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    Chapter

    Statins as Host-Directed Therapy for Tuberculosis

    Statins are a class of drugs that inhibit HMG-CoA reductase, the rate-limiting step in cholesterol biosynthesis, and are commonly used for primary and secondary prevention of cardiovascular disease. In additio...

    Noton K. Dutta, Petros C. Karakousis in Advances in Host-Directed Therapies Agains… (2021)

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    Chapter

    Clinical Features and Diagnosis of Tuberculosis: Primary Infection and Progressive Pulmonary Tuberculosis

    In this chapter, we will review the clinical manifestations of intrathoracic tuberculosis (TB), including pathophysiology and clinical features of primary and secondary or reactivation TB. Specific topics disc...

    Petros C. Karakousis, Noton K. Dutta, Yukari C. Manabe in Handbook of Tuberculosis (2017)

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    Chapter

    Mechanisms of Action and Resistance of Antimycobacterial Agents

    Historically, mycobacterial infections have been associated with signifi cant morbidity and mortality worldwide. In particular, Mycobacterium tuberculosis is a highly successful human pathogen, infecting one-thir...

    Petros C. Karakousis in Antimicrobial Drug Resistance (2009)