SpringerLink
Log in

Central Nervous System Prophylaxis with Intermittent Intrathecal Methotrexate and Fractional Radiation in Childhood Acute Lymphoblastic Leukemia

  • Chapter
Central Nervous System Leukemia

Part of the book series: Developments in Oncology ((DION,volume 13))

  • 49 Accesses

Abstract

Following the initial studies of the St. Jude group (1), high dose (2400 rad) cranial irradiation plus intrathecal (IT) methotrexate (MTX) or craniospinal irradiation given shortly after remission induction has become the ‘standard’ form of CNS prophylactic therapy. This form of CNS prophylactic therapy, based on the CNS sanctuary theory, has been widely used and the results obtained with this approach have been discussed by D’Angio (2), Mauer (3), Bleyer (4) and Hardisty (5) elsewhere in this volume.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

eBook
EUR 9.99
Price includes VAT (France)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
EUR 52.74
Price includes VAT (France)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Aur RJA, Simme J, Husto HO, Walter T, Borella L, Pratt C, Pinkel D: Central Nervous System therapy and continuation chemotherapy of childhood acute lymphoblastic leukemia. Blood 37:272–281, 1971.

    PubMed  CAS  Google Scholar 

  2. D’Angio GJ: Central Nervous System prophylaxis for acute lymphoblastic leukemia of childhood: radiation therapy factors. This issue.

    Google Scholar 

  3. Mauer AM: Central nervous system prophylaxis: the St. Jude experience. This issue.

    Google Scholar 

  4. Bleyer WA: Central Nervous System prophylaxis: Children’s Cancer Study Group results. This issue.

    Google Scholar 

  5. Hardisty RM: Prophylaxis of central nervous system leukemia: recent British experience. This issue.

    Google Scholar 

  6. Zuelzer WW, Ravindranath Y, Lusher JM, Sarnaik S, Considine B: IMFRA (Intermittent Intrathecal Methotrexate and Fractional Irradiation) plus chemotherapy in childhood acute leukemia. Am J Hematology 1:191–199, 1976.

    Article  Google Scholar 

  7. Haghbin M, Murphy ML, Tan CC, Clarkson BD, Thaler HT, Passe S, Burchenal J: A long term clinical follow-up with acute lymphoblastic leukemia treated with intensive chemotherapy regimes. Cancer 46:241–282, 1980.

    Article  PubMed  CAS  Google Scholar 

  8. Sinks L, Wang JJ, Freeman AI: The treatment of primary childhood acute lymphocytic leukemia with intermediate dose Methotrexate. Modern trends in human leukemia IV. (Latest results in clinical biological research including pediatrics-oncology). Neth R, Gallo RC, Graf T, Mannweiler K, Winkler K (eds), Springer Verlag, 1981, p 107.

    Google Scholar 

  9. Moe P: Central nervous system prophylaxis with intermediate dose methotrexate. This issue.

    Google Scholar 

  10. Haghbin M, Zuelzer WW: A long term study of cerebrospinal leukemia. J Pediat 67:23–28, 1965.

    Article  PubMed  CAS  Google Scholar 

  11. Cook J, Considine B: Low dose radiation therapy for leukemic involvement of the central nervous system. Radiology 104:649–652, 1972.

    PubMed  CAS  Google Scholar 

  12. Coccia P, Sather H, Nesbit M, Weiner J, Donaldson M, Hittle R, Ortega J, Hammond D: Interrelationship of initial WBC, age and sex in predicting prognosis in childhood acute lymphoblastic leukemia (Abstr. #214). Proc Am Hematol, 1976, p 125.

    Google Scholar 

  13. Nesbit ME, Sather HN, Robison LL, Ortega J, Littman PS, D’Angio GJ, Hammond GD: Presymptomatic central nervous system therapy in previously untreated childhood acute lymphoblastic leukemia: comparison of 1800 rad and 2400 rad. A report for Children’s Cancer Study Group. Lancet 1:461–466, 1981.

    Article  PubMed  Google Scholar 

  14. Zuelzer WW: Implications of long term survival in acute stem cell leukemia of childhood treated with comparable cyclic therapy. Blood 26:477–494, 1964.

    Google Scholar 

  15. Ravindranath Y, Inoue S, Considine B, Lusher JM, Zuelzer WW: New leukemia in the course of therapy of acute lymphoblastic leukemia. Am J Hematol 5:211–223, 1978.

    Article  PubMed  CAS  Google Scholar 

  16. Mosijczuk AD, Ruymann FR: Second malignancy in acute lymphocytic leukemia. Review of 33 cases. Am J Dis Child 135:313–316, 1981.

    PubMed  CAS  Google Scholar 

  17. George SL, Aur RJA, Mauer AM, Simme JV: A reappraisal of the results of stop** therapy in childhood leukemia. New Eng J Med 300:269–273, 1979.

    Article  PubMed  CAS  Google Scholar 

  18. Ravindranath Y, Soorya DJ, Schultz GE, Lusher JM: Long term survivors of acute lymphoblastic leukemia - risk of relapse after cessation of therapy. Med Ped Oncol 9:209–218, 1981.

    Article  CAS  Google Scholar 

Download references

Authors
  1. Y. Ravindranath
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Bhambhani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. John K. Kelly
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Schultz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I. Warrier
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B. Considine
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. M. Lusher
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. W. W. Zuelzer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Clinica Pediatrica, Università Cattolica, Roma, Italy

    Renato Mastrangelo MD  & Riccardo Riccardi MD  & 

  2. Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, 20205, USA

    David G. Poplack MD

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Martinus Nijhoff Publishers, Boston

About this chapter

Cite this chapter

Ravindranath, Y. et al. (1983). Central Nervous System Prophylaxis with Intermittent Intrathecal Methotrexate and Fractional Radiation in Childhood Acute Lymphoblastic Leukemia. In: Mastrangelo, R., Poplack, D.G., Riccardi, R. (eds) Central Nervous System Leukemia. Developments in Oncology, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6708-3_5

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-6708-3_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6710-6

  • Online ISBN: 978-94-009-6708-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation