12 Result(s)
within
Chapter
Frank Stahl
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Chapter
Aptazymes: Expanding the Specificity of Natural Catalytic Nucleic Acids by Application of In Vitro Selected Oligonucleotides
Aptazymes are synthetic molecules composed of an aptamer domain and a catalytic active nucleic acid unit, which may be a ribozyme or a DNAzyme. In these constructs the aptamer domain serves as a molecular swit...
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Chapter
Spezielle labortechnische Reaktoren: Lab-on-a-Chip
Mikroreaktorsysteme ermöglichen es, auf kleinstem Raum verschiedene Prozessschritte kombiniert ablaufen zu lassen. In diesem Kapitel werden die einzelnen funktionellen Einheiten solcher mikrofluidischen System...
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Chapter and Conference Paper
Experimental investigation of the cold start behavior of different coolant circuits for a waste heat recovery system and their influence on the engine
One of the most promising technologies to increase efficiency and to decrease CO2-emissions for future combustion engines is the utilization of exhaust gas heat through a Rankine cycle. A so called waste heat rec...
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Chapter
Molecular Survival Strategies of Organisms: HSP and Small Molecules for Diagnostics and Drug Development
Nature has developed evolutionary strategies to synthesize the vast number of what are called secondary metabolites or in short natural products. These include molecules that are able to inhibit heat shock pro...
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Chapter
Aptamer-Modified Nanoparticles as Biosensors
Aptamers are short oligonucleotides that are capable of selectively binding to their corresponding target. Therefore, they can be thought of as a nucleic acid-based alternative to antibodies and can substitute...
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Chapter
Isolation of Intact RNA from Sorted S. cerevisiae Cells for Differential Gene Expression Analysis
Individuals within natural populations are highly diverse. They can vary regarding their physiological states and thus contribute differently to the performance of the whole community [1]. Hence, the character...
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Chapter and Conference Paper
A Comparative Study of Suspension Cultivation Systems for the Expansion of Undifferentiated Mouse Embryonic Stem Cells
Embryonic Stem (ES) cells are self- renewing and pluripotent cells that can differentiate into a variety of cell lineages. Implementation in tissue engineering or as model systems for drug discovery makes ES c...
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Chapter and Conference Paper
A New Variant of the Affinity Matrix Method for Identification of High Producing Cells in Mammalian Cell Culture
The screening of high-producing cells is a time consuming procedure. Starting from a single cell after a single cell dilution the procedure takes weeks to complete. The affinity matrix method is a technique fo...
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Chapter
Transcriptome Analysis
Transcriptome analysis technologies are important systems-biology methods for the investigation and optimization of mammalian cell cultures concerning with regard to growth rates and productivity. For the prod...
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Chapter and Conference Paper
A Preliminary Study on Spider Silk as Biomaterial for Peripheral Nerve Regeneration
Biomaterials for Tissue Engineering applications have to be biocompatible and biodegradable, they should enhance cell adhesion and enable sufficient nutrient transport. Moreover, in regard to nerve repair they ha...
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Chapter and Conference Paper
A Study on Bioscaffolds of Polysialic Acid and β-Glucan for Cell Culture and Tissue Engineering Applications
Biopolymers play an important role for cell culture and tissue engineering. The inherent biodegradability and biocompatibility of the biopolymers are important regulation factors for cell and tissue remodellin...
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Chapter
Future Aspects of Bioprocess Monitoring
Nature has the impressive ability to efficiently and precisely control biological processes by applying highly evolved principles and using minimal space and relatively simple building blocks. The challenge...
