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Chapter and Conference Paper
Characterisation of Transient Actions Induced by Spectators on Sport Stadia
In a wake of Hillsborough disaster of 1989, all stadia hosting major sport championships in the UK were converted from terraced to all-seated. Driven by spectators’ demands for improving the quality of their e...
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Chapter
Chasing the Long Tail: Growth Through Personalized Telecoms Services
We highlight one of several available transformational paths for traditional telecom operators to respond to challenges of declining revenues in their traditional business. The new opportunities appear in the ...
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Chapter and Conference Paper
Successful Administration of the NO Synthase Inhibitor 546C88 as a Delayed Continuous Infusion in a Baboon Model of Septic Shock
Nitric oxide (NO) as both a vasodilator and under certain circumstances a cyto-toxic molecule is suggested as one of the critical mediators of severe sepsis and septic shock. Whether NO is really a central mol...
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Chapter
Glyceraldehyde and the Pancreatic β-Cell
D-glyceraldehyde is commonly used as a stimulus of insulin release from the pancreatic β-cell1–3. It is generally accepted that the triose can be metabolized in the β-cell via the glycolytic pathway, thus stimula...
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Chapter
Real-time LOTOS and timed observations
This paper presents a new semantic model for real-time LOTOS, based upon a notion of timed observations. The novelty of the model is explained, as is its value. It differs from the usual operational models in ...
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Chapter and Conference Paper
QSO Absorption by Nearby Galaxies
We investigate the obscuration of the distant universe by absorption in foreground spiral galaxies. We have used the most conservative and most radical views highlighted by the recent NATO conference on the op...
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Chapter
Improvement of Barley and Wheat Quality by Genetic Engineering
Although the mature cereal grain consists predominately of starch with only about 10–15% of protein, it is the protein fraction which is largely responsible for quality. In the case of wheat the quality for br...
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Chapter
Monocyte Chemotactic Peptide-1 (Mcp-1) and NAP-1/IL-8 Formation in Baboon Septicemia are Partially TNF Dependent
Cytokines like IL-1 and IL-6 are released in sepsis in a TNF dependent manner. Therefore we asked the question, whether TNF might be responsible for MCP-1 and NAP-1 production in baboon septicemia (2 hours inf...
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Chapter
Morphological Changes in Adult Respiratory Distress Syndrome: Experimental and Clinical Data
Adult respiratory distress syndrome (ARDS) (Fig. 1) is the pulmonary manifestation of a diffuse microcirculatory injury that causes exudation of a protein-rich fluid into the pulmonary interstitium and alveola...
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Chapter
Leukocyte-Endothelial Interactions in Trauma and Sepsis
Polytrauma leads to the release of a multitude of mediators in the humoral and blood cell cascade systems. This mediator release among other reactions, results in interactions between endothelial cells (EC) an...
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Chapter and Conference Paper
The Role of TNF in Gram-Negative Sepsis in Baboon
During sepsis TNF message is expressed and the protein is released both locally and into plasma. Teleologically such cytokine response must be beneficial to the host. However, from a certain threshold level of...
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Chapter and Conference Paper
Trauma and Cytokines
Trauma still constitutes the most frequent cause of death in the first four decades of life and ranks third over all age brackets (Baker et al. 1980, Baue 1990, Chaudry et al. 1990, National Safety Council 198...
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Chapter
Live Escherichia coli Sepsis Models in Baboons
Sepsis and septic shock are usually complex conditions in which the overall picture heavily depends on numerous interrelationships among all organ systems and tissues. In the study of such a complicated proble...
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Chapter
Activation/Adherence Phenomena of Leukocytes and Endothelial Cells in Trauma and Sepsis
Leukocytes, in particular polymorphonuclear neutrophils (PMNs), release important mediators of microvascular injury seen after ischemia/reperfusion, hemorrhage, and sepsis. Adherence of PMNs to the endothelium...
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Chapter
Bacterial Translocation During Traumatic Shock in Baboons
Bacterial translocation secondary to gut damage caused by traumatic shock is a source of posttraumatic sepsis. Enteral bacterial translocation has been implicated as a possible cause of the subsequent developm...
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Chapter and Conference Paper
Precise Localization of a Gene Responsible for Ataxia-Telangiectasia on Chromosome 11q
Ataxia-telangiectasia (A-T) is a recessive disorder of childhood characterized by progressive cerebellar ataxia, occulocutaneous telangiectasias, and a high incidence of cancer and infection. Other distinctive...
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Chapter
Hypovolemic-Traumatic Shock Models in Baboons
Trauma and hemorrhage should closely mimic human polytrauma to create a valid basis for defin itive conclusions on the pathomechanisms and pathophysiology of polytrauma.
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Chapter
The Cytokine Network in Trauma and Sepsis I: TNF and IL-8
During infection and sepsis the genes for many cytokines are expressed and some of the proteins are also released both locally and into plasma. Teleologically, such cytokine response must be beneficial to the ...
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Chapter and Conference Paper
Normal Surface Brightness Dwarf Galaxies in the Fornax Cluster
There are strong selection effects in favour of selecting galaxies of certain surface brightnesses (Disney & Phillipps 1983; Davies 1990), and against finding galaxies of other surface brightnesses. Both low a...
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Chapter and Conference Paper
Bacterial Translocation in a Baboon Model of Hypovolemic-Traumatic Shock
Bacterial translocation secondary to gut damage caused by traumatic shock is a source of posttraumatic sepsis. In several series, only one third of multiorgan failure patients with clinical manifestations of s...
