12 Result(s)
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Chapter
Abba J Kastin
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Chapter and Conference Paper
Evolution of neuropeptide concepts illustrated by MIF-1 and MSH
Melanocyte-stimulating hormone (MSH) release-inhibiting factor (MIF)-1 is a tripeptide mainly produced by the hypothalamus. Since its discovery in 1968, MIF-1 has invoked a rich body of literature elucidating ...
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Peptide transport across the blood-brain barrier
No longer considered a static, impenetrable barrier, the dynamic regulatory functions of the blood-brain barrier (BBB) have become increasingly apparent. This is particularly evident for the transport of pepti...
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Chapter
Permeability of the Blood-Brain Barrier to Circulating Free Fatty Acids
The uptake and incorporation by brain of blood-borne free fatty acids (FFA) is a topic with important physiological and diagnostic ramifications. The passage of FFA from blood into brain requires penetration t...
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Chronic Fatigue Syndrome: Possible Integration of Hormonal and Immunological Observations
The editors of this book organized a meeting about an unusual syndrome—chronic fatigue syndrome (CFS). They also applied an unusual approach to the meeting by inviting us to give the “keynote conclusions”. Alt...
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Peptide Transport System-1
Saturable transport across the blood-brain barrier (BBB) has been described for several peptides (Table 1) and regulatory proteins from numerous laboratories1–5. The existence of transporters at the BBB for regul...
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Neuropeptide Modulation of Development and Behavior
Peptides are very simple molecules composed of amino acids linked by bonds resulting from the elimination of water between an amino group in one molecule and a carboxyl group in an adjacent molecule. Neuropept...
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Exchange of Peptides Between the Circulation and the Nervous System: Role of the Blood-Brain Barrier
Peptides can cross the blood-brain barrier (BBB) bidirectionally, that is, from the central nervous system (CNS) to the blood or from the blood to the CNS. Passage occurs by both saturable and nonsaturable mec...
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Relationship of Clinical to Basic Research with Peptides as lllustrated by MSH
Many of the principles that are now influencing the field of brain peptides were established more than a decade ago with melanocyte-stimulating hormone (MSH). A series of studies with MSH demonstrated not only...
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Endogenous Opiate Systems May Modulate Learning and Memory
It is becoming increasingly realized that the endogenous opiate peptides have numerous effects on a wide range of behaviors and physiological conditions. Some of these effects may reflect the multiple physiolo...
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Central Nervous System Effects after Systemic Injection of Opiate Peptides
The discovery of opiate receptors in the brain by Goldstein et al. (1971), Simon et al. (1973), Pert and Snyder (1973), and Terenius (1973) was soon followed by the discovery and sequencing of endogenous opiates ...
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Behavioural Modulation by Systemic Administration of Enkephalins and Endorphins
After the discovery of opiate receptors in the brain by Goldstein et al. (1971), Pert and Snyder (1973), Simon et al. (1973) and Terenius (1973), and the subsequent identification of endogenous opiates by Hughes
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Neuropeptide Influences on the Central Nervous System: A Psychobiological Perspective
The pituitary gland is a small organ (weighing about 60 mg in a human adult male and slightly more in an adult female) which is located at the base of the brain immediately below the hypothalamus. It is divide...
