20 Result(s)
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Chapter
Normal and Transforming N-Terminal Variants of c-abl
V-abl was first described as the oncogene contained in Abelson murine leukemia virus (A-MuLV), a virus that transforms both lymphocytes and fibroblast lines. The v-abl gene product has a pro...
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Chapter and Conference Paper
Leukotrienes and Prostaglandins Mutually Govern the Antitumor Potential of Macrophages
Macrophages, due to their phagocytosing and secretory function, are effector cells and because of their interaction with lymphocytes, are also looked upon as surveillance cells of the immune system. Eicosanoid...
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Chapter
Use of Micro Array Data via Model-based Classification in the Study and Prediction of Survival from Lung Cancer
We applied a model-based clustering approach to classify tumor tissues on the basis of microarray gene expression. The impact of this classification on cancer biology and clinical outcome was studied. In parti...
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Chapter
Breast Cancer Progression: A “Vicious Cycle” of Pro-Malignancy Activities is Mediated by Inflammatory Cells, Chemokines and Cytokines
Breast cancer progression is a multi-step process, affected by intrinsic, as well as by microenvironmental factors. The inflammatory milieu of breast tumors, comprising of cells, chemokines and cytokines, was ...
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Chapter
Breast Cancer: Diagnosis of Recurrence Using 18 F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography
Breast cancer is the most common cancer and the second leading cause of cancer related death in women. The National Cancer Institute estimates 178,480 women will be diagnosed with breast cancer and 40,640 wome...
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Chapter
The CCL5/CCR5 Axis in Cancer
The multifaceted roles of chemokines and of their receptors in physiological and pathological conditions have motivated researchers to analyze their involvement also in malignant diseases. This chapter focuses...
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Chapter
Radiation Therapy for Adrenocortical Carcinoma
Radiotherapy has been historically considered ineffective in the management of ACC, despite the fact that the modality provides good palliation in unresectable tumors. Further, new research has shown that radi...
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Chapter
Erratum to: The Role of Hematopoietic Growth Factors in Aplastic Anemia: An Evidence-Based Perspective
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Chapter
Mortalin in Invertebrates and The Induction of Apoptosis by Wild-Type p53 Following Defeat of Mortalin-Based Cytoplasmic Sequestration in Cancerous Clam Hemocytes
In this chapter we demonstrate the remarkable sequence homology between mortalin proteins from a broad array of invertebrate taxa, including the few species for which functional analyses have been conducted. W...
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Chapter
The Role of Hematopoietic Growth Factors in Aplastic Anemia: An Evidence-Based Perspective
Evidence-based medicine, which tries to directly base clinical practice and policy decision on supporting evidence, is becoming more and more popular in the establishment of practice guidelines, and is now par...
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Chapter
Evidence-based Anticancer Materia Medica for Lymphoma
The increasing use of herbal remedies during the course of conventional treatment of patients with lymphoma and other hemato-oncological neoplasms is clearly evident. In this chapter we focus on the in vitro, in ...
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Chapter
The Role of Genetic Engineering in Natural Product-Based Anticancer Drug Discovery
Genetic engineering is the process of altering, in a premeditated fashion, the genetic makeup of an organism and has started to play an increasing role in the production and development of clinically significa...
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Chapter
The Versatile World of Inflammatory Chemokines in Cancer
Until recently, inflammatory chemokines were viewed mainly as indispensable “gate keepers” of immunity and inflammation. However, updated research indicates that members of this chemokine sub-family are import...
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Chapter
Dorsal Air Sac Assay
The dorsal air sac assay (DASA) is a simple and convenient in vivo assay to measure angiogenesis and angiogenesis inhibition by substances of interest. In the assay, tumor cells that release angiogenic factors...
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Chapter
HIV Infection and Adipose Tissue Resident Stem Cells: Their Involvement in Pathology and Treatment
The HIV reservoir creates a true challenge for eradicating the virus from infected patients. Current Highly Active Antiretroviral Therapy (HAART) is very effective in controlling active viral replication in th...
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Chapter
At the Crossroads Between Mitochondrial Metabolite Transport and Apoptosis: VDAC1 as an Emerging Cancer Drug Target
Many cancer cells undergo re-programing of metabolism and develop cell survival strategies involving anti-apoptotic defense mechanisms, a hallmark of a great majority of cancer types. The voltage-dependent ani...
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Chapter
Circulating Plasma Tumor DNA
Circulating cell-free DNA (ccfDNA)—first identified in 1947—is “naked” DNA that is free-floating in the blood, and derived from both normal and diseased cells. In the 1970s, scientists observed that patients w...
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Chapter
Circulating Free Tumor DNA (ctDNA): The Real-Time Liquid Biopsy
It is now well established that DNA is shed or secreted into the circulation in both normal and disease states. However, the ability to exploit this knowledge for use in clinical medicine has only recently bee...
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Chapter
Endocrine Disrupting Chemicals and Breast Cancer: The Saga of Bisphenol A
Breast cancer results from time-related complex interactions between internal and external factors. In addition to endogenous estrogens, which play an undisputed role in breast tumorigenesis, exogenous compoun...
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Chapter
A Stroll Down the CerS Lane
The majority of enzymes in the sphingolipid (SL) biosynthetic pathway have been identified over the past couple of decades. Despite significant work, and despite their crucial and central roles in SL synthesis...
