8 Result(s)
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Chapter
Lawrence Lumeng
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Chapter
Protein-Acetaldehyde Adducts as Biochemical Markers of Alcohol Consumption
There are two types of diagnostic markers for alcohol abuse and alcoholism: trait (or vulnerability) markers and state markers.1,2 Trait markers include indicators that will identify individuals who are more vuln...
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Formation of a Protein-Acetaldehyde Adduct in Liver during Chronic Alcohol Exposure
Acetaldehyde is an intermediary metabolite of ethanol oxidation that forms in the liver during alcohol ingestion. Formation of acetaldehyde is mediated by two alcohol metabolizing systems: alcohol dehydrogenas...
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Molecular and Genetic Approaches to Understanding Alcohol-Seeking Behavior
In alcoholism research, two fundamental and related questions are: “why do people drink?” and“why do some people drink too much despite having experienced negative consequences?” Drinking normally occurs in a ...
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Alcohol and Hepatic Protein Modification
Although a small percentage of alcohol, after ingestion, can be excreted unchanged in breath and urine, most of its elimination is carried out by enzymatic oxidation. Studies with experimental animals have sho...
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Mechanism(s) of Modulation of Alcohol Consumption: Studies on the P and NP Rats
In several laboratories, lines of rats have been selectively bred for disparate alcohol drinking preferences. Historically, the first lines of rats selectively bred were the UChA (low-alcohol consumer) and UCh...
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Serotonin and Ethanol Preference
This chapter brings together evidence indicating the involvement of serotonin (5-HT) in ethanol preference using data mainly obtained from selectively bred alcohol-preferring and alcohol-nonpreferring lines of...
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Microassay of Pyridoxal Phosphate Using Tyrosine Apodecarboxylase
Pyridoxal 5′-phosphate (PLP) assay based on the coenzyme-dependent decarboxylation of L-tyrosine by tyrosine apodecarboxylase (EC 4.1.1.25) was the first enzymatic method developed in vitamin B-6 analysis. Ori...
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Plasma PLP as Indicator of Nutrition Status: Relationship to Tissue Vitamin B-6 Content and Hepatic Metabolism
In assessment of nutritional status, diagnostic indicators should correlate in a well-defined manner not only with tissue content but also with the functional adequacy of the substance in question. Ideally, th...
