334 Result(s)
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English
Biomedicine
Pharmacology/Toxicology
Qi** Li
Chapter
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Monoclonal Antibodies: From Structure to Therapeutic Application
The exciting field of therapeutic monoclonal antibodies (mAbs) had its origins when Köhler and Milstein presented their murine hybridoma technology in 1975 (Kohler, Milstein. Nature. 256(5517):495–497, 1975). ...
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Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Targeted Therapeutics for Cystic Fibrosis
Treatment of the common life-limiting genetic disease cystic fibrosis (CF) has been transformed by small molecule therapeutics that target the root cause of the disease, pathogenic variants in the ATP-binding ...
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Exotoxins of Staphylococcus aureus
Staphylococcus aureus produces a variety of exotoxins, which are important virulence factors for S. aureus-related diseases. Representatively, staphylococcal enterotoxins induce staphylococcal food-born poisoning...
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Correction to: Therapeutics and Diagnostics Discovery
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Aquaporins in Edema
One of the most prevalent indications of water–electrolyte imbalance is edema. Aquaporins (AQPs) are a protein family that can function as water channels. Osmoregulation and body water homeostasis are dependen...
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Non-Transport Functions of Aquaporins
Although it has been more than 20 years since the first aquaporin was discovered, the specific functions of many aquaporins are still under investigation, because various mice lacking aquaporins have no signif...
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Aquaporins in Nervous System
Aquaporins (AQPs) mediate water flux between the four distinct water compartments in the central nervous system (CNS). In the present chapter, we mainly focus on the expression and function of the nine AQPs ex...
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Unique Features of the Human Sinoatrial Node Structure, Function, and Arrhythmias: Mechanistic Insights from Integrated 3D Map** Approaches
The sinoatrial node (SAN) is the primary pacemaker in mammalian hearts, which generates intrinsic electrical activation to maintain synchronous and rhythmic contractility of the heart. Impairments in SAN struc...
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Lysosomal Ion Channels and Lysosome–Organelle Interactions
Intracellular organelles exchange their luminal contents with each other via both vesicular and non-vesicular mechanisms. By forming membrane contact sites (MCSs) with ER and mitochondria, lysosomes mediate bidir...
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Biopharmaceutical Potential of Ophiocordyceps sinensis for Human Health
Ophiocordyceps sinensis is an entomopathogenic fungus used in traditional Chinese and Tibetan medicine for over 2000 years. It is also commonly consumed in Asia for nutritional purposes. To authenticate the vario...
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Therapeutics and Diagnostics Discovery
In any therapeutics discovery and development effort, multiple critical steps must be accomplished to arrive at a compound that is safe and efficacious, while also exhibiting the complex array of desired drug-...
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Aquaporins in Urinary System
There are at least eight aquaporins (AQPs) expressed in the kidney. Including AQP1 expressed in proximal tubules, thin descending limb of Henle and vasa recta; AQP2, AQP3, AQP4, AQP5, and AQP6 expressed in col...
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Protein Structure and Modification of Aquaporins
Aquaporins (AQPs) allow water molecules and other small, neutral solutes to quickly pass through membrane. The protein structures of AQPs solved by crystallographic methods or cryo-electron microscopy technolo...
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Aquaporins in Cardiovascular System
Recent studies have shown that aquaporins (AQPs) are involved in the regulation of cardiovascular function and the development of related diseases, especially in cerebral ischemia, congestive heart failure, hy...
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Mesenteric Organ Lymphatics in Abdominal Inflammation
The understanding of the lymphatic vasculature lags far behind that of the blood vasculature, despite both belonging to vascular circulatory systems. The deepening of our understanding of the mesenteric lympha...
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Imaging Techniques in Pharmacological Precision Medicine
Biomedical imaging is a powerful tool for medical diagnostics and personalized medicines. Examples of commonly used imaging modalities include Positron Emission Tomography (PET), Ultrasound (US), Single Photon...
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A Structural Overview of TRPML1 and the TRPML Family
This chapter explores the existing structural and functional studies on the endo-lysosomal channel TRPML1 and its analogs TRPML2, TRPML3. These channels represent the mucolipin subfamily of the TRP channel sup...
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Classification and Gene Structure of Aquaporins
Aquaporins (AQPs) are a family of membrane water channels that basically function as regulators of intracellular and intercellular water flow. To date, 13 AQPs, distributed widely in specific cell types in var...
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Expression Regulation and Trafficking of Aquaporins
Aquaporins (AQPs) mediate the bidirectional water flow driven by an osmotic gradient. Either gating or trafficking allows for rapid and specific AQP regulation in a tissue-dependent manner. The regulatory mech...
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Toll-Like Receptor 4: A Novel Target to Tackle Drug Addiction?
Drug addiction is a chronic brain disease characterized by compulsive drug-seeking and drug-taking behaviors despite the major negative consequences. Current well-established neuronal underpinnings of drug add...
