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Central Nervous System Prophylaxis with Intermittent Intrathecal Methotrexate and Fractional Radiation in Childhood Acute Lymphoblastic Leukemia
Following the initial studies of the St. Jude group (1), high dose (2400 rad) cranial irradiation plus intrathecal (IT) methotrexate (MTX) or craniospinal irradiation given shortly after remission induction ha...