of a Monofunctional 10-Formyltetrahydrofolate Synthetase and Copurification of 5,10-Methylenetetrahydrofolate Dehydrogenase and 5,10-Methenyltetrahydrofolate Cyclohydrolase Activities
Plants require folates for the biosynthesis of purines, serine, methionine, formylmethionyl-tRNA and thymidylate (1). In leaves, mitochondrial folates mediate glycine cleavage and serine formation during photo...
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Serotonin Regulation of Alcohol Drinking
Rat lines selectively bred for their disparate alcohol drinking behavior exhibit differences in their CNS serotonin (5-HT) systems. The alcohol-preferring P line has lower contents of 5-HT and fewer immunostai...
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Increased Activity of γ-Glutamyl Hydrolase in Human Sarcoma Cell Lines: A Novel Mechanism of Intrinsic Resistance to Methotrexate (MTX)
Intracellular levels of folate or methotrexate (MTX) polyglutamates are regulated at least in part by the enzyme, folylpolyglutamate synthase (FPGS), which is responsible for synthesis, and γ-glutamate hydrola...
