Skip to main content

3 Result(s)

within Chapter Remove this filter John C. Reed Remove this filter Cancer Research Remove this filter

and

  1. No Access

    Chapter

    Roles of Apoptosis-Regulating Bcl-2 Family Genes in AML

    Among the cardinal features of malignancy is abrogation of cell death mechanisms, thus endowing cancer and leukemia cells with a selective survival advantage relative to normal cells. Genetic and epigenetic le...

    John C. Reed in Targeted Therapy of Acute Myeloid Leukemia (2015)

  2. No Access

    Chapter

    Bcl-2 family proteins and the regulation of programmed cell death in leukemia and lymphoma

    Members of the bcl-2 gene family play a central role in regulating the relative sensitivity and resistance of cells to a wide variety of apoptotic stimuli. The first member of this multigene family ,bcl-2, was di...

    John C. Reed, Toshiyuki Miyashita… in Molecular Genetics and Therapy of Leukemia (1996)

  3. No Access

    Chapter

    BCL-2 and Chemoresistance in Cancer

    Programmed cell death is a physiological process that plays a critical role in the regulation of tissue homeostasis by ensuring that the rate at which new cells are produced in the body through cell division i...

    John C. Reed in Alternative Mechanisms of Multidrug Resistance in Cancer (1995)