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Leukocyte-Endothelial Interactions in Trauma and Sepsis

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Host Defense Dysfunction in Trauma, Shock and Sepsis

Abstract

Polytrauma leads to the release of a multitude of mediators in the humoral and blood cell cascade systems. This mediator release among other reactions, results in interactions between endothelial cells (EC) and leukocyte, permeability changes, and organ dysfunction. This short review focuses on these EC-leukocyte interactions and compares the posttraumatic with the sepsis situation.

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References

  1. Schlag G, Redl H (1980) Die Leukostase in der Lunge beim hypovolämisch-traumatischen Schock. Anaesthesist 29:606–612

    PubMed  CAS  Google Scholar 

  2. Redl H, Dinges HP, Schlag G (1987) Quantitative estimation of leukostasis in the posttraumatic lung—canine and human autopsy data. Prog Clin Biol Res 236A:43–53

    PubMed  CAS  Google Scholar 

  3. Pretorius JP, Schlag G, Redl H, Botha WS, Goosen DJ, Bosman H, van Eeden AF (1987) The ‘lung in shock’ as a result of hypovolemic-traumatic shock in baboons. J Trauma 27:1344–1353

    Article  PubMed  CAS  Google Scholar 

  4. Redl H, Schlag G, Dinges HP, Bahrami S, Buurman WA, Schade U, Ceska M (1991) Trauma and sepsis induced activation of granulocytes, monocytes/macrophages and endothelial cells in primates. In: Schlag G, Redl H, Siegel JH, Traber DL (eds) Shock, sepsis, and organ failure— second Wiggers Bernard conference. Springer, Berlin Heidelberg New York, pp 297–313

    Google Scholar 

  5. Mayrovitz H, Wiedeman M, Tuma R (1977) Factors influencing leukocyte adherence in microvessels. Thromb Haemost 38:823–830

    PubMed  CAS  Google Scholar 

  6. House SD, Lipowsky HH (1987) Leukocyte-endothelium adhesion: microhemodynamics in mesentery of the cat. Microvasc Res 34:363–379

    Article  PubMed  CAS  Google Scholar 

  7. Redl H, Schlag G, Hammerschmidt DE (1984) Quantitative assessment of leukostasis in experimental hypovolemic-traumatic shock. Acta Chir Scand 150:113–117

    PubMed  CAS  Google Scholar 

  8. Caddock PR, Hammerschmidt DE, White JG, Dalmasse AP, Jacob HS (1977) Complement (C5a) induced granulocyte aggregation in vitro. A possible mechanism of complement mediated leukostasis and leukopenia. J Clin Invest 60:260–264

    Article  Google Scholar 

  9. Redl H, Hammerschmidt DE, Schlag G (1983) Augmentation by platelets of granulocyte aggregation in response to chemotaxins: studies utilizing an improved cell preparation technique. Blood 61:125–131

    PubMed  CAS  Google Scholar 

  10. Wallis WJ, Hickstein DD, Schwartz BR, June CH, Ochs HD, Beatty PG, Klebanoff SJ, Harlan JM (1986) Monoclonal antibody defined functional epitopes on the adhesion promoting glycoprotein complex (CDwl8) of human neutrophils. Blood 67:1007–1013

    PubMed  CAS  Google Scholar 

  11. Tonnensen MG, Anderson DC, Springer TA, Knedler A, Avdi N, Henson PM (1989) Adherence of neutrophil to cultured human microvascular endothelial cells. Stimulation by chemotatic peptides and lipid mediators and dependence upon the Mac-1, LFA-1, pi50,95 glycoprotein family. J Clin Invest 83:637–646

    Article  Google Scholar 

  12. Bierer BE, Burakoff SJ (1988) T-cell adhesion molecules. FASEB J 2:2584–2590

    PubMed  CAS  Google Scholar 

  13. Arnaout MA, Lanier LL, Faller DV (1988) Relative contribution of the leukocyte molecules Mol, LFA-1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus-specific. J Cell Physiol 137:305–309

    Article  PubMed  CAS  Google Scholar 

  14. Lang H, Jochum M, Fritz H, Redl H (1989) Validity of the elastase assay in intensive care medicine. Prog Clin Biol Res 308:701–706

    PubMed  CAS  Google Scholar 

  15. Redl H, Dinges HP, Buurman WA, van der Linden CJ, Pober JS, Cotran RS, Schlag G (1991) Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovol-emic shock in the baboon. Am J Pathol 139: (in press)

    Google Scholar 

  16. Inthorn D, Szczeponik T, Mühlbayer D, Jochum M, Redl H (1987) Studies of granulocyte function (chemiluminescence response) in postoperative infection. Prog Clin Biol Res 236B:51–58

    PubMed  CAS  Google Scholar 

  17. Redl H, Lamche H, Schlag G (1983) Red cell count dependence of whole blood granulocyte luminescence. Klin Wochenschr 61:163–164

    Article  PubMed  CAS  Google Scholar 

  18. Heflin Ac jr, Brigham KL (1981) Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia. J Clin Invest 68:1253–1260

    Article  PubMed  CAS  Google Scholar 

  19. Flick MR, Peral G, Staub NC (1981) Leukocytes are required for increased lung microvascular permeability after microemboli in sheep. Circ Res 48:344–351

    PubMed  CAS  Google Scholar 

  20. Shasby DM, Fox RB, Haranda RN, Repine JE (1982) Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion. J Appl Physiol 52:1237–1239

    PubMed  CAS  Google Scholar 

  21. Johnson A, Malik AB (1980) Effect of granulocytopenia on extravascular lung water content after microembolization. Am Rev Respir Dis 122:561–566

    PubMed  CAS  Google Scholar 

  22. Heath CA, Lai L, Bizios R, Malik AB (1986) Pulmonary hemodynamic effects of antisheep serum-induced leukopenia. J Leukoc Biol 3:385–392

    Google Scholar 

  23. Winn R, Maunder R, Chi E, Harlan J (1987) Neutrophil depletion does not prevent lung edema after endotoxin infusion in goats. J Appl Physiol 62:116–121

    PubMed  CAS  Google Scholar 

  24. Worthen S, Haslett C, Rees AJ, Gumbay RS, Henson JE, Henson PM (1987). Neutrophil-mediated pulmonary vascular injury. Synergistic effect of trace amounts of lipopolysaccharide and neutrophil stimuli on vascular permeability and neutrophil sequestration in the lung. Am Rev Respir Dis 136:19–28

    Article  PubMed  CAS  Google Scholar 

  25. Vedder NB, Winn RK, Rice CL, Chi EY, Arfors KE, Harlan JM (1988) A monoclonal antibody to the adherence promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits. J Clin Invest 81:939–944

    Article  PubMed  CAS  Google Scholar 

  26. Cooper JA, Neumann PH, Wright SD, Malik AB (1989) Pulmonary vascular sequestration of neutrophils in endotoxemia: role of CD18 leukocyte surface glycoprotein. Am Rev Respir Dis 139:A301

    Article  Google Scholar 

  27. Kaslovsky RA, Horgan MJ, Lum H, McCandless BK, Gilboa N, Wright SD, Malik AB (1990) Pulmonary edema induced by phagocytosing neutrophils. Protective effect of monoclonal antibody against phagocyte CD18 integrin. Circ Res 67:795–802

    PubMed  CAS  Google Scholar 

  28. Hernandez LA, Grisham MB, Twohig B, Arfors KE, Harlan JM, Granzer N (1987) Role of neutrophils in ischemia reperfusion induced microvascular injury. Am J Physiol 253:H699-H703

    PubMed  CAS  Google Scholar 

  29. Schlag G, Redl H (1990) Endothelium as the interface between blood and organ in the evolution of organ failure. In: Schlag G, Redl H, Siegel JH (eds) Shock, sepsis, and organ failure—first Wiggers Bernard conference. Springer, Berlin Heidelberg New York, pp 210–271

    Chapter  Google Scholar 

  30. Pober JS, Cotran RS (1990) The role of endothelial cells in inflammation. Transplantation 50:537–544

    Article  PubMed  CAS  Google Scholar 

  31. Geng JG, Bevilacqua MP, Moore KL, McIntyre TM, Prescott SM, Kim JM, Bliss GA, Zimmerman GA, McEver RP (1990) Rapid neutrophil adhesion to activated endothelium mediated by GMP 140. Nature 343:757–760

    Article  PubMed  CAS  Google Scholar 

  32. Patel KD, Zimmerman GA, Prescott SM, McEver RP, Mclntyre TM (1991) Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils. J Cell Biol 112:749–759

    Article  PubMed  CAS  Google Scholar 

  33. Zimmerman GA, Mclntyre TM, Mehra M, Prescott SM (1990) Endothelial cell associated platelet activating factor: a novel mechanism for signaling intercellular adhesion. J Cell Biol 110:529–540

    Article  PubMed  CAS  Google Scholar 

  34. Bühren V, Maier B, Hower R, Holzmann A, Redl H, Marzi I (1991) PAF-antagonist BN52021 reduces hepatic leukocyte adhesion following intestinal ischemia. Circ Shock 34:134–135

    Google Scholar 

  35. Marzi I, Bühren V, Schüttler A, Trentz O (1991) Recombinant human superoxide dismutase (rh-SOD) to reduce multiple organ failure after trauma—results of a prospective clinical trial. Circ Shock 34:145

    Google Scholar 

  36. Kubes P, Ibbotson G, Russell J, Wallace JL, Granger ND (1990) Role of platelet activating factor in ischemia reperfusion induced leukocyte adherence. Am J Physiol 259:G300-G305

    PubMed  CAS  Google Scholar 

  37. Phillips ML, Nudelman E, Gaeta FCA, Perez M, Singhal AK, Hakomori SI, Paulson JC (1990) ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand sialyl le. Science 250:1130–1132

    Article  PubMed  CAS  Google Scholar 

  38. Walz G, Aruffo A, Kolanus W, Bevilacqua M, Seed B (1990) Recognition by ELAM-1 of the sialyl le determinant on myeloid and tumor cells. Science 250:1132–1135

    Article  PubMed  CAS  Google Scholar 

  39. Flynn WJ, Cryer HM, Garrison RN (1990) Angiotensin II arteriolar mediated constriction is not responsible for persistent intestinal hypoperfusion in rats resuscitated from hemorrhagic shock. Circ Shock 31:57

    Google Scholar 

  40. Leeuwenberg FM, Jeunhomme TMAA, Buurman WA (1989) Induction of an activation antigen on human endothelial cells in vitro. Eur J Immunol 19:715

    Article  PubMed  CAS  Google Scholar 

  41. Luscinskas FW, Cybulsky MI, Kiely JM, Peckins CS, Davis VM, Gomgrone MA jr (1991) Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1. J Immunol 146:1617–1625

    PubMed  CAS  Google Scholar 

  42. Redl H, Schlag G, Paul E, Davies J (1989) Monocyte/macrophage activation with cytokine release after polytrauma and sepsis in the baboon. Circ Shock 27:308

    Google Scholar 

  43. Schlag G, Redl H, Dinges HP, Davies J, Radmore K (1991) Bacterial translocation in a baboon model of hypovolemic-traumatic shock. In: Schlag G, Redl H, Siegel JH, Traber DL (eds) Shock, sepsis, and organ failure—second Wiggers Bernard conference. Springer, Berlin Heidelberg New York, pp 53–83

    Google Scholar 

  44. Pober JS (1988) Cytokine mediated activation of vascular endothelium. Physiology and pathology. Am J Pathol 133:426–433

    PubMed  CAS  Google Scholar 

  45. Ward P (1991) Role of ELAM in inflammation in vivo. In: 2nd international congress on the immune consequences of trauma, shock and sepsis mechanisms and therapeutic approaches, Munich, abstract, p 22

    Google Scholar 

  46. Rothlein R, Dustin ML, Marlin SD, Springer TA (1986) A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 137:1270–1274

    PubMed  CAS  Google Scholar 

  47. Springer TA (1990) Adhesion receptors of the immune system. Nature 346:425–434

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaneschingenstr. 13, 1200, Wien, Vienna, Austria

    H. Redl, G. Schlag & R. Kneidinger

  2. Institute of Pathology, University Graz, Graz, Austria

    H. P. Dinges

  3. Roodeplaat Research Laboratories, Pretoria, South Africa

    J. Davies

Authors
  1. H. Redl
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  2. G. Schlag
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  3. H. P. Dinges
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  4. R. Kneidinger
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  5. J. Davies
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Editor information

Editors and Affiliations

  1. Dept. of Surgery, Ludwig-Maximilians-University Munich, Klinikum Großhadern Marchioninistr. 15, 8000, Munich 70, Germany

    Eugen Faist  & Friedrich W. Schildberg  & 

  2. Dept. of Surgery, McGill University, Room 510.34 687 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada

    Jonathan L. Meakins M.D., D.Sc.

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© 1993 Springer-Verlag, Berlin Heidelberg

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Redl, H., Schlag, G., Dinges, H.P., Kneidinger, R., Davies, J. (1993). Leukocyte-Endothelial Interactions in Trauma and Sepsis. In: Faist, E., Meakins, J.L., Schildberg, F.W. (eds) Host Defense Dysfunction in Trauma, Shock and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77405-8_29

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  • DOI: https://doi.org/10.1007/978-3-642-77405-8_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77407-2

  • Online ISBN: 978-3-642-77405-8

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